Product image of Nefrosol (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra) supplied by GNH India

Nefrosol

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra
Origin:
EU

Nefrosol (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra)

Sodium hydrogen carbonate, the active ingredient in Nefrosol, is a IV electrolyte solution presented as a solution for injection for intravenous use. It provides electrolyte replacement and helps maintain fluid balance in patients requiring intravenous therapy.

GNH India supplies Nefrosol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

B.Braun Avitum Ag

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nefrosol is employed in clinical situations that require intravenous electrolyte and fluid management.

  • Diluent for intravenous medications: Provides a compatible carrier solution for reconstituting and diluting injectable drugs.
  • Electrolyte replacement therapy: Restores sodium, chloride, calcium, and magnesium levels in patients with deficits.
  • Fluid resuscitation in dehydration: Supplies necessary volume and electrolytes to support circulatory volume.
  • Correction of electrolyte imbalances: Adjusts specific ion concentrations such as hyponatremia, hypocalcemia, or hypomagnesemia.

How It Works

  • Nefrosol delivers sodium hydrogen carbonate, magnesium chloride, sodium chloride, and calcium chloride directly into the bloodstream, where the ions dissociate and replenish extracellular fluid osmolarity, buffer capacity, and specific electrolyte concentrations, thereby supporting normal cellular function and acid‑base balance.

Side Effects

Nefrosol may be associated with adverse reactions following intravenous administration.

Common Side Effects

  • Injection site pain: Mild discomfort at the infusion site.
  • Mild hypernatremia: Slight increase in serum sodium.
  • Mild hyperchloremia: Slight elevation of chloride levels.
  • Transient metabolic alkalosis: Temporary rise in blood pH.
  • Mild hypercalcemia: Small increase in calcium concentration.
  • Mild hypermagnesemia: Small increase in magnesium concentration.

Serious or Rare Side Effects

  • Severe hypernatremia: Marked elevation of serum sodium requiring urgent intervention.
  • Severe metabolic alkalosis: Significant pH shift that may affect cardiovascular function.
  • Anaphylactic reaction: Acute hypersensitivity requiring emergency treatment.
  • Circulatory overload: Fluid accumulation leading to pulmonary edema.

Precautions & Warnings

When using Nefrosol, clinicians should observe several safety measures.

  • Assess electrolyte status before administration: Check serum sodium, chloride, calcium, and magnesium levels.
  • Monitor fluid balance: Track input/output and watch for signs of overload.
  • Adjust infusion rate in renal impairment: Reduce volume to avoid accumulation.
  • Avoid concurrent hypertonic solutions: Prevent excessive electrolyte load.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Nefrosol can interact with other intravenous therapies and medications.

Major Interactions (Avoid)

  • Concurrent use of hypertonic saline solutions: Increases risk of severe hypernatremia.
  • Co‑administration with calcium‑containing medications: May cause calcium overload.
  • Use with potassium‑sparing diuretics: Can exacerbate electrolyte imbalance.

Moderate Interactions (Monitor Closely)

  • Concurrent IV antibiotics with nephrotoxic potential: Requires renal function monitoring.
  • Simultaneous infusion of blood products: Watch for electrolyte shifts.

Frequently Asked Questions

Nefrosol is an intravenous electrolyte solution used as a diluent for injectable medications and for the replacement of sodium, chloride, calcium, and magnesium in patients who need fluid and electrolyte balance, such as those undergoing surgery, trauma care, or severe dehydration.

Sodium hydrogen carbonate dissociates after intravenous infusion, providing bicarbonate ions that act as a buffer to help regulate blood pH, while the accompanying sodium, chloride, calcium, and magnesium ions replenish extracellular electrolyte pools, supporting normal cellular and cardiovascular function.

The dose of Nefrosol is determined by the prescribing clinician based on the patient’s electrolyte status, fluid requirements, and clinical condition. Dosage calculations consider serum ion concentrations, body weight, and the intended therapeutic goal.

Safety data for Nefrosol in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order Nefrosol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs), and import documentation.

Nefrosol contains a combination of sodium hydrogen carbonate, magnesium chloride, sodium chloride, and calcium chloride, offering a broader electrolyte profile than standard solutions such as normal saline or Ringer's lactate, which lack bicarbonate and magnesium. This makes Nefrosol suitable for patients needing simultaneous correction of multiple electrolyte deficits.

Nefrosol should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Before use, inspect the container for any particulate matter or discoloration and allow the solution to reach room temperature if required for infusion.

Nefrosol is administered intravenously as a sterile solution for injection. It can be infused directly or used to dilute other injectable drugs, following the prescribing clinician’s instructions regarding infusion rate, volume, and compatibility with other IV fluids.

Serious risks include severe hypernatremia, marked metabolic alkalosis, anaphylactic reactions, and circulatory overload leading to pulmonary edema. Prompt monitoring of serum electrolytes, acid‑base status, and fluid balance is essential to detect and manage these complications early.

Nefrosol should be avoided in patients with known hypersensitivity to any of its components, those with existing severe hypernatremia, hypercalcemia, or hypermagnesemia, and individuals with uncontrolled fluid overload unless the benefits clearly outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT