Product image of Nebivolol Zentiva (Nebivolol) supplied by GNH India

Nebivolol Zentiva

Active Ingredient:
Nebivolol
Origin:
EU

Nebivolol Zentiva (Nebivolol)

Nebivolol, the active ingredient in Nebivolol Zentiva, is a β1‑selective beta‑blocker presented as an oral tablet for oral use. It is used to lower elevated blood pressure and may be prescribed for patients with hypertension or certain forms of heart failure.

GNH India supplies Nebivolol Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Zentiva France

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Indications & Clinical Uses

  • Nebivolol is a β1‑selective beta‑blocker indicated for cardiovascular conditions that involve elevated blood pressure.
  • Hypertension: reduces systolic and diastolic blood pressure, improving overall cardiovascular risk profile.
  • Heart failure: enhances left ventricular function and alleviates symptoms in patients with chronic heart failure.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and myocardial contractility. Concurrently, it stimulates endothelial nitric‑oxide release, causing vasodilation and lowering peripheral vascular resistance, which together contribute to reduced arterial pressure.

Side Effects

Nebivolol may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache
  • Dizziness
  • Fatigue

Serious or Rare Side Effects

  • Severe bradycardia
  • Symptomatic hypotension
  • Bronchospasm

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Monitor blood pressure: ensure adequate control without excessive lowering.
  • Assess cardiac function: evaluate baseline heart rate and rhythm.
  • Use caution in asthma or COPD: β1‑selectivity may still affect bronchial tone.
  • Adjust dose in renal/hepatic impairment: reduced clearance may increase exposure.
  • Avoid abrupt discontinuation: taper to prevent rebound hypertension.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Nebivolol can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Concomitant use with other beta‑blockers
  • Co‑administration with non‑dihydropyridine calcium channel blockers (verapamil, diltiazem)
  • Use with clonidine or abrupt withdrawal of clonidine

Moderate Interactions (Monitor Closely)

  • Combined therapy with insulin or oral hypoglycemics (may mask hypoglycemia)
  • NSAIDs may diminish antihypertensive effect
  • Other antihypertensives (ACE inhibitors, ARBs) may enhance blood‑pressure lowering
  • Certain antidepressants (SSRIs) can increase bradycardia risk

Frequently Asked Questions

Nebivolol Zentiva contains the β1‑selective beta‑blocker nebivolol and is prescribed to lower high blood pressure and to manage chronic heart failure in adults, helping to improve cardiovascular outcomes when used as part of a comprehensive treatment plan.

Nebivolol blocks β1‑adrenergic receptors in the heart, reducing heart rate and contractility. At the same time it stimulates endothelial nitric‑oxide release, causing vasodilation and lowering peripheral resistance, which together contribute to a decrease in arterial pressure.

The specific dose of Nebivolol Zentiva is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any relevant comorbidities. Dosage adjustments are made according to individual therapeutic needs.

Safety data for nebivolol in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nebivolol is distinguished by its high β1‑selectivity and additional nitric‑oxide‑mediated vasodilatory effect, which may result in fewer metabolic side effects compared with non‑selective beta‑blockers. Clinicians often consider it when a patient requires both heart‑rate reduction and improved peripheral vasodilation.

Nebivolol Zentiva tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Do not store in extreme heat or humidity to maintain product stability.

Nebivolol Zentiva is taken orally, usually once daily with or without food, as directed by the prescribing physician. The tablet should be swallowed whole with a glass of water and not chewed or crushed.

Serious risks include severe bradycardia, symptomatic hypotension, and bronchospasm, especially in patients with underlying respiratory disease. Prompt medical attention is required if these events occur, as they can be life‑threatening.

Nebivolol Zentiva is contraindicated in patients with known hypersensitivity to nebivolol, those with severe bradycardia, second‑ or third‑degree AV block without a pacemaker, and individuals with uncompensated heart failure or cardiogenic shock.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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