Product image of Nebivololo E Idroclorotiazide Mylan (Hydrochlorothiazide, Nebivolol) supplied by GNH India

Nebivololo E Idroclorotiazide Mylan

Active Ingredient:
Hydrochlorothiazide, Nebivolol
Origin:
EU

Nebivololo E Idroclorotiazide Mylan (Hydrochlorothiazide, Nebivolol)

Nebivolol/Hydrochlorothiazide, the active ingredients in Nebivololo E Idroclorotiazide Mylan, are a beta‑blocker/thiazide diuretic combination presented as a tablet for oral use. It treats hypertension in adult patients.

GNH India supplies Nebivololo E Idroclorotiazide Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mylan S.P.A.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nebivolol/Hydrochlorothiazide is used to manage hypertension, a condition characterized by elevated arterial pressure.

  • Essential hypertension: lowers systolic and diastolic blood pressure and reduces cardiovascular risk.
  • Secondary hypertension: assists in controlling blood pressure when the underlying cause is identified.
  • Isolated systolic hypertension: helps achieve target systolic pressures in older adults.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors, reducing heart rate and contractility while enhancing nitric‑oxide release for vasodilation. Hydrochlorothiazide inhibits Na⁺/Cl⁻ reabsorption in the distal convoluted tubule, promoting diuresis, decreasing plasma volume, and contributing to blood‑pressure reduction.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness.
  • Headache.
  • Fatigue or mild weakness.
  • Increased urination.
  • Electrolyte disturbances such as low potassium.

Serious or Rare Side Effects

  • Severe hypotension.
  • Significant electrolyte imbalances (e.g., hyponatremia, hypokalemia).
  • Acute kidney injury.
  • Bradycardia.
  • Allergic reactions including rash or angioedema.

Precautions & Warnings

Patients should be monitored for blood‑pressure response and renal function, and electrolyte levels should be checked regularly.

  • Blood‑pressure monitoring: ensure adequate control without excessive lowering.
  • Renal function assessment: adjust use in impaired kidney function.
  • Electrolyte surveillance: watch for hypokalemia or hyponatremia.
  • Diabetes caution: monitor blood glucose as diuretics may affect glucose control.
  • Discontinuation: avoid abrupt cessation to prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nebivolol/Hydrochlorothiazide may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Other antihypertensives (e.g., ACE inhibitors, ARBs) may cause additive hypotension.
  • Potassium‑sparing diuretics: risk of hyper‑kalemia.
  • Lithium: increased lithium levels and toxicity.
  • Strong CYP2D6 inhibitors (e.g., paroxetine): raise nebivolol concentrations.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce diuretic efficacy and affect renal function.
  • Antidiabetic agents: diuretic‑induced changes in glucose may require dose adjustment.
  • Calcium‑channel blockers: may enhance blood‑pressure lowering effect.

Frequently Asked Questions

Nebivololo E Idroclorotiazide combines nebivolol and hydrochlorothiazide to treat hypertension. The beta‑blocker component reduces heart rate and vascular resistance, while the thiazide diuretic promotes fluid loss, together helping to lower elevated blood pressure in adult patients.

Nebivolol selectively blocks β1‑adrenergic receptors, decreasing cardiac output and heart rate. It also stimulates nitric‑oxide release, causing vasodilation. This dual action contributes to reduced arterial pressure when used with hydrochlorothiazide.

The appropriate dose is determined by the prescribing clinician based on the patient’s blood‑pressure profile, renal function, and concomitant medications. Dosage adjustments are individualized and should follow the prescriber’s instructions.

Safety in pregnancy and lactation has not been fully established. The product should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nebivololo E Idroclorotiazide offers the combined benefits of a cardio‑selective β1‑blocker and a thiazide diuretic in a single tablet, potentially simplifying regimens compared with separate agents. It may be preferred when both heart‑rate control and diuretic action are desired, whereas other classes such as ACE inhibitors or ARBs work via different mechanisms.

Store the tablets at room temperature, below 25 °C, in the original packaging. Protect them from moisture, excessive heat, and direct sunlight to maintain product stability.

The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious risks include severe hypotension, significant electrolyte disturbances (especially low potassium), acute kidney injury, bradycardia, and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience fainting, rapid heartbeat, severe dizziness, or signs of an allergic response.

Patients with known hypersensitivity to nebivolol, hydrochlorothiazide, or any component of the formulation should avoid this product. It is also contraindicated in individuals with severe bradycardia, uncontrolled heart failure, or significant electrolyte imbalances unless corrected under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.