Product image of Nelova (Ethinylestradiol, Etonogestrel) supplied by GNH India

Nelova

Active Ingredient:
Ethinylestradiol, Etonogestrel
Origin:
EU

Nelova (Ethinylestradiol, Etonogestrel)

Ethinylestradiol/Etonogestrel, the active ingredient in Nelova, is a combined estrogen‑progestogen contraceptive presented as a vaginal ring for vaginal use. It provides reversible contraception for women of reproductive age.

GNH India supplies Nelova as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Bailleul S.A.

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Indications & Clinical Uses

  • Nelova, a combined estrogen‑progestogen contraceptive, is indicated for prevention of pregnancy.
  • Contraception: provides reliable, reversible birth control for women of childbearing potential.
  • Menstrual cycle regulation: helps establish a more predictable menstrual pattern.
  • Reduced menstrual bleeding: may lessen the volume of menstrual blood loss.

How It Works

  • Ethinylestradiol and etonogestrel act on the hypothalamic‑pituitary‑ovarian axis. Ethinylestradiol suppresses follicle‑stimulating hormone, while etonogestrel inhibits luteinizing hormone, preventing ovulation. The progestogen also thickens cervical mucus and induces endometrial changes that reduce the likelihood of implantation.

Side Effects

Nelova may cause a range of adverse reactions.

Common Side Effects

  • Headache
  • Nausea or vomiting
  • Breast tenderness
  • Mood changes or irritability
  • Vaginal irritation or discharge
  • Spotting between periods

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism
  • Stroke or transient ischemic attack
  • Myocardial infarction
  • Severe allergic reaction (anaphylaxis)
  • Liver tumor or severe hepatic dysfunction
  • Elevated blood pressure or hypertension crisis

Precautions & Warnings

Before prescribing Nelova, clinicians should evaluate individual risk factors.

  • Assess thrombotic risk: avoid in women with a history of venous thromboembolism.
  • Screen for hypertension: monitor blood pressure regularly.
  • Review smoking status: contraindicated in smokers over 35 years.
  • Evaluate liver function: avoid in severe hepatic disease.
  • Consider drug interactions: review concomitant enzyme‑inducing medications.
  • Store at ambient temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Nelova can interact with several medication classes.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly reduce contraceptive efficacy.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase hormone exposure and risk of side effects.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline, metronidazole): may slightly lower effectiveness.
  • Anticonvulsants (e.g., phenytoin, phenobarbital): may decrease hormone levels.
  • Herbal supplements (e.g., St. John’s wort): may reduce contraceptive reliability.

Frequently Asked Questions

Nelova is a prescription vaginal ring that delivers a combined estrogen‑progestogen formulation to prevent pregnancy. It is intended for use by women of reproductive age who seek a reversible, long‑acting contraceptive method.

The ring releases ethinyloestradiol and etonogestrel, which suppress the release of follicle‑stimulating and luteinizing hormones, thereby inhibiting ovulation. The progestogen also thickens cervical mucus and alters the endometrial lining, creating multiple barriers to fertilisation and implantation.

Nelova is supplied as a pre‑filled vaginal ring that is inserted by the user and left in place for three weeks, followed by a one‑week ring‑free interval. The exact dosing schedule is determined by the prescribing clinician based on individual health factors.

Nelova is contraindicated during pregnancy because it is intended to prevent conception. If pregnancy occurs, the ring should be removed immediately. Use during breastfeeding is generally not recommended without medical advice, as hormonal exposure may affect milk production.

To request Nelova, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nelova delivers hormones via a vaginal ring, offering steady plasma levels and a three‑week wear schedule, unlike daily oral pills that require strict adherence. Compared with transdermal patches, the ring is less visible and may cause fewer skin‑related reactions, while providing comparable contraceptive efficacy.

Nelova should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from direct sunlight, moisture and excessive heat to maintain its integrity throughout its shelf life.

The ring is inserted into the vagina by the user or a healthcare professional and left in place for three consecutive weeks. After a one‑week break, a new ring is inserted to continue contraception. No additional dosing is required during the wear period.

Serious risks include venous thromboembolism, pulmonary embolism, stroke, myocardial infarction, severe allergic reactions, and hepatic disorders. Women with a history of clotting disorders, smoking over age 35, uncontrolled hypertension, or certain liver diseases should avoid using Nelova.

Nelova is contraindicated in women with a known or suspected pregnancy, active or past thromboembolic disease, uncontrolled hypertension, severe liver disease, breast cancer, or in smokers over 35 years of age. It should also be avoided in individuals with known hypersensitivity to any component of the ring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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