Neiratax (Thiamine Hydrochloride, Cyanocobalamin, Pyridoxine Hydrochloride, Lidocaine Hydrochloride)

Neiratax is indicated for conditions related to vitamin B deficiencies and for procedural pain management.

• Vitamin B1 deficiency: restores thiamine levels to support carbohydrate metabolism.
• Vitamin B12 deficiency: supplies cobalamin needed for DNA synthesis and red blood cell formation.
• Vitamin B6 deficiency: provides pyridoxine for amino‑acid metabolism and neurotransmitter synthesis.
• Local anesthesia: delivers lidocaine to block nerve transmission and reduce pain during minor procedures.

• Thiamine Hydrochloride acts as a cofactor for enzymes in carbohydrate metabolism, facilitating energy production. Cyanocobalamin (Vitamin B12) serves as a cofactor for methionine synthase, supporting DNA synthesis and red blood cell formation. Pyridoxine Hydrochloride (Vitamin B6) functions as a cofactor for transamination reactions in amino‑acid metabolism. Lidocaine Hydrochloride blocks voltage‑gated sodium channels in neuronal membranes, preventing depolarization and providing local anesthetic effect.

Neiratax may cause a range of adverse reactions following intramuscular administration.

Common Side Effects

• Injection site pain or tenderness.
• Mild erythema or swelling at the injection site.
• Transient numbness or tingling in the area.
• Headache.
• Nausea.
• Dizziness.

Serious or Rare Side Effects

• Allergic reaction including rash, itching or swelling.
• Anaphylaxis, a severe, potentially life‑threatening reaction.
• Severe hypotension or cardiovascular collapse.
• Cardiac arrhythmias.
• Seizures.
• Persistent or prolonged numbness beyond the expected duration.

Before using Neiratax, consider the following safety measures.

• Assess deficiency status: confirm vitamin B1, B12 or B6 deficiency before administration.
• Monitor for allergic reactions: observe patients for signs of hypersensitivity during and after injection.
• Cardiac caution: use with care in patients with known conduction disorders or severe cardiac disease.
• Avoid in lidocaine hypersensitivity: do not administer to individuals with documented lidocaine allergy.
• Adjust in organ impairment: consider renal or hepatic dysfunction when determining dose.
• Store at ambient temperature: keep in original packaging, protect from moisture and light.

Neiratax can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Concurrent use of other local anesthetics: may increase risk of systemic toxicity.
• High‑dose beta‑blockers: can potentiate lidocaine‑induced bradycardia.
• MAO inhibitors: may enhance hypotensive effects of lidocaine.

Moderate Interactions (Monitor Closely)

• Anticoagulants (e.g., warfarin): increased bleeding risk at injection site.
• CYP450 substrates (e.g., certain antiepileptics): vitamins may alter metabolism of some drugs.
• Diuretics: may affect electrolyte balance, influencing lidocaine activity.