Product image of Neoatricon (Dopamine Hydrochloride) supplied by GNH India

Neoatricon

Active Ingredient:
Dopamine Hydrochloride
Origin:
EU

Neoatricon (Dopamine Hydrochloride)

Dopamine Hydrochloride, the active ingredient in Neoatricon, is a catecholamine vasopressor presented as a sterile solution for intravenous use. It is employed to support cardiovascular function in patients with hypotension, shock, or reduced cardiac output.

GNH India supplies Neoatricon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Brepco Biopharma Limited

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Indications & Clinical Uses

Neoatricon (dopamine) acts on the cardiovascular and renal systems to restore perfusion and support cardiac output.

  • Hypotension/Shock: raises blood pressure and improves organ perfusion.
  • Acute Heart Failure: enhances myocardial contractility and cardiac output.
  • Renal Perfusion Impairment: increases renal blood flow to support kidney function.

How It Works

  • Dopamine Hydrochloride stimulates dopaminergic (D1) receptors at low doses, producing renal vasodilation; at intermediate doses it activates β1‑adrenergic receptors, increasing heart rate and contractility; at higher doses it engages α‑adrenergic receptors, causing vasoconstriction and raising systemic vascular resistance. The dose‑dependent receptor profile allows tailored hemodynamic support.

Side Effects

Common Side Effects

  • Tachycardia: increased heart rate.
  • Nausea: feeling of queasiness.
  • Vomiting: expulsion of stomach contents.
  • Headache: mild to moderate pain.
  • Anxiety: heightened nervousness.

Serious or Rare Side Effects

  • Arrhythmias: irregular heart rhythms.
  • Myocardial Ischemia: reduced heart muscle blood flow.
  • Tissue Necrosis at Infusion Site: local tissue death.
  • Severe Hypertension: dangerously high blood pressure.

Precautions & Warnings

Neoatricon requires careful monitoring and appropriate handling to ensure patient safety.

  • Monitor blood pressure: adjust infusion rate to maintain target levels.
  • Assess cardiac rhythm: watch for arrhythmias during therapy.
  • Evaluate renal function: dose may need adjustment in renal impairment.
  • Use caution in pheochromocytoma: risk of hypertensive crisis.
  • Avoid rapid bolus administration: may cause tachyarrhythmia.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Dopamine can interact with several medications, necessitating vigilance.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Beta‑blockers: may blunt inotropic response.
  • Alpha‑adrenergic antagonists: may reduce vasoconstrictive effect.

Moderate Interactions (Monitor Closely)

  • Diuretics: additive hypotensive effect.
  • Calcium channel blockers: may enhance vasodilation.

Frequently Asked Questions

Neoatricon is an intravenous formulation of dopamine hydrochloride used in hospital settings to treat acute hypotension, cardiogenic shock, and to improve renal perfusion. It supports blood pressure, enhances cardiac contractility, and can increase kidney blood flow when administered under physician supervision.

Dopamine acts on dopamine (D1), beta‑1, and alpha receptors in a dose‑dependent manner. Low doses cause renal vasodilation via D1 receptors, moderate doses stimulate beta‑1 receptors to raise heart rate and contractility, and high doses activate alpha receptors, producing vasoconstriction and raising systemic vascular resistance.

The dose of Neoatricon is individualized and determined by the prescribing clinician based on the patient’s hemodynamic status, weight, and therapeutic goals. Dosing is typically expressed in micrograms per kilogram per minute and adjusted according to continuous monitoring of blood pressure and cardiac output.

Limited clinical data exist for dopamine use in pregnancy and lactation. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Neoatricon, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and required import documentation.

Compared with norepinephrine, dopamine offers dose‑dependent renal vasodilation at low doses, which norepinephrine lacks. However, norepinephrine provides more predictable vasoconstriction with fewer tachyarrhythmic effects at equivalent pressor doses. Choice of agent depends on the clinical scenario and physician preference.

Neoatricon must be stored refrigerated between 2 °C and 8 °C, protected from light, and never frozen. Prior to use, inspect the vial for particulate matter and ensure the solution is at room temperature; do not shake vigorously, and use aseptic technique for dilution and administration.

Neoatricon is given by intravenous infusion. The sterile solution is diluted in compatible IV fluids and infused at a rate calculated in micrograms per kilogram per minute. Continuous hemodynamic monitoring is required to titrate the infusion to the desired blood pressure and cardiac output targets.

Serious risks include life‑threatening arrhythmias, myocardial ischemia, severe hypertension, and tissue necrosis at the infusion site. Immediate medical attention is required if patients develop chest pain, irregular heart rhythms, sudden blood pressure spikes, or signs of local tissue damage.

Neoatricon is contraindicated in patients with known hypersensitivity to dopamine or any formulation components, and should be used with extreme caution in individuals with pheochromocytoma, uncorrected tachyarrhythmias, or severe peripheral vascular disease where vasoconstriction could worsen tissue perfusion.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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