Product image of Nefopam (Nefopam Hydrochloride) supplied by GNH India

Nefopam

Active Ingredient:
Nefopam Hydrochloride
Origin:
EU

Nefopam (Nefopam Hydrochloride)

Nefopam, the active ingredient in Nefopam, is a non‑opioid analgesic presented as an oral tablet for systemic use. It is indicated for the management of moderate acute pain, post‑operative pain and musculoskeletal pain, providing relief in adult patients when opioid therapy is not required.

GNH India supplies Nefopam as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets. The product is sourced from EU manufacturers and meets European pharmacopoeial standards.

Manufacturer / TM Owner

Crescent Pharma Limited

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Indications & Clinical Uses

Nefopam is used to manage pain conditions that involve central sensitization and acute nociceptive pathways.

  • Moderate acute pain: provides analgesia for short‑term severe pain episodes.
  • Post‑operative pain: reduces pain intensity after surgical procedures.
  • Musculoskeletal pain: alleviates pain associated with strains, sprains and inflammatory conditions.

How It Works

  • Nefopam inhibits the reuptake of serotonin, norepinephrine and dopamine, increasing their synaptic concentrations, and blocks voltage‑gated sodium channels in central neurons. It also interferes with calcium influx, contributing to decreased neuronal excitability. These combined effects produce a balanced analgesic profile that is effective for various acute pain states while avoiding opioid‑related side effects.

Side Effects

Nefopam may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild to moderate feeling of sickness, often transient.
  • Dry mouth: reduced salivation leading to a sticky oral sensation.
  • Sweating: increased perspiration, especially in warm environments.
  • Dizziness: sensation of light‑headedness that may affect balance.
  • Blurred vision: temporary visual disturbance that usually resolves.
  • Constipation: reduced bowel movements causing abdominal discomfort.

Serious or Rare Side Effects

  • Seizures: risk of convulsive episodes, particularly at high doses.
  • Tachycardia: rapid heart rate that may be symptomatic.
  • Hypotension: low blood pressure leading to dizziness or fainting.
  • Allergic reactions: rash, urticaria, or angioedema indicating hypersensitivity.
  • Hepatotoxicity: liver enzyme elevations that may signal liver stress.
  • Blood dyscrasias: rare abnormalities in blood cell counts.

Precautions & Warnings

When prescribing Nefopam, clinicians should consider several precautionary measures to ensure safe use.

  • Assess renal function: adjust use in patients with severe renal impairment.
  • Monitor cardiovascular status: avoid in uncontrolled hypertension or arrhythmias.
  • Evaluate psychiatric history: caution in patients with seizure disorders or severe anxiety.
  • Review concomitant serotonergic agents: risk of serotonin syndrome.
  • Avoid use in children: safety and efficacy not established.
  • Store at ambient temperature: keep tablets in original container, protect from moisture and direct sunlight.

Avoid Interactions

Nefopam can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • MAO inhibitors: risk of severe hypertension and serotonin syndrome.
  • SSRIs or SNRIs: increased serotonin levels may precipitate serotonin syndrome.
  • Tricyclic antidepressants: additive anticholinergic effects and seizure risk.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may blunt blood pressure‑lowering effect.
  • Anticonvulsants: possible reduction in seizure threshold.
  • Anticholinergic drugs: enhanced dry mouth and constipation.
  • CYP450 substrates: Nefopam may affect metabolism of drugs processed by CYP2D6.

Frequently Asked Questions

Nefopam is prescribed to relieve moderate acute pain, post‑operative pain, and musculoskeletal pain. It is a non‑opioid option that works centrally to reduce pain perception in adult patients when opioid therapy is not indicated.

Nefopam blocks the reuptake of serotonin, norepinephrine and dopamine while also inhibiting voltage‑gated sodium channels and calcium influx in central neurons. This multimodal action dampens central sensitization and modulates pain pathways, producing analgesia without engaging opioid receptors.

The appropriate dose of Nefopam is determined by the prescribing healthcare professional based on the individual’s clinical condition, severity of pain, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Nefopam during pregnancy and lactation are limited, and the pregnancy category is listed as unknown. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.

To order Nefopam, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with opioid analgesics, Nefopam offers pain relief without opioid‑related respiratory depression or dependence risk. Unlike other non‑opioid agents such as tramadol, Nefopam does not act on opioid receptors but modulates monoamine pathways, which may result in a different side‑effect profile, especially regarding nausea and cardiovascular effects.

Nefopam tablets should be stored at ambient temperature, below 25 °C, in their original packaging to protect them from moisture and direct sunlight. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

Nefopam is administered orally as a tablet. It should be swallowed whole with a glass of water, preferably with food or a light snack to reduce gastrointestinal discomfort. The exact timing and frequency are determined by the prescribing clinician.

Serious risks include seizures, especially at high doses or in patients with a seizure history, and serotonin syndrome when combined with other serotonergic drugs. Cardiovascular concerns such as tachycardia or hypotension may also occur, so patients should report any rapid heartbeat, faintness, or unusual neurological symptoms promptly.

Nefopam should be avoided in children, patients with severe renal impairment, those currently taking monoamine oxidase inhibitors, and individuals with a known hypersensitivity to the drug. Caution is also advised for patients with uncontrolled hypertension, cardiac arrhythmias, or a history of seizures.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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