Product image of Neisvac-C (N. Meningitidis Group C (Strain C11) Polysaccharide (De-O-Acetylated) Conjugated To Tetanus Toxoid) supplied by GNH India

Neisvac-C

Active Ingredient:
N. Meningitidis Group C (Strain C11) Polysaccharide (De-O-Acetylated) Conjugated To Tetanus Toxoid
Origin:
EU

Neisvac-C (N. Meningitidis Group C (Strain C11) Polysaccharide (De-O-Acetylated) Conjugated To Tetanus Toxoid)

N. meningitidis group C (strain C11) polysaccharide (de-O-acetylated) conjugated to tetanus toxoid, the active ingredient in Neisvac-C, is a vaccine presented as an injectable solution for intramuscular use. It is used to prevent invasive disease caused by Neisseria meningitidis serogroup C in individuals at risk, such as adolescents, travelers and outbreak settings.

GNH India supplies Neisvac-C as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pfizer Aps

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Indications & Clinical Uses

Neisvac-C is a conjugate vaccine that targets the meningococcal disease pathway caused by serogroup C bacteria.

  • Meningococcal meningitis (serogroup C): reduces the risk of meningitis caused by Neisseria meningitidis group C.
  • Meningococcal septicemia (serogroup C): lowers the incidence of bloodstream infection due to serogroup C.
  • Meningococcal carriage (serogroup C): helps decrease nasopharyngeal carriage and transmission of the organism.

How It Works

  • The polysaccharide from Neisseria meningitidis group C is covalently linked to tetanus toxoid, creating a conjugate that is recognized by T‑helper cells. This T‑cell‑dependent presentation stimulates robust IgG antibody production and immunological memory, providing active protection against future exposure to serogroup C meningococci.

Side Effects

Neisvac-C may cause local and systemic reactions after injection.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the site of administration.
  • Redness or swelling: localized erythema or edema.
  • Fever: transient low‑grade temperature rise.
  • Headache or fatigue: mild systemic symptoms.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Guillain‑Barré syndrome: rare neurological disorder.
  • Severe hypotension or shock: may occur shortly after dosing.
  • Seizures: uncommon neurologic event.
  • Persistent high fever: prolonged temperature elevation.

Precautions & Warnings

Before administering Neisvac-C, consider the following safety measures.

  • Allergy assessment: avoid use in individuals with known hypersensitivity to any vaccine component.
  • Pregnancy: administer only if the expected benefit outweighs potential risk, as data are limited.
  • Immunocompromised patients: vaccine may be less effective; monitor immune response.
  • Concomitant vaccines: can be given at separate sites, but observe for additive local reactions.
  • Age restrictions: not recommended for children under the age specified in the product label.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Vaccines can interact with other agents that modify immune response.

Major Interactions (Avoid)

  • Severe allergic reaction to a previous dose: contraindicates further administration.
  • Immunoglobulin or blood products given within 4 weeks: may markedly reduce vaccine‑induced immunity.

Moderate Interactions (Monitor Closely)

  • Concurrent administration of other vaccines: monitor for increased local or systemic reactions.
  • Prophylactic antipyretics (e.g., acetaminophen): may blunt antibody response.
  • Ongoing immunosuppressive therapy: may lower vaccine efficacy, requiring serologic assessment.

Frequently Asked Questions

Neisvac-C is a conjugate vaccine indicated for the prevention of invasive disease caused by Neisseria meningitidis serogroup C. It is administered to individuals at risk, such as adolescents, travelers to endemic regions, and populations in outbreak settings, to protect against meningococcal meningitis, septicemia and carriage.

The active ingredient consists of a de‑O‑acetylated polysaccharide from N. meningitidis group C chemically linked to tetanus toxoid. This conjugation creates a T‑cell‑dependent antigen that elicits a strong IgG antibody response and immunologic memory, thereby providing active protection against future exposure to serogroup C meningococci.

The dosing regimen for Neisvac-C is determined by the prescribing healthcare professional based on the patient’s age, risk factors and local immunization guidelines. The prescriber will specify the number of doses, interval between doses and any booster requirements.

Safety data for Neisvac-C in pregnancy are limited, so it should be used only when the potential benefit justifies any possible risk to the fetus. There is no specific contraindication for breastfeeding, but the decision should be made in consultation with a qualified health professional.

To place an order, submit an enquiry on the Neisvac-C product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.

Neisvac-C is a serogroup‑specific conjugate vaccine targeting only N. meningitidis group C, whereas broader vaccines such as Menactra or Menveo protect against multiple serogroups (A, C, W, Y). The conjugate technology in Neisvac-C provides a T‑cell‑dependent response, which generally yields longer‑lasting immunity compared with plain polysaccharide vaccines.

Neisvac-C must be stored refrigerated at 2 °C to 8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. If the cold chain is broken, discard the product according to local regulations.

Neisvac-C is supplied as an injectable solution for intramuscular injection, typically into the deltoid muscle of the upper arm. The administration is performed by a qualified healthcare professional using aseptic technique.

The most serious adverse events reported with Neisvac-C include anaphylaxis, severe allergic reactions, Guillain‑Barré syndrome, and rare neurologic complications such as seizures. Immediate medical attention is required if any of these symptoms develop after vaccination.

Neisvac-C should not be given to individuals with a documented severe allergy to any component of the vaccine or to those who have experienced a previous anaphylactic reaction to a dose of the same vaccine. It is also contraindicated in persons for whom the product label specifies age restrictions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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