Nefopam Hydrochloride Teva Uk (Nefopam Hydrochloride)

Nefopam Hydrochloride is used to manage pain conditions that involve central sensitisation pathways.

• Moderate acute pain: provides analgesia for short‑term severe pain episodes.
• Post‑operative pain: helps control pain after surgical procedures.
• Musculoskeletal pain: relieves pain associated with strains, sprains and other musculoskeletal injuries.

• Nefopam Hydrochloride inhibits the reuptake of norepinephrine, serotonin and dopamine while also blocking voltage‑sensitive sodium channels. This combined action reduces neuronal excitability in the central nervous system, producing analgesia without engaging opioid receptors.

Nefopam Hydrochloride may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

• Dry mouth: reduced salivary flow.
• Sweating: increased perspiration.
• Nausea: mild gastrointestinal upset.
• Dizziness: transient light‑headedness.
• Blurred vision: temporary visual disturbances.
• Constipation: reduced bowel motility.

Serious or Rare Side Effects

• Tachycardia: rapid heart rate requiring monitoring.
• Seizures: rare occurrence, especially at high doses.
• Severe hypotension: significant drop in blood pressure.
• Allergic reactions: rash, urticaria or angioedema.
• Hepatic dysfunction: elevated liver enzymes.
• Psychotic symptoms: hallucinations or agitation.

Before prescribing Nefopam Hydrochloride, clinicians should consider several safety aspects.

• Cardiovascular disease: monitor heart rate and blood pressure.
• Seizure disorders: avoid in patients with a history of epilepsy.
• Liver impairment: use with caution and assess hepatic function.
• Renal impairment: adjust use if significant kidney dysfunction is present.
• Concomitant MAO inhibitors: avoid due to risk of hypertensive crisis.
• Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Nefopam Hydrochloride can interact with other medicines, altering its safety profile.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): risk of severe hypertension.
• Tricyclic antidepressants: increased serotonergic activity.
• Antihypertensive agents: additive blood pressure lowering.

Moderate Interactions (Monitor Closely)

• Other serotonergic drugs (SSRIs, SNRIs): monitor for serotonin syndrome.
• Anticholinergic medications: may exacerbate dry mouth.
• CYP450 substrates: potential alteration of plasma levels, requiring dose adjustment.