Product image of Neobacitracine (Bacitracin, Neomycin) supplied by GNH India

Neobacitracine

Active Ingredient:
Bacitracin, Neomycin
Origin:
EU

Neobacitracine (Bacitracin, Neomycin)

Bacitracin and Neomycin, the active ingredient in Neobacitracine, is an antibiotic presented as a topical ointment for skin use. It treats minor bacterial skin infections, cuts, abrasions and superficial burns in adults and children when applied locally.

GNH India supplies Neobacitracine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bepharbel Manufacturing S.A.

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Indications & Clinical Uses

Neobacitracine is a topical antibacterial that works on superficial bacterial skin conditions.

  • Minor skin infections: reduces bacterial load and promotes healing of localized infections.
  • Cuts, abrasions, and burns: prevents bacterial colonisation and supports recovery of superficial wounds.
  • Superficial bacterial skin infections: provides bactericidal activity against susceptible organisms on the skin surface.

How It Works

  • Bacitracin interferes with bacterial cell wall synthesis by inhibiting the dephosphorylation of bactoprenol, while neomycin binds to the 30S ribosomal subunit, disrupting protein synthesis. The combined actions result in a bactericidal effect against a broad range of Gram‑positive and some Gram‑negative skin pathogens.

Side Effects

Neobacitracine may cause local skin reactions.

Common Side Effects

  • Skin irritation or redness at the application site.
  • Itching or mild burning sensation.
  • Localized allergic dermatitis.

Serious or Rare Side Effects

  • Severe contact dermatitis with swelling.
  • Anaphylactic reaction requiring emergency care.
  • Systemic toxicity such as nephrotoxicity or ototoxicity, especially with extensive use.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Rare hypersensitivity reactions affecting multiple organ systems.

Precautions & Warnings

Use Neobacitracine only as directed and consider the following safety measures.

  • Avoid large surface area application: limit use to small affected areas to reduce systemic absorption.
  • Do not apply to deep puncture wounds or necrotic tissue.
  • Avoid use on mucous membranes, eyes, or genital skin.
  • Discontinue immediately if signs of allergic reaction appear.
  • Store at room temperature: keep in the original container, protect from moisture and direct heat.

Avoid Interactions

Neobacitracine can interact with other agents; monitor patients accordingly.

Major Interactions (Avoid)

  • Systemic aminoglycosides: increased risk of nephro‑ and ototoxicity.
  • Concurrent use of other topical antibiotics: heightened irritation.
  • Nephrotoxic drugs (e.g., vancomycin, loop diuretics): potential additive renal toxicity.
  • Ototoxic medications (e.g., loop diuretics, cisplatin): risk of hearing loss.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may mask signs of infection.
  • Antifungal agents: possible reduced efficacy of each product when used together.

Frequently Asked Questions

Neobacitracine is a topical antibacterial ointment used to treat minor skin infections, cuts, abrasions, burns and other superficial bacterial skin conditions. It helps prevent bacterial colonisation and supports the natural healing process when applied to the affected area.

Bacitracin blocks bacterial cell‑wall synthesis by inhibiting bactoprenol dephosphorylation, while neomycin binds to the 30S ribosomal subunit, disrupting protein synthesis. Together they produce a bactericidal effect that eliminates susceptible skin‑surface bacteria.

The dosage and frequency of Neobacitracine are determined by the prescribing healthcare professional based on the size and severity of the wound. Patients should follow the prescriber’s instructions and apply a thin layer to the clean, dry skin as directed.

Safety data for Neobacitracine in pregnancy and lactation are limited. Healthcare providers usually weigh the potential benefits against any unknown risks before prescribing. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their clinician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Neobacitracine combines bacitracin and neomycin, offering a broader spectrum of activity than single‑agent products such as bacitracin alone. It is comparable to other combination ointments like polymyxin‑bacitracin‑neomycin, but formulation differences may affect tolerability and risk of allergic reactions.

Neobacitracine should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme heat to maintain its stability and potency.

The ointment is applied topically to clean, dry skin. A thin layer is spread over the affected area, usually 1–3 times daily, or as directed by a healthcare professional. Hands should be washed before and after application.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and systemic toxicity (nephro‑ or ototoxicity) especially when used over large areas or for prolonged periods.

Individuals with a known hypersensitivity to bacitracin, neomycin, or any component of the formulation should avoid using Neobacitracine. It is also contraindicated on mucous membranes, deep puncture wounds, or extensive skin areas without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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