Product image of Neisvac-C (N. Meningitidis Group C (Strain C11) Polysaccharide (De-O-Acetylated) Conjugated To Tetanus Toxoid A) supplied by GNH India

Neisvac-C

Active Ingredient:
N. Meningitidis Group C (Strain C11) Polysaccharide (De-O-Acetylated) Conjugated To Tetanus Toxoid A
Origin:
EU

Neisvac-C (N. Meningitidis Group C (Strain C11) Polysaccharide (De-O-Acetylated) Conjugated To Tetanus Toxoid A)

N. meningitidis Group C (Strain C11) Polysaccharide (De-O-Acetylated) Conjugated To Tetanus Toxoid A, the active ingredient in Neisvac-C, is a vaccine presented as a vaccine for intramuscular use. It is used to prevent invasive disease caused by Neisseria meningitidis serogroup C, primarily in children, adolescents and adults at risk.

GNH India supplies Neisvac-C as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pfizer S.A.

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Indications & Clinical Uses

Neisvac-C is a meningococcal group C conjugate vaccine indicated for prevention of invasive disease caused by Neisseria meningitidis serogroup C.

  • Invasive meningococcal disease: provides active immunity to reduce the risk of meningitis and septicemia caused by serogroup C.
  • Outbreak control: used in mass vaccination campaigns to curb serogroup C outbreaks.
  • Travel to endemic areas: protects travelers visiting regions where serogroup C is prevalent.

How It Works

  • Neisvac-C contains polysaccharide from Neisseria meningitidis group C chemically linked to tetanus toxoid. The conjugate is taken up by antigen‑presenting cells, processed, and presented to T cells, which stimulate B‑cell production of high‑affinity IgG antibodies against the group C capsular polysaccharide, establishing long‑lasting protective immunity.

Side Effects

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or swelling: localized erythema or edema.
  • Fever: transient low‑grade temperature rise.
  • Headache or fatigue: mild systemic symptoms.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Guillain‑Barré syndrome: rare neurological disorder.
  • Seizures: infrequent neurologic event post‑vaccination.

Precautions & Warnings

Neisvac-C should be administered only after evaluating individual risk factors.

  • Pregnancy: use only if the potential benefit justifies the potential risk to the fetus.
  • Breastfeeding: generally considered safe, but weigh benefits against any unknown risks.
  • Immunocompromised individuals: vaccine may elicit a reduced immune response.
  • Prior severe allergic reaction to any vaccine component: contraindicates further doses.
  • Age: recommended for individuals from 2 months of age onward according to local immunisation schedules.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Vaccination timing may need adjustment when other agents are used.

Major Interactions (Avoid)

  • Live viral vaccines: avoid simultaneous administration as immune interference may occur.
  • Immunoglobulin therapy: may neutralise the vaccine antigen and reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Antipyretics (e.g., acetaminophen, ibuprofen): may reduce fever but do not significantly affect immunogenicity.
  • Immunosuppressive drugs (e.g., corticosteroids, chemotherapy): may diminish antibody response.
  • Blood products or plasma: may interfere with vaccine‑induced immunity if given shortly before or after vaccination.

Frequently Asked Questions

Neisvac-C is a conjugate vaccine designed to prevent invasive disease caused by Neisseria meningitidis serogroup C. It is administered to individuals at risk of meningococcal infection, including children, adolescents, adults, and travelers to areas where serogroup C is endemic.

The vaccine contains a de‑O‑acetylated polysaccharide from N. meningitidis group C linked to tetanus toxoid. This conjugate is recognized by the immune system, prompting T‑cell help and stimulating B‑cells to produce high‑affinity IgG antibodies that neutralise the bacteria and provide long‑lasting protection.

The specific dosing schedule for Neisvac-C is determined by the prescribing clinician based on age, local immunisation guidelines, and risk factors. Typically, a primary series followed by booster doses is recommended, but the exact regimen should be confirmed by a qualified health professional.

Safety data in pregnancy are limited, so the vaccine should be used only if the expected benefit outweighs potential risks. Breastfeeding is not a contraindication; the vaccine can be administered while nursing, but clinicians should consider individual circumstances.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.

Neisvac-C is a conjugate vaccine targeting serogroup C, offering T‑cell‑dependent immunity and longer‑lasting protection compared with plain polysaccharide vaccines. It differs from quadrivalent conjugate vaccines that also cover serogroups A, W and Y, making it a focused option when only serogroup C protection is needed.

Neisvac-C must be stored refrigerated between 2 °C and 8 °C. It should be kept in its original packaging, protected from light, and must never be frozen or shaken. Maintaining the cold chain during transport and storage is essential to preserve vaccine potency.

The vaccine is given by intramuscular injection, usually into the deltoid muscle of the upper arm. Administration is performed by a qualified healthcare professional following aseptic technique and the dosing schedule prescribed by the clinician.

The most serious adverse events include severe allergic reactions such as anaphylaxis, rare neurological conditions like Guillain‑Barré syndrome, and, in very uncommon cases, seizures. Immediate medical attention is required if any of these symptoms appear after vaccination.

Individuals with a known severe allergy to any component of the vaccine, including the tetanus toxoid carrier, should not receive Neisvac-C. It is also contraindicated in persons who have experienced a previous anaphylactic reaction to a meningococcal conjugate vaccine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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