Product image of Neoatricon (Dopamine Hydrochloride) supplied by GNH India

Neoatricon

Active Ingredient:
Dopamine Hydrochloride
Origin:
EU

Neoatricon (Dopamine Hydrochloride)

Dopamine Hydrochloride, the active ingredient in Neoatricon, is a vasopressor presented as an injectable solution for intravenous use. It is employed to raise blood pressure and improve cardiac output in patients with hypotension, cardiogenic shock, acute heart failure, or renal perfusion deficits.

GNH India supplies Neoatricon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to healthcare institutions across multiple regions. Delivery is coordinated with local import requirements to ensure timely availability for critical care settings.

Manufacturer / TM Owner

Brepco Biopharma Limited

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Indications & Clinical Uses

Neoatricon (dopamine hydrochloride) acts on dopaminergic, beta‑1 adrenergic and alpha‑adrenergic pathways to support cardiovascular function.

  • Hypotension: Increases systemic vascular resistance and cardiac output to raise blood pressure.
  • Cardiogenic shock: Enhances myocardial contractility and perfusion to stabilize hemodynamics.
  • Acute heart failure: Improves stroke volume and organ perfusion during decompensation.
  • Renal perfusion support: Augments renal blood flow, aiding diuresis and kidney function in critical illness.

How It Works

  • Dopamine hydrochloride stimulates dopaminergic (D1) receptors at low doses, producing renal vasodilation; at intermediate doses it activates beta‑1 adrenergic receptors, increasing heart rate and contractility; at higher doses it engages alpha‑adrenergic receptors, causing vasoconstriction and raising systemic vascular resistance. The dose‑dependent receptor profile allows tailored support of cardiac output, blood pressure, and renal perfusion.

Side Effects

Common Side Effects

  • Tachycardia: Elevated heart rate due to beta‑1 stimulation.
  • Nausea or vomiting: Gastrointestinal irritation.
  • Headache: Resulting from rapid hemodynamic changes.
  • Anxiety or restlessness: Central nervous system activation.
  • Arrhythmia: Premature beats or ectopic rhythms.
  • Local infusion site irritation: Redness or mild pain.

Serious or Rare Side Effects

  • Myocardial ischemia: Reduced coronary perfusion from excessive demand.
  • Severe hypertension: Over‑activation of alpha receptors.
  • Tissue necrosis at infusion site: Extravasation injury.
  • Life‑threatening arrhythmias: Ventricular tachycardia or fibrillation.
  • Anaphylactic reaction: Rare hypersensitivity.
  • Pulmonary edema: Fluid overload in susceptible patients.

Precautions & Warnings

Neoatricon requires careful monitoring and individualized dosing.

  • Dose titration: Adjust infusion rate based on real‑time hemodynamic response.
  • Renal impairment: Monitor renal function and modify therapy as needed.
  • Cardiac arrhythmias: Use cautiously in patients with pre‑existing rhythm disorders.
  • Pregnancy: Administer only if potential benefits outweigh uncertain risks.
  • Drug interactions: Review concomitant vasoactive agents for additive effects.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Dopamine may interact with several cardiovascular agents.

Major Interactions (Avoid)

  • MAO inhibitors: Risk of hypertensive crisis.
  • Beta‑blockers: May blunt desired cardiac response.
  • Vasopressin: Additive vasoconstriction can cause severe hypertension.
  • Tricyclic antidepressants: Enhanced catecholamine effects increase cardiovascular stress.

Moderate Interactions (Monitor Closely)

  • Diuretics: May amplify hypotensive response when dopamine dose is low.
  • ACE inhibitors: Potential for unpredictable blood pressure fluctuations.

Frequently Asked Questions

Neoatricon (dopamine hydrochloride) is used in hospital settings to manage low blood pressure (hypotension), support circulation in cardiogenic shock, treat acute heart failure, and improve renal blood flow when organ perfusion is compromised.

Dopamine acts on three receptor families in a dose‑dependent way: low doses stimulate D1 receptors causing renal vasodilation, intermediate doses activate beta‑1 receptors to increase heart rate and contractility, and high doses engage alpha receptors leading to vasoconstriction and higher systemic resistance.

The specific infusion rate and total dose of Neoatricon are determined by the prescribing clinician based on the patient’s hemodynamic status, underlying condition, and response to therapy. Dosing is individualized and adjusted during treatment.

Safety data for dopamine hydrochloride in pregnancy and lactation are limited. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the Neoatricon product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Unlike pure alpha‑agonists, dopamine offers dose‑dependent effects that can improve renal perfusion at low doses and boost cardiac output at moderate doses. This versatility makes it useful in mixed‑shock states, whereas agents such norepinephrine primarily increase vascular tone without the renal benefits.

Neoatricon should be stored refrigerated between 2 °C and 8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution to maintain stability.

Neoatricon is supplied as a sterile injectable solution for intravenous infusion. It is administered through a controlled infusion pump or syringe driver, allowing precise titration of the rate according to the patient’s blood pressure and cardiac output measurements.

Serious risks include myocardial ischemia from excessive cardiac workload, severe hypertension due to high‑dose alpha‑adrenergic stimulation, life‑threatening arrhythmias, tissue necrosis if the solution extravasates, and rare anaphylactic reactions. Continuous monitoring is essential during therapy.

Neoatricon is contraindicated in patients with known hypersensitivity to dopamine or any formulation component, and it should be used with extreme caution—or avoided—in individuals with uncontrolled tachyarrhythmias, severe peripheral vascular disease, or those receiving MAO inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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