Product image of Neldivex (Nebivolol) supplied by GNH India

Neldivex

Active Ingredient:
Nebivolol
Origin:
EU

Neldivex (Nebivolol)

Nebivolol, the active ingredient in Neldivex, is a beta blocker presented as a tablet for oral use. It selectively lowers elevated blood pressure in adult patients with primary hypertension and is approved for long‑term management of this condition.\n\nGNH India supplies Neldivex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing EU‑conformant quality for global markets.

Manufacturer / TM Owner

Alkaloid-Int D.O.O.

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Indications & Clinical Uses

  • Nebivolol is a β1‑selective blocker used in the management of hypertension.\n\nHypertension: reduces systolic and diastolic blood pressure in adults with primary (essential) hypertension.

How It Works

  • Nebivolol binds selectively to β1‑adrenergic receptors on cardiac myocytes, inhibiting sympathetic stimulation and decreasing heart rate and contractility. In addition, it enhances endothelial nitric oxide release, producing vasodilation that further contributes to blood‑pressure reduction. The combined β‑blockade and nitric‑oxide‑mediated effects result in a sustained antihypertensive response without significant β2‑receptor antagonism.

Side Effects

  • Nebivolol may cause a range of adverse reactions, most of which are dose‑related and reversible.\n\nCommon Side Effects:\n- Headache: mild to moderate intensity, often transient.\n- Dizziness or light‑headedness: especially on standing.\n- Fatigue or tiredness: generally improves with continued therapy.\n- Nasal congestion: occasional mild stuffiness.\n- Gastrointestinal discomfort: mild nausea or abdominal pain.\n\nSerious or Rare Side Effects:\n- Bradycardia: heart rate markedly below normal, requiring medical assessment.\n- Severe hypotension: sudden drop in blood pressure with risk of syncope.\n- Acute heart failure exacerbation: worsening symptoms in susceptible patients.\n- Bronchospasm: especially in patients with underlying asthma or COPD.\n- Allergic reactions: rash, pruritus, or angioedema.

Precautions & Warnings

  • Nebivolol should be used with caution in specific clinical situations and patient populations.\n\nContraindicated in patients with severe bradycardia: avoid use if resting heart rate is <50 bpm.\nCaution in asthma or chronic obstructive pulmonary disease: monitor for bronchospasm.\nUse carefully in hepatic impairment: dose adjustment may be required.\nAvoid abrupt discontinuation: taper gradually to prevent rebound hypertension.\nMonitor blood pressure and heart rate regularly during therapy.\nStore at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Avoid Interactions

  • Nebivolol can interact with several drug classes, altering its efficacy or safety profile.\n\nMajor Interactions (Avoid):\n- Combined use with other β‑blockers: risk of excessive β‑blockade and severe bradycardia.\n- Concomitant strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase nebivolol plasma levels.\n- Severe hypotensive agents (e.g., potent vasodilators): can cause marked blood‑pressure fall.\n\nModerate Interactions (Monitor Closely):\n- Other antihypertensives (ACE inhibitors, ARBs, diuretics): may require dose adjustment.\n- Calcium‑channel blockers (especially verapamil, diltiazem): can enhance bradycardic effect.\n- Antidiabetic medications: nebivolol may mask hypoglycaemia symptoms; monitor glucose closely.

Frequently Asked Questions

Neldivex contains nebivolol, a β1‑selective blocker indicated for the treatment of primary (essential) hypertension in adult patients. It helps lower elevated systolic and diastolic blood pressure, reducing the risk of cardiovascular complications associated with uncontrolled hypertension.

Nebivolol blocks β1‑adrenergic receptors in the heart, decreasing heart rate and contractile force, which lowers cardiac output. Additionally, it stimulates endothelial nitric oxide release, causing vasodilation of peripheral vessels. The combined actions result in a sustained reduction of blood pressure.

The appropriate dose of Neldivex is determined by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy, and any relevant comorbidities. Dosage adjustments may be needed for special populations such as those with hepatic impairment.

The safety of nebivolol in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Neldivex product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nebivolol offers β1‑selective blockade combined with nitric‑oxide‑mediated vasodilation, which can provide better tolerability regarding metabolic effects compared with non‑selective β‑blockers. Unlike some calcium‑channel blockers, it does not cause significant peripheral edema, making it a useful alternative for patients who experience that side effect.

Neldivex tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Neldivex is taken orally, usually once daily with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically advised.

Serious risks include severe bradycardia, marked hypotension, acute heart‑failure exacerbation, and bronchospasm in patients with asthma or COPD. Patients should be monitored for these events, especially during treatment initiation or dose adjustments.

Neldivex is contraindicated in patients with severe bradycardia (resting heart rate <50 bpm), second‑ or third‑degree atrioventricular block without a pacemaker, and in those with known hypersensitivity to nebivolol or any tablet excipients. Caution is also advised for individuals with significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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