Product image of Nebivolol Viatris (Nebivolol Hydrochloride) supplied by GNH India

Nebivolol Viatris

Active Ingredient:
Nebivolol Hydrochloride
Origin:
EU

Nebivolol Viatris (Nebivolol Hydrochloride)

Nebivolol, the active ingredient in Nebivolol Viatris, is a beta‑blocker presented as an oral tablet for oral use. It treats hypertension and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Nebivolol Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Sante

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Indications & Clinical Uses

  • Nebivolol is a selective β1‑adrenergic receptor antagonist used in cardiovascular disease management.
  • Hypertension: lowers systemic blood pressure and reduces cardiovascular risk.
  • Heart failure (reduced ejection fraction): improves ventricular function and decreases hospitalization rates.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors, decreasing heart rate and myocardial contractility while also stimulating endothelial nitric‑oxide release, which leads to vasodilation and reduced peripheral vascular resistance, ultimately lowering blood pressure and cardiac workload.

Side Effects

Nebivolol may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Headache
  • Dizziness
  • Fatigue
  • Bradycardia
  • Nausea
  • Nasal congestion

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Acute bronchospasm in susceptible individuals
  • Allergic skin reactions or angioedema
  • Hepatic enzyme elevations
  • Syncope

Precautions & Warnings

  • Before initiating therapy, consider the following safety measures.
  • Monitor blood pressure: ensure adequate control without excessive drop.
  • Assess heart rate: watch for bradycardia, especially in patients with conduction disorders.
  • Use caution in asthma or chronic obstructive pulmonary disease: β‑blockade may exacerbate bronchospasm.
  • Review concomitant beta‑blocker use: avoid additive effects.
  • Adjust in hepatic impairment: dose may need modification.
  • Store at ambient temperature: keep in the original container, protect from moisture.

Avoid Interactions

Nebivolol can interact with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Other beta‑blockers: additive negative chronotropic effects.
  • Calcium‑channel blockers (verapamil, diltiazem): risk of AV‑block and severe bradycardia.
  • Potent CYP2D6 inhibitors (paroxetine, fluoxetine): increase nebivolol plasma levels.
  • Clonidine abrupt withdrawal: may precipitate rebound hypertension.
  • Insulin or oral hypoglycemics: may mask hypoglycemia symptoms.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may attenuate antihypertensive efficacy.
  • Diuretics: heightened risk of orthostatic hypotension.
  • Digoxin: potential for enhanced bradycardia.
  • Other antihypertensives: monitor for additive blood pressure lowering.
  • Antidepressants (serotonergic agents): watch for QT prolongation.

Frequently Asked Questions

Nebivolol Viatris is prescribed for managing high blood pressure (hypertension) and for treating heart failure with reduced ejection fraction, helping to lower cardiovascular risk and improve heart function.

Nebivolol selectively blocks β1‑adrenergic receptors, reducing heart rate and contractility, while also stimulating nitric‑oxide release from the endothelium, which causes blood vessels to relax and lowers peripheral resistance.

The appropriate dose of nebivolol is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any concomitant medications.

Nebivolol’s safety in pregnancy and lactation has not been established; it should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under medical supervision.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Nebivolol is β1‑selective and additionally promotes nitric‑oxide‑mediated vasodilation, which may result in fewer metabolic side effects and better tolerability compared with non‑selective beta‑blockers that lack this vasodilatory property.

Store Nebivolol Viatris at ambient temperature, below 25 °C, in the original packaging and protect it from moisture and direct sunlight to maintain product stability.

Nebivolol Viatris is taken orally, usually once daily, with or without food, as directed by a healthcare professional.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in patients with reactive airway disease, and rare allergic reactions such as angioedema.

Nebivolol is contraindicated in patients with severe sinus bradycardia, second‑ or third‑degree atrioventricular block, cardiogenic shock, and in those with known hypersensitivity to nebivolol or any of its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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