Neiraxin (Thiamine Hydrochloride, Cyanocobalamin, Pyridoxine Hydrochloride, Lidocaine Hydrochloride)

Neiraxin is a combination injectable that addresses vitamin B deficiencies and provides local anesthetic effect.

• Vitamin B1 deficiency: supports carbohydrate metabolism and neurological function.
• Vitamin B12 deficiency: aids red blood cell formation and nerve health.
• Vitamin B6 deficiency: contributes to amino‑acid metabolism and neurotransmitter synthesis.
• Minor surgical or diagnostic procedures: offers temporary local anesthesia to reduce procedural discomfort.

• The thiamine, cyanocobalamin and pyridoxine components act as essential co‑enzymes in cellular metabolism, facilitating carbohydrate, fatty‑acid and amino‑acid pathways that sustain neuronal and hematologic function. Lidocaine hydrochloride blocks voltage‑gated sodium channels in peripheral nerves, preventing depolarization and producing reversible loss of sensation at the injection site.

Adverse reactions may occur following intramuscular administration of Neiraxin.

Common Side Effects

• Mild pain or irritation at the injection site.
• Transient redness or swelling.
• Light‑headedness or dizziness.
• Nausea or mild gastrointestinal upset.
• Headache.
• Temporary tingling or numbness beyond the intended area.

Serious or Rare Side Effects

• Allergic reaction such as rash, itching, swelling, or anaphylaxis.
• Severe hypotension or cardiovascular collapse.
• Persistent neuropathic pain.
• Hemolytic anemia.
• Seizures.
• Cardiac arrhythmias.

Neiraxin should be administered with consideration of patient history and clinical context.

• Allergy assessment: verify no known hypersensitivity to B‑vitamins or lidocaine.
• Cardiac monitoring: observe patients with pre‑existing heart conduction disorders.
• Renal or hepatic impairment: adjust use based on organ function.
• Pregnancy and lactation: evaluate risk‑benefit ratio before prescribing.
• Pediatric use: limit to situations where benefits outweigh potential risks.
• Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Neiraxin may interact with other agents that affect vitamin metabolism or sodium channel function.

Major Interactions (Avoid)

• Concurrent use of other local anesthetics: risk of cumulative toxicity.
• High‑dose metformin: may increase risk of lactic acidosis when combined with thiamine deficiency correction.

Moderate Interactions (Monitor Closely)

• Anticoagulants: monitor for increased bleeding at injection site.
• Anticonvulsants: may alter pyridoxine levels.
• Alcohol: can potentiate lidocaine’s CNS effects.
• Diuretics: may affect renal clearance of vitamins.
• Proton‑pump inhibitors: may reduce absorption of oral B‑vitamins, though less relevant for IM route.