Neo Borocillina Gola Dolore Senza Zucchero Gusto Menta (Flurbiprofen)

Flurbiprofen acts systemically to reduce pain and inflammation in several common conditions.

• Sore throat pain: provides rapid relief of throat discomfort caused by inflammation.
• Mild to moderate pain: eases aches such as dental or musculoskeletal pain.
• Inflammation: reduces localized swelling in tissues affected by inflammatory processes.

• Flurbiprofen reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis diminishes inflammatory mediators, leading to lowered pain perception and swelling at the site of inflammation.

Flurbiprofen may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Skin rash or mild itching.
• Elevated blood pressure.
• Mild renal function changes.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Severe hepatic injury.
• Anaphylactic reactions or severe skin eruptions.
• Cardiovascular events such as myocardial infarction.
• Severe renal impairment.
• Blood dyscrasias including agranulocytosis.

When using Flurbiprofen, consider the following safety measures.

• Assess gastrointestinal risk: avoid use in patients with active ulcers or a history of GI bleeding.
• Monitor cardiovascular status: use cautiously in individuals with heart disease.
• Evaluate renal function: adjust use in patients with impaired kidney function.
• Check for hypersensitivity: discontinue if allergic reactions occur.
• Avoid concurrent NSAIDs: increase risk of adverse effects.
• Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Flurbiprofen can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
• Corticosteroids: synergistic ulcerogenic effect.

Moderate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: possible reduction in antihypertensive effect.

• Diuretics: may impair renal function.
• Lithium: increased serum lithium levels.
• Methotrexate: reduced clearance leading to toxicity.