Product image of Nedal (Nebivolol Hydrochloride) supplied by GNH India

Nedal

Active Ingredient:
Nebivolol Hydrochloride
Origin:
EU

Nedal (Nebivolol Hydrochloride)

Nebivolol, the active ingredient in Nedal, is a beta blocker presented as a tablet for oral use. It selectively blocks β1‑adrenergic receptors and also enhances nitric‑oxide release, helping to lower blood pressure and improve cardiac function in adults with hypertension or heart failure. It is indicated for the management of high blood pressure and for chronic heart failure, offering a once‑daily dosing option that supports patient adherence.

GNH India supplies Nedal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Nebivolol is a selective β1‑adrenergic blocker used in cardiovascular disease management.

  • Hypertension: lowers systolic and diastolic blood pressure, improving overall control in adults with primary hypertension.
  • Heart failure: enhances left ventricular ejection fraction and reduces symptoms in chronic heart failure patients.
  • Diabetes‑associated hypertension: provides effective blood pressure reduction with a favorable metabolic profile for patients with type 2 diabetes.
  • Elderly patients with hypertension: offers once‑daily dosing that supports adherence and reduces cardiovascular risk in older adults.

How It Works

  • Nebivolol acts as a highly selective β1‑adrenergic receptor antagonist, diminishing sympathetic stimulation of the heart and peripheral vessels. Concurrently, it stimulates endothelial nitric‑oxide synthase, increasing nitric‑oxide production that causes vasodilation. The combined β1‑blockade and nitric‑oxide‑mediated vasodilation lower cardiac workload, reduce systemic vascular resistance, and consequently decrease arterial pressure while improving cardiac efficiency.

Side Effects

Nebivolol may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache
  • Dizziness
  • Fatigue
  • Nasal congestion
  • Bradycardia
  • Nausea

Serious or Rare Side Effects

  • Severe bradycardia
  • Heart block
  • Acute heart failure exacerbation
  • Bronchospasm in asthmatic patients
  • Elevated liver enzymes
  • Allergic skin reactions

Precautions & Warnings

When prescribing Nebivolol, clinicians should consider several safety measures.

  • Blood pressure monitoring: check regularly during initiation and dose adjustments.
  • Heart rate monitoring: observe for excessive bradycardia.
  • Asthma or COPD: use with caution due to potential bronchospasm.
  • Renal impairment: dose adjustment may be required.
  • Drug interactions: review concomitant medications for beta‑blocker or CYP2D6 inhibitors.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Nebivolol can interact with various medicines; careful review is essential.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: additive bradycardia and hypotension.
  • Calcium channel blockers (verapamil, diltiazem): risk of severe bradycardia.
  • Clonidine abrupt withdrawal: may cause rebound hypertension.
  • CYP2D6 inhibitors (paroxetine, fluoxetine): increase nebivolol plasma levels.
  • Insulin or oral hypoglycemics: may mask hypoglycemia symptoms.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance antihypertensive effect.
  • ACE inhibitors or ARBs: additive blood pressure lowering.
  • Tricyclic antidepressants: may increase risk of cardiac conduction effects.
  • NSAIDs: may reduce antihypertensive efficacy.
  • Antiplatelet agents: monitor for bleeding if combined with other antihypertensives.

Frequently Asked Questions

Nedal contains nebivolol, a beta‑blocker indicated for the treatment of primary hypertension and chronic heart failure in adult patients. It helps lower blood pressure and improve cardiac function, reducing the risk of cardiovascular complications associated with these conditions.

Nebivolol selectively blocks β1‑adrenergic receptors, reducing heart rate and contractility, while also stimulating endothelial nitric‑oxide synthase. The increased nitric‑oxide leads to vasodilation, together lowering systemic vascular resistance and arterial pressure, which improves overall cardiovascular performance.

The dosage of Nedal is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any comorbidities. Physicians adjust the dose to achieve optimal blood pressure control or heart‑failure management, following local prescribing guidelines.

Safety data for nebivolol in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers should discuss risks and alternatives with pregnant or nursing patients before initiating therapy.

To order Nedal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nedal (nebivolol) offers high β1‑selectivity and additional nitric‑oxide‑mediated vasodilation, which may provide better blood‑pressure control and a more favorable metabolic profile compared with non‑selective beta‑blockers. Its once‑daily dosing can improve adherence, but choice of therapy should be individualized based on patient characteristics and clinical guidelines.

Nedal should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct light, and ensure they are out of reach of children.

Nedal is taken orally, usually once daily, with or without food, as directed by a healthcare professional. Patients should swallow the tablet whole with a glass of water and follow the prescriber’s instructions regarding timing and any dose adjustments.

Serious risks include severe bradycardia, heart block, acute worsening of heart failure, bronchospasm in patients with asthma or COPD, and rare liver enzyme elevations. Patients should be monitored for these events, especially during treatment initiation or when combined with interacting medications.

Nedal is contraindicated in patients with known hypersensitivity to nebivolol or any excipients, those with severe bradycardia, second‑ or third‑degree atrioventricular block without a pacemaker, and individuals with uncompensated heart failure. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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