Neo Borocillina Gola Dolore Senza Zucchero Gusto Limone E Miele (Flurbiprofen)

Flurbiprofen acts as an NSAID that reduces inflammation and pain in several common conditions.

• Sore throat pain: provides rapid symptomatic relief of throat discomfort caused by inflammation.
• Mild to moderate musculoskeletal pain: alleviates aches and stiffness associated with strains, sprains or overuse.
• General inflammation: helps reduce localized swelling and tenderness in affected tissues.

• Flurbiprofen reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, blocking the conversion of arachidonic acid to prostaglandins. By lowering prostaglandin synthesis, it diminishes inflammatory mediators, resulting in reduced pain, fever and edema at the site of tissue injury. The inhibition is dose‑dependent and occurs throughout the body, providing systemic anti‑inflammatory and analgesic effects while preserving platelet function at therapeutic concentrations.

Flurbiprofen may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

• Dyspepsia or stomach upset
• Nausea or vomiting
• Headache
• Dizziness

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration
• Severe allergic reactions such as rash, angioedema or anaphylaxis
• Liver enzyme elevation or hepatitis
• Renal impairment or sudden loss of kidney function

When using flurbiprofen, several safety considerations should be observed to minimize risk.

• Assess gastrointestinal risk: avoid use in patients with active ulcers or a history of serious GI bleeding.
• Monitor renal function: use cautiously in individuals with impaired kidney function or dehydration.
• Evaluate cardiovascular status: consider risk in patients with hypertension, heart failure or prior thrombotic events.
• Avoid concomitant NSAIDs: do not combine with other non‑steroidal anti‑inflammatory drugs or aspirin without medical guidance.
• Pregnancy and lactation: use only if clearly indicated after professional assessment.
• Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Flurbiprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Selective COX‑2 inhibitors: additive gastrointestinal toxicity.
• Corticosteroids: heightened chance of ulceration or GI bleeding.
• Methotrexate (high dose): reduced clearance leading to toxicity.
• Lithium: possible increase in lithium serum levels.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce renal perfusion, especially in volume‑depleted patients.
• Diuretics: potential for reduced kidney function when combined.
• SSRIs or SNRIs: modestly increased bleeding risk.
• Antihypertensives: NSAIDs may blunt antihypertensive effect.