Product image of Neo-Egmol (Ketoconazole) supplied by GNH India

Neo-Egmol

Active Ingredient:
Ketoconazole
Origin:
EU

Neo-Egmol (Ketoconazole)

Ketoconazole, the active ingredient in Neo-Egmol, is an imidazole antifungal presented as a topical formulation for skin use. It treats fungal infections such as tinea corporis, tinea cruris, seborrheic dermatitis, and pityriasis versicolor in both adults and children.

GNH India supplies Neo-Egmol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Target Pharma Single Member Private Ltd

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Indications & Clinical Uses

Ketoconazole is an imidazole antifungal that targets dermatophyte and yeast infections of the skin.

  • Tinea corporis: reduces erythema, scaling and itching caused by dermatophyte infection.
  • Tinea cruris: alleviates rash and discomfort in the groin area.
  • Seborrheic dermatitis: controls flaking, redness and itching on scalp and face.
  • Pityriasis versicolor: clears discolored patches caused by Malassezia species.

How It Works

  • Ketoconazole inhibits fungal sterol (ergosterol) synthesis by blocking the enzyme lanosterol 14α-demethylase. This disruption impairs cell membrane formation, leading to increased permeability and ultimately fungal cell death. The action is selective for fungal cells, sparing human cholesterol pathways.

Side Effects

Common Side Effects

  • Skin irritation: mild burning or stinging at the application site.
  • Itching: transient pruritus during early treatment.
  • Redness: localized erythema.
  • Dryness: temporary loss of skin moisture.
  • Scaling: mild flaking of the treated area.
  • Sensation of tightness: brief feeling of tight skin.

Serious or Rare Side Effects

  • Allergic contact dermatitis: severe rash, swelling or blistering.
  • Stevens‑Johnson syndrome: rare, life‑threatening skin reaction.
  • Photosensitivity: increased susceptibility to sunburn.
  • Systemic absorption leading to hepatic dysfunction: very uncommon but reported with extensive use.

Precautions & Warnings

Before using Neo‑Egmol, consider the following precautions:

  • Avoid application on broken or inflamed skin: may increase irritation.
  • Do not apply near eyes or mucous membranes: risk of severe irritation.
  • Use only for the indicated fungal conditions: off‑label use is not recommended.
  • Monitor for signs of allergic reaction: discontinue if severe rash develops.
  • Keep out of reach of children: accidental ingestion can cause systemic effects.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ketoconazole can interact with other agents when applied to the skin.

Major Interactions (Avoid)

  • Systemic azole antifungals (e.g., itraconazole): may increase systemic exposure.
  • Oral corticosteroids: combined use may raise risk of adrenal suppression.
  • Warfarin: topical ketoconazole may potentiate anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Topical retinoids: may enhance skin irritation.
  • Sunscreen agents: potential for increased photosensitivity.
  • Other antifungal creams: overlapping toxicity should be assessed.

Frequently Asked Questions

Neo‑Egmol is indicated for the topical treatment of superficial fungal infections such as tinea corporis (ringworm of the body), tinea cruris (jock itch), seborrheic dermatitis (scalp and facial flaking), and pityriasis versicolor (discolored skin patches).

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for synthesising ergosterol, a key component of the fungal cell membrane. Inhibiting this pathway disrupts membrane integrity, leading to fungal cell death.

The prescribed amount, frequency, and duration of Neo‑Egmol application are set by the treating healthcare professional based on the specific infection, its severity, and the patient’s age and skin condition.

Safety data for topical ketoconazole during pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against any possible risks before prescribing Neo‑Egmol to pregnant or nursing individuals.

To order Neo‑Egmol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ketoconazole and clotrimazole belong to the imidazole class and share a similar spectrum against dermatophytes and yeasts. Ketoconazole often has broader activity against certain resistant strains, while clotrimazole may be preferred for milder infections due to its lower irritation potential.

Store Neo‑Egmol at room temperature, ideally below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Clean and gently dry the affected area before applying a thin layer of Neo‑Egmol. Rub it in lightly until it disappears, and wash hands after use. Follow the prescriber’s instructions regarding frequency and total duration of therapy.

Serious risks, though rare, include severe allergic reactions such as contact dermatitis, Stevens‑Johnson syndrome, and systemic effects like hepatic dysfunction if significant absorption occurs. Immediate medical attention is required if these symptoms develop.

Neo‑Egmol should be avoided in individuals with known hypersensitivity to ketoconazole or any component of the formulation, on extensive broken skin, and in patients where systemic absorption could pose a risk, such as those with severe liver disease, unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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