Product image of Neoatricon (Dopamine Hydrochloride) supplied by GNH India

Neoatricon

Active Ingredient:
Dopamine Hydrochloride
Origin:
EU

Neoatricon (Dopamine Hydrochloride)

Dopamine Hydrochloride, the active ingredient in Neoatricon, is a catecholamine presented as an injectable solution for intravenous use. It is employed to support cardiovascular function in patients with low blood pressure, cardiogenic shock, or acute heart failure, acting to improve cardiac output and renal perfusion.

GNH India supplies Neoatricon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with established quality‑assured distribution channels and regulatory compliance across EU and global markets, ensuring timely delivery and product integrity.

Manufacturer / TM Owner

Brepco Biopharma Limited

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Indications & Clinical Uses

Neoatricon, a catecholamine vasopressor, is used in the management of cardiovascular conditions characterized by low perfusion or impaired cardiac output.

  • Hypotension: Increases blood pressure by stimulating dopaminergic and β1‑adrenergic receptors, improving organ perfusion.
  • Cardiogenic shock: Enhances myocardial contractility and cardiac output, supporting circulation during acute pump failure.
  • Acute heart failure: Augments renal blood flow and reduces systemic vascular resistance at low doses, aiding decongestion and hemodynamic stability.

How It Works

  • Dopamine hydrochloride acts as a dose‑dependent agonist at dopaminergic (D1), β1‑adrenergic, and α1‑adrenergic receptors. Low infusion rates stimulate D1 receptors, causing renal and mesenteric vasodilation and increased glomerular filtration. Moderate doses activate β1 receptors, raising heart rate and contractility, while higher doses engage α1 receptors, producing peripheral vasoconstriction and elevation of systemic vascular resistance. These combined actions improve cardiac output and blood pressure in acute circulatory failure.

Side Effects

Dopamine infusion may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Tachycardia: rapid increase in heart rate.
  • Nausea or vomiting: gastrointestinal discomfort.
  • Headache: mild to moderate pain.

Serious or Rare Side Effects

  • Severe hypertension: dangerous rise in blood pressure.
  • Myocardial ischemia: reduced heart muscle blood flow.
  • Life‑threatening arrhythmias: ventricular tachycardia or fibrillation.

Precautions & Warnings

When using Neoatricon, clinicians should observe several precautionary measures to minimize risks.

  • Monitor blood pressure: check continuously during infusion.
  • Observe cardiac rhythm: watch for arrhythmias.
  • Adjust dose based on response: titrate to target hemodynamics.
  • Use cautiously in pheochromocytoma: risk of hypertensive crisis.
  • Avoid in uncorrected tachyarrhythmias: may exacerbate condition.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Dopamine may interact with other medications, requiring careful assessment before co‑administration.

Major Interactions (Avoid)

  • MAO inhibitors: may cause hypertensive crisis.
  • β‑blockers: can blunt dopamine’s inotropic effect.
  • α‑adrenergic antagonists: may reduce vasoconstrictive response.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: additive hypotensive effect.
  • Diuretics: may enhance volume depletion.
  • Other vasopressors: risk of excessive vasoconstriction.
  • Anesthetic agents: may alter cardiovascular response.

Frequently Asked Questions

Neoatricon contains dopamine hydrochloride and is used intravenously to treat severe hypotension, cardiogenic shock, and acute heart failure by improving cardiac output, blood pressure, and renal perfusion in critically ill patients.

Dopamine acts on dopaminergic, β1‑adrenergic and α1‑adrenergic receptors in a dose‑dependent manner. Low doses cause renal vasodilation, moderate doses increase heart contractility and rate, and high doses produce peripheral vasoconstriction, collectively supporting circulation.

The dosing regimen for Neoatricon is individualized. The prescribing clinician determines the infusion rate and duration based on the patient’s hemodynamic status, target blood pressure, and response to therapy.

Safety data for dopamine hydrochloride in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Neoatricon, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with agents such as norepinephrine, dopamine offers dose‑dependent renal vasodilation at low doses, which can be advantageous in patients needing improved kidney perfusion. However, its broader receptor profile may lead to more tachycardia and arrhythmias, so selection depends on the clinical scenario.

Neoatricon should be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the solution, and discard any product that appears discolored or contains particles.

Neoatricon is administered intravenously, typically as a continuous infusion. The infusion set should be primed with the solution, and the rate is adjusted according to the patient’s blood pressure, heart rate and overall hemodynamic response.

Serious risks include severe hypertension, myocardial ischemia, and life‑threatening arrhythmias such as ventricular tachycardia or fibrillation. Prompt monitoring of cardiovascular parameters is essential to detect and manage these events early.

Neoatricon is contraindicated in patients with uncorrected tachyarrhythmias, known hypersensitivity to dopamine, and should be used with extreme caution in individuals with pheochromocytoma or severe peripheral vascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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