Product image of Nebivolol Viatris Sante (Nebivolol Hydrochloride) supplied by GNH India

Nebivolol Viatris Sante

Active Ingredient:
Nebivolol Hydrochloride
Origin:
EU

Nebivolol Viatris Sante (Nebivolol Hydrochloride)

Nebivolol, the active ingredient in Nebivolol Viatris Sante, is a beta‑blocker presented as an oral dosage form for oral use. It is indicated for the management of hypertension and for treatment of heart failure with reduced ejection fraction in adult patients.

GNH India supplies Nebivolol Viatris Sante as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to strict quality standards and regulatory requirements.

Manufacturer / TM Owner

Viatris Sante

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Indications & Clinical Uses

  • Nebivolol is a selective β1‑adrenergic blocker used in cardiovascular disease management.
  • Hypertension: lowers systolic and diastolic blood pressure, reducing cardiovascular risk.
  • Heart failure (reduced ejection fraction): improves ventricular function and decreases hospitalization rates.
  • Left ventricular dysfunction: supports cardiac remodeling and enhances exercise tolerance.

How It Works

  • Nebivolol selectively antagonizes β1‑adrenergic receptors in cardiac tissue, reducing heart rate and contractility. It also stimulates endothelial nitric‑oxide synthase, leading to nitric‑oxide mediated vasodilation, which further contributes to blood‑pressure reduction and improved myocardial perfusion.

Side Effects

Nebivolol may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Fatigue or tiredness
  • Dizziness or light‑headedness
  • Headache
  • Bradycardia (slow heart rate)
  • Nausea
  • Cough

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm, especially in patients with asthma or COPD
  • Allergic reactions such as rash or angioedema
  • Hepatic dysfunction or elevated liver enzymes
  • Cardiogenic shock in susceptible individuals

Precautions & Warnings

Before prescribing Nebivolol, clinicians should evaluate patient‑specific factors and monitor for potential complications.

  • Monitor blood pressure: ensure adequate control and avoid excessive hypotension.
  • Assess cardiac function: evaluate baseline heart rate and ejection fraction.
  • Use caution in asthma or COPD: β‑blockade may precipitate bronchospasm.
  • Review concomitant beta‑blocker therapy: avoid additive effects.
  • Adjust dose in renal impairment: consider reduced clearance.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Nebivolol can interact with several drug classes, requiring careful assessment.

Major Interactions (Avoid)

  • Other beta‑blockers: additive negative chronotropic effects.
  • Calcium‑channel blockers verapamil or diltiazem: may increase bradycardia risk.
  • Strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine): raise nebivolol plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate hypotensive response.
  • NSAIDs: can attenuate antihypertensive efficacy.
  • Antidiabetic agents: blood‑glucose control may be altered, requiring dose adjustment.

Frequently Asked Questions

Nebivolol Viatris Sante contains nebivolol, a beta‑blocker indicated for the treatment of hypertension and for heart failure with reduced ejection fraction in adult patients. It helps lower blood pressure and improve cardiac function in these conditions.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, reducing heart rate and contractility. In addition, it stimulates endothelial nitric‑oxide production, causing vasodilation. The combined effect decreases peripheral resistance and lowers systemic blood pressure.

The appropriate dose of nebivolol is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any concomitant medications. Dosage adjustments may be needed for renal or hepatic impairment.

Safety data for nebivolol in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Nebivolol Viatris Sante, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nebivolol is a highly selective β1‑blocker that also promotes nitric‑oxide‑mediated vasodilation, which can result in fewer metabolic side effects compared with non‑selective beta‑blockers. Its dual action may offer better tolerability for some patients, though clinical choice depends on individual patient profiles.

Nebivolol Viatris Sante should be stored at room temperature, below 25 °C, in the original packaging. Protect the product from moisture and direct sunlight to maintain its stability and potency.

Nebivolol Viatris Sante is taken orally, usually once daily with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed.

Serious risks include severe bradycardia, marked hypotension, heart block, bronchospasm in patients with reactive airway disease, and rare allergic reactions. Patients should be monitored for these events, especially during treatment initiation or dose changes.

Nebivolol is contraindicated in patients with known hypersensitivity to nebivolol or any excipients, those with severe bradycardia, second‑ or third‑degree atrioventricular block without a pacemaker, and individuals with uncompensated heart failure or cardiogenic shock.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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