Product image of Nebivolol Vida (Nebivolol Hydrochloride) supplied by GNH India

Nebivolol Vida

Active Ingredient:
Nebivolol Hydrochloride
Origin:
EU

Nebivolol Vida (Nebivolol Hydrochloride)

Nebivolol, the active ingredient in Nebivolol Vida, is a beta blocker presented as a tablet for oral use. It treats hypertension and heart failure in adult patients, helping to lower blood pressure and improve cardiac function.

GNH India supplies Nebivolol Vida as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vida – Produtos Farmacêuticos, S.A.

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Indications & Clinical Uses

Nebivolol is a selective β1‑adrenergic antagonist used in cardiovascular disease management.

  • Hypertension: reduces systolic and diastolic blood pressure in patients with primary hypertension.
  • Heart failure: improves left‑ventricular ejection fraction and reduces symptoms in chronic heart failure.
  • Elderly patients with hypertension: provides effective blood‑pressure control with a favorable tolerability profile.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and contractility. In addition, it stimulates endothelial nitric oxide synthase, enhancing nitric oxide release, which causes vasodilation and further lowers peripheral vascular resistance, contributing to its antihypertensive effect.

Side Effects

Nebivolol may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness: especially when standing quickly.
  • Fatigue: general feeling of tiredness.
  • Nasal congestion: mild blockage of nasal passages.
  • Diarrhea: loose stools.
  • Bradycardia: slower than normal heart rate.

Serious or Rare Side Effects

  • Severe bradycardia: heart rate drops to dangerously low levels.
  • Heart block: impairment of electrical conduction.
  • Acute heart failure exacerbation.
  • Bronchospasm: narrowing of airways, especially in asthmatic patients.
  • Hypotension: sudden, marked drop in blood pressure.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Monitor blood pressure: check regularly to ensure therapeutic targets are met.
  • Assess heart rate: watch for excessive bradycardia, especially in patients with conduction disorders.
  • Review cardiac history: avoid in patients with severe sinus bradycardia or second‑degree AV block.
  • Caution in asthma: beta‑blockade may precipitate bronchospasm.
  • Adjust in renal impairment: dose may need modification in severe renal dysfunction.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nebivolol can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Combined use with non‑selective beta‑blockers: risk of profound bradycardia and hypotension.
  • Concomitant strong CYP2D6 inhibitors (e.g., paroxetine, quinidine): may increase nebivolol plasma levels.
  • Co‑administration with calcium‑channel blockers (verapamil, diltiazem): can amplify negative‑inotropic effects.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance antihypertensive effect, requiring blood‑pressure monitoring.
  • Antihyperglycemic agents: beta‑blockade can mask hypoglycemia symptoms.
  • NSAIDs: may reduce antihypertensive efficacy.
  • Antidepressants (tricyclics): may increase risk of cardiac conduction abnormalities.

Frequently Asked Questions

Nebivolol Vida is prescribed for the management of primary hypertension and chronic heart failure in adult patients. By lowering blood pressure and improving cardiac output, it helps reduce the risk of cardiovascular complications associated with these conditions.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, decreasing heart rate and contractility. It also stimulates nitric oxide release from the endothelium, causing vasodilation and reducing peripheral vascular resistance, which together lower systemic blood pressure.

The appropriate dose of Nebivolol Vida is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any comorbidities. Dosage adjustments may be required for renal or hepatic impairment.

The safety of nebivolol during pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nebivolol is a highly selective β1‑blocker with additional nitric‑oxide‑mediated vasodilatory properties, which may offer better tolerability and fewer metabolic side effects compared with non‑selective beta‑blockers. Its unique mechanism can be advantageous in patients who experience fatigue or cold extremities with other agents.

Nebivolol Vida should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Nebivolol Vida is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious risks include severe bradycardia, heart block, acute worsening of heart failure, and marked hypotension. Patients should be monitored for signs of these conditions, especially during treatment initiation or dose adjustments.

Nebivolol Vida is contraindicated in patients with severe sinus bradycardia, second‑degree or higher atrioventricular block, cardiogenic shock, and in those with known hypersensitivity to nebivolol or any excipients in the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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