Neo Borocillina Gola Dolore Gusto Menta (Flurbiprofen)

Flurbiprofen is an NSAID that reduces inflammation and pain in the upper respiratory mucosa.

• Sore throat: provides rapid relief of pain and inflammation associated with acute pharyngitis.
• Mouth ulcer discomfort: alleviates burning and irritation from minor oral lesions.
• Post‑operative throat irritation: reduces discomfort after minor throat procedures or surgeries.

• Flurbiprofen non‑selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, blocking the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces inflammation, edema, and nociceptive signaling in the oropharyngeal tissues, producing analgesic and anti‑inflammatory effects at the site of application.

Common Side Effects

• Local mouth irritation or burning sensation.
• Altered taste or minty after‑taste.
• Nausea or mild gastrointestinal discomfort.
• Headache.
• Dizziness.
• Mild dyspepsia.

Serious or Rare Side Effects

• Allergic reactions such as angioedema or anaphylaxis.
• Gastrointestinal ulceration or bleeding.
• Severe liver enzyme elevation.
• Renal impairment or acute kidney injury.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Hematologic abnormalities such as thrombocytopenia.

Flurbiprofen should be used with caution in patients with certain medical conditions and in specific situations.

• Gastro‑intestinal history: assess for ulcer disease or bleeding risk before use.
• Cardiovascular risk: avoid in patients with uncontrolled hypertension or recent myocardial infarction.
• Renal function: monitor kidney parameters in patients with existing renal impairment.
• Known NSAID hypersensitivity: contraindicated in individuals with documented allergy to NSAIDs.
• Pregnancy and lactation: use only if clearly indicated and after professional assessment.
• Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Flurbiprofen may interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Corticosteroids: heightened risk of ulceration and bleeding.
• Selective serotonin reuptake inhibitors (SSRIs): potential for enhanced bleeding.
• ACE inhibitors or ARBs: may impair renal function when combined.

Moderate Interactions (Monitor Closely)

• Diuretics: possible reduction in antihypertensive effect.
• Lithium: NSAIDs can raise lithium serum levels.
• Methotrexate: decreased clearance leading to toxicity.
• Cyclosporine: increased nephrotoxicity risk.
• Beta‑blockers: may blunt antihypertensive response.