Product image of Neo-Endusix (Tenoxicam) supplied by GNH India

Neo-Endusix

Active Ingredient:
Tenoxicam
Origin:
EU

Neo-Endusix (Tenoxicam)

Tenoxicam, the active ingredient in Neo-Endusix, is a oxicam presented as a injection for intramuscular, intravenous use. It treats rheumatoid arthritis, osteoarthritis, acute musculoskeletal pain and post‑operative pain in adult patients.

GNH India supplies Neo-Endusix as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Anfarm Hellas Sa

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Indications & Clinical Uses

  • Tenoxicam is an oxicam NSAID used to manage inflammatory and painful conditions affecting the musculoskeletal system.
  • Rheumatoid arthritis: reduces joint inflammation and pain.
  • Osteoarthritis: alleviates chronic joint discomfort and swelling.
  • Acute musculoskeletal pain: provides rapid relief of pain and inflammation.
  • Post‑operative pain: controls postoperative inflammatory pain.

How It Works

  • Tenoxicam inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. By reducing prostaglandin levels, it dampens the inflammatory cascade and provides analgesic and antipyretic effects.

Side Effects

Tenoxicam may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal irritation or dyspepsia.
  • Nausea.
  • Headache.
  • Injection‑site pain or mild erythema.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Severe hepatic injury.
  • Anaphylactic reaction.
  • Blood dyscrasias such as agranulocytosis.
  • Cardiovascular thrombotic events.

Precautions & Warnings

  • Tenoxicam should be used with caution in patients with certain conditions.
  • Assess renal function: avoid or adjust use in severe renal impairment.
  • Monitor hepatic enzymes: contraindicated in severe liver disease.
  • Evaluate cardiovascular risk: use cautiously in patients with heart disease.
  • Review concomitant NSAIDs or anticoagulants: increased bleeding risk.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Tenoxicam can interact with several medicines, requiring attention.

Major Interactions (Avoid)

  • Warfarin: heightened bleeding risk.
  • Lithium: increased serum lithium concentrations.
  • Methotrexate: enhanced toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible decline in renal function.
  • Diuretics: risk of reduced renal clearance.
  • SSRIs or SNRIs: increased bleeding tendency.

Frequently Asked Questions

Neo-Endusix, containing Tenoxicam, is indicated for rheumatoid arthritis, osteoarthritis, acute musculoskeletal pain and post‑operative pain, where reduction of inflammation and pain is required.

Tenoxicam blocks cyclooxygenase enzymes (COX‑1 and COX‑2), which reduces the production of prostaglandins—key mediators of inflammation, pain and fever—thereby providing anti‑inflammatory and analgesic effects.

The prescribed dose of Neo-Endusix is determined by the treating physician based on the patient’s condition, severity, and clinical response. Dosing regimens are individualized and should follow the prescriber’s instructions.

Safety data for Tenoxicam in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Neo-Endusix product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Tenoxicam belongs to the oxicam class, offering a longer half‑life than many traditional NSAIDs, which may allow less frequent dosing. Its efficacy in reducing inflammation is comparable to other potent NSAIDs, but individual tolerability and safety profiles can differ.

Neo-Endusix should be stored at ambient temperature, below 25 °C, in its original packaging, protected from moisture and direct light to maintain stability.

Neo-Endusix is supplied as a sterile injection and can be given either intramuscularly or intravenously by a qualified healthcare professional, following aseptic technique and appropriate dosing guidelines.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, significant hepatic injury, anaphylaxis, blood dyscrasias, and increased risk of cardiovascular thrombotic events. Immediate medical attention is required if any of these occur.

Neo-Endusix should be avoided in patients with known hypersensitivity to Tenoxicam or other oxicams, in those with severe renal or hepatic impairment, and in individuals with active gastrointestinal ulceration or bleeding disorders unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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