Product image of Neisvac-C (N. Meningitidis Group C (Strain C11) Polysaccharide (De-O-Acetylated) Conjugated To Tetanus Toxoid) supplied by GNH India

Neisvac-C

Active Ingredient:
N. Meningitidis Group C (Strain C11) Polysaccharide (De-O-Acetylated) Conjugated To Tetanus Toxoid
Origin:
EU

Neisvac-C (N. Meningitidis Group C (Strain C11) Polysaccharide (De-O-Acetylated) Conjugated To Tetanus Toxoid)

N. meningitidis group C (strain C11) polysaccharide (de‑O‑acetylated) conjugated to tetanus toxoid, the active ingredient in Neisvac‑C, is a vaccine presented as an injectable solution for intramuscular use. It induces immunity that helps prevent invasive disease caused by Neisseria meningitidis serogroup C in at‑risk individuals such as adolescents, travelers and those with complement deficiencies.

GNH India supplies Neisvac‑C as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing regulatory‑approved batches and cold‑chain logistics for global immunisation programmes.

Manufacturer / TM Owner

Pfizer B.V.

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Indications & Clinical Uses

Neisvac‑C is a conjugate vaccine used to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroup C.

  • Invasive meningococcal disease (serogroup C): provides active immunity to reduce incidence.
  • Outbreak control (serogroup C): used in mass vaccination campaigns to halt transmission.
  • High‑risk groups (e.g., complement deficiency, asplenia, travelers to endemic areas): offers protection against serogroup C infection.

How It Works

  • The polysaccharide capsule of Neisseria meningitidis group C is chemically linked to tetanus toxoid, converting the antigen into a T‑cell‑dependent form. This conjugate stimulates helper T‑cells, leading to robust B‑cell activation and the production of high‑affinity, class‑switched antibodies that recognize the group C capsular polysaccharide, facilitating opsonophagocytic killing of the bacteria.

Side Effects

Neisvac‑C is generally well tolerated, but injection‑related and systemic reactions can occur.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or swelling: localized erythema or edema.
  • Fever: transient low‑grade temperature rise.
  • Headache or malaise: general feeling of unease.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Guillain‑Barré syndrome: rare demyelinating neuropathy reported post‑vaccination.

Precautions & Warnings

Before administering Neisvac‑C, consider the following precautions.

  • Contraindication: known hypersensitivity to any vaccine component.
  • Caution: evaluate for severe immunodeficiency before use.
  • Pregnancy: safety not established; weigh benefits against potential risks.
  • Breastfeeding: insufficient data; consider risk‑benefit assessment.
  • Age: not recommended for children under 2 years unless specifically indicated.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Neisvac‑C may interact with other immunizations or immune‑modulating therapies.

Major Interactions (Avoid)

  • Live attenuated vaccines: avoid administration within 4 weeks before or after Neisvac‑C.
  • Immunoglobulin therapy: may blunt antibody response if given within 2 weeks of vaccination.

Moderate Interactions (Monitor Closely)

  • Other inactivated vaccines: can be co‑administered but monitor for increased reactogenicity.
  • Antipyretics: prophylactic use may reduce immune response; use only if needed.
  • Corticosteroids: high‑dose therapy may diminish vaccine efficacy.

Frequently Asked Questions

Neisvac‑C is a conjugate vaccine indicated for the prevention of invasive disease caused by Neisseria meningitidis serogroup C. It is administered to individuals at risk, such as adolescents, travelers to endemic regions, and persons with certain immune deficiencies, to reduce the incidence of meningococcal infection.

The active ingredient consists of the group C capsular polysaccharide chemically linked to tetanus toxoid. This conjugation converts the polysaccharide into a T‑cell‑dependent antigen, prompting helper T‑cell activation, which drives a strong B‑cell response and the production of high‑affinity antibodies that target the bacterial capsule.

The dosing regimen for Neisvac‑C is determined by the prescribing healthcare professional based on the patient’s age, health status, and local immunisation guidelines. The prescriber will specify the number of doses, interval between doses, and any booster requirements.

Safety data for Neisvac‑C in pregnancy and lactation are limited. The vaccine should only be used when the potential benefit to the mother outweighs any uncertain risk to the fetus or infant. Healthcare providers should discuss individual circumstances with the patient.

To order Neisvac‑C, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.

Neisvac‑C is a monovalent group C conjugate vaccine, whereas some alternatives, such as quadrivalent conjugate vaccines, protect against additional serogroups (A, W, Y). Neisvac‑C offers a focused immune response to serogroup C and may be preferred in settings where that serogroup predominates or when a single‑serogroup formulation is required.

Neisvac‑C must be stored refrigerated at 2 °C to 8 °C. It should be kept in the original packaging, protected from light, and must not be frozen or shaken. Maintaining the cold chain during transport and storage is essential to preserve vaccine potency.

Neisvac‑C is supplied as an injectable solution for intramuscular injection, typically into the deltoid muscle. The administration is performed by a qualified healthcare professional using aseptic technique, following the dosing schedule prescribed for the individual patient.

The most serious adverse events reported with Neisvac‑C include severe allergic reactions such as anaphylaxis and, rarely, Guillain‑Barré syndrome. Immediate medical attention is required if signs of a severe allergic reaction occur, and patients should be observed after vaccination according to standard practice.

Neisvac‑C should not be given to individuals with a known hypersensitivity to any component of the vaccine, including the tetanus toxoid carrier. It is also contraindicated in persons who have experienced a severe allergic reaction to a previous dose of the same vaccine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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