Product image of Neoatricon (Dopamine Hydrochloride) supplied by GNH India

Neoatricon

Active Ingredient:
Dopamine Hydrochloride
Origin:
EU

Neoatricon (Dopamine Hydrochloride)

Dopamine Hydrochloride, the active ingredient in Neoatricon, is an inotropic agent presented as an injection solution for intravenous use. It treats hypotension, cardiogenic shock, septic shock, acute heart failure and other low cardiac output states in hospitalized patients, helping to stabilize cardiovascular function.

GNH India supplies Neoatricon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Brepco Biopharma Limited

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Indications & Clinical Uses

Neoatricon (dopamine hydrochloride) is used in cardiovascular emergencies to improve hemodynamic stability.

  • Hypotension: raises blood pressure by increasing cardiac output and peripheral resistance.
  • Cardiogenic shock: enhances myocardial contractility and systemic perfusion.
  • Septic shock: supports arterial pressure when fluids and other vasopressors are insufficient.
  • Acute heart failure: improves cardiac output and reduces symptoms of low output.
  • Low cardiac output states: stabilizes hemodynamics during surgery or critical illness.

How It Works

  • Dopamine hydrochloride acts as a dose‑dependent agonist of dopaminergic, β1‑adrenergic and α‑adrenergic receptors. At low doses it dilates renal vessels, at moderate doses it stimulates β1 receptors to increase heart rate and contractility, and at high doses it activates α receptors causing vasoconstriction, together raising cardiac output and arterial pressure.

Side Effects

Adverse reactions may occur with intravenous dopamine administration.

Common Side Effects

  • Tachycardia: increased heart rate.
  • Nausea or vomiting.
  • Headache.
  • Anxiety or restlessness.

Serious or Rare Side Effects

  • Myocardial ischemia or infarction.
  • Severe hypertension or hypertensive crisis.
  • Tissue necrosis at the infusion site.
  • Life‑threatening arrhythmias requiring intervention.
  • Pulmonary edema.
  • Anaphylactic or severe allergic reactions.

Precautions & Warnings

When using Neoatricon, careful monitoring and specific precautions are recommended.

  • Dose titration: adjust infusion rate based on real‑time blood pressure and cardiac output.
  • Renal function: monitor urine output and electrolytes during therapy.
  • Cardiac monitoring: observe for arrhythmias, ischemia, and excessive tachycardia.
  • Concomitant vasopressors: evaluate additive pressor effects and adjust doses accordingly.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Dopamine may interact with several drug classes; awareness of major and moderate interactions helps ensure safety.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Beta‑blockers: may blunt the inotropic response.
  • Alpha‑adrenergic antagonists: reduce vasoconstrictive effect.
  • Calcium channel blockers: additive hypotensive effect.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance electrolyte shifts.
  • ACE inhibitors or ARBs: monitor blood pressure closely.
  • Anticholinergic agents: may increase tachycardia.

Frequently Asked Questions

Neoatricon is an intravenous formulation of dopamine hydrochloride used in critical‑care settings to treat hypotension, cardiogenic shock, septic shock, acute heart failure and other low‑output cardiovascular conditions where rapid hemodynamic support is required.

Dopamine acts on dopaminergic, β1‑adrenergic and α‑adrenergic receptors in a dose‑dependent manner. Low doses cause renal vasodilation, moderate doses increase heart rate and contractility via β1 stimulation, and high doses produce peripheral vasoconstriction through α activation, collectively raising cardiac output and blood pressure.

The specific infusion rate of Neoatricon is individualized by the treating physician based on the patient’s blood pressure, cardiac output, and clinical response. Dosing is titrated in micrograms per kilogram per minute to achieve target hemodynamic goals.

Safety data for dopamine hydrochloride in pregnancy and lactation are limited. It should only be used when the potential maternal benefit justifies any possible risk to the fetus or infant, and the decision must be made by the prescriber.

To order Neoatricon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where applicable) and necessary import documentation.

Neoatricon (dopamine) provides both inotropic and vasopressor effects, whereas norepinephrine primarily offers potent vasoconstriction with less direct inotropic activity. Choice between them depends on the clinical scenario: dopamine may be preferred when renal perfusion support is desired, while norepinephrine is often used for pure vasoconstriction in septic shock.

Neoatricon must be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Before use, allow the solution to reach room temperature if required, and inspect for particulate matter or discoloration.

Neoatricon is given as an intravenous infusion. The vial is reconstituted with the appropriate diluent, then administered through a calibrated infusion pump. Continuous hemodynamic monitoring is essential while the infusion is titrated to the desired effect.

Serious risks include myocardial ischemia, severe hypertension or hypertensive crisis, life‑threatening arrhythmias, tissue necrosis at the infusion site, pulmonary edema, and anaphylactic reactions. Prompt recognition and intervention are critical if any of these events occur.

Neoatricon should be avoided in patients with known hypersensitivity to dopamine or any excipients, in those with uncontrolled tachyarrhythmias, severe ventricular dysfunction where excessive inotropy could be harmful, and in patients receiving MAO inhibitors without careful supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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