Product image of Nefopam Teva (Nefopam Hydrochloride) supplied by GNH India

Nefopam Teva

Active Ingredient:
Nefopam Hydrochloride
Origin:
EU

Nefopam Teva (Nefopam Hydrochloride)

Nefopam Hydrochloride, the active ingredient in Nefopam Teva, is a non‑opioid analgesic presented as a parenteral solution for intramuscular and intravenous use. It is employed to manage moderate to severe acute pain, including post‑operative pain, in adult patients by acting centrally on pain pathways.

GNH India supplies Nefopam Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory support for global distribution.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Nefopam Teva is a centrally acting non‑opioid analgesic used for acute pain management.

  • Moderate to severe acute pain: provides effective analgesia for sudden, intense pain episodes.
  • Post‑operative pain: reduces discomfort following surgical procedures.
  • Acute musculoskeletal pain: helps control pain after injuries or strain.

How It Works

  • Nefopam Hydrochloride acts centrally by inhibiting the reuptake of serotonin, norepinephrine, and dopamine, while also blocking voltage‑sensitive sodium channels and modulating calcium influx. These combined actions diminish neuronal excitability and interrupt pain signal transmission within the central nervous system, resulting in analgesia without opioid receptor involvement.

Side Effects

Nefopam Teva may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Dry mouth: reduced salivation.
  • Sweating: increased perspiration.
  • Tachycardia: elevated heart rate.
  • Blurred vision: temporary visual disturbances.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Seizures: risk of convulsive episodes, especially at high doses.
  • Severe hypotension: marked drop in blood pressure.
  • Allergic reactions: rash, itching, or anaphylaxis.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Agranulocytosis: rare blood cell deficiency.
  • Hepatic dysfunction: abnormal liver enzyme elevations.

Precautions & Warnings

Before using Nefopam Teva, consider the following safety measures.

  • Renal impairment: monitor kidney function and adjust therapy if needed.
  • Cardiovascular disease: observe heart rate and blood pressure closely.
  • History of seizures: use with caution due to seizure risk.
  • Pregnancy: safety not established; weigh benefits against potential risks.
  • Concomitant MAO inhibitors: avoid because of possible hypertensive crisis.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nefopam Teva can interact with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • MAO inhibitors: may precipitate hypertensive crisis.
  • Serotonergic agents (e.g., SSRIs, SNRIs): increased risk of serotonin syndrome.
  • Tricyclic antidepressants: can amplify cardiovascular effects.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive hypotensive effect.
  • Anticholinergic drugs: may worsen dry mouth.
  • CYP450 inhibitors: potential increase in nefopam plasma concentrations.

Frequently Asked Questions

Nefopam Teva is a prescription medication containing nefopam hydrochloride, a non‑opioid analgesic indicated for the relief of moderate to severe acute pain, including pain that follows surgical procedures. It is administered by injection to provide rapid pain control in adult patients.

Nefopam hydrochloride works centrally by blocking the reuptake of serotonin, norepinephrine, and dopamine, and by inhibiting voltage‑sensitive sodium channels while modulating calcium influx. These actions reduce neuronal excitability and interrupt the transmission of pain signals within the central nervous system, producing analgesia without engaging opioid receptors.

The dosage of Nefopam Teva is determined by the prescribing healthcare professional based on the severity of pain, the patient’s clinical condition, and the route of administration. The prescriber will set the appropriate dose and frequency according to current medical guidelines.

Safety data for nefopam hydrochloride in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers should discuss individual circumstances with the patient before prescribing.

To order Nefopam Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

Nefopam Teva offers analgesia without opioid‑related side effects such as respiratory depression or dependence. Compared with traditional NSAIDs, it does not inhibit cyclo‑oxygenase enzymes, reducing the risk of gastrointestinal ulceration. Its central mechanism provides an alternative for patients who cannot tolerate opioids or NSAIDs.

Nefopam Teva should be stored below 25 °C (77 °F) in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain its stability and potency.

Nefopam Teva is supplied as a sterile injectable solution and can be given either intramuscularly or intravenously by a qualified healthcare professional. The route, infusion rate, and volume are determined by the prescriber according to the clinical situation.

The most serious adverse reactions include seizures, severe hypotension, allergic anaphylactic responses, and cardiac arrhythmias. Patients with a history of seizures, uncontrolled hypertension, or known hypersensitivity to nefopam should be monitored closely or may need to avoid the medication.

Nefopam Teva is contraindicated in patients with known hypersensitivity to nefopam hydrochloride or any of its excipients. It should also be avoided in individuals taking monoamine oxidase inhibitors, those with uncontrolled epilepsy, and patients for whom the risk of cardiovascular side effects outweighs the analgesic benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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