Product image of Neodidro (Calcifediol) supplied by GNH India

Neodidro

Active Ingredient:
Calcifediol
Origin:
EU

Neodidro (Calcifediol)

Calcifediol, the active ingredient in Neodidro, is a vitamin D analog presented as an oral formulation for oral use. It is used to treat vitamin D deficiency and support bone health in patients with related disorders.

GNH India supplies Neodidro as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bruno Farmaceutici

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Indications & Clinical Uses

Neodidro is a vitamin D analog indicated for conditions related to calcium metabolism and bone health.

  • Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels and improves calcium absorption.
  • Secondary hyperparathyroidism: helps reduce elevated parathyroid hormone concentrations associated with chronic kidney disease.
  • Support of bone health: contributes to normal bone remodeling and mineralization in at‑risk populations.

How It Works

  • Calcifediol is absorbed from the gastrointestinal tract and undergoes 25‑hydroxylation in the liver to form 25‑hydroxyvitamin D, which is then converted by renal 1‑α‑hydroxylase to calcitriol, the active hormone. Calcitriol binds to the vitamin D receptor (VDR) in target cells, enhancing transcription of genes that increase intestinal calcium and phosphate absorption and modulate bone turnover.

Side Effects

Calcifediol may be associated with a range of adverse reactions, most of which are dose‑related.

Common Side Effects

  • Hypercalcemia: elevated blood calcium levels.
  • Hyperphosphatemia: increased serum phosphate.
  • Nausea or gastrointestinal discomfort.
  • Headache.
  • Fatigue.

Serious or Rare Side Effects

  • Nephrolithiasis: kidney stone formation.
  • Cardiac arrhythmias due to electrolyte imbalance.
  • Severe hypercalcemia with renal impairment.
  • Allergic reactions such as rash or angioedema.

Precautions & Warnings

When prescribing Neodidro, clinicians should consider patient‑specific factors and monitor relevant parameters.

  • Renal function: assess kidney status before initiation and periodically thereafter.
  • Calcium levels: monitor serum calcium to avoid hypercalcemia.
  • Phosphate levels: check phosphate especially in patients with renal disease.
  • Concomitant vitamin D products: avoid duplicate therapy that may increase toxicity risk.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Calcifediol can interact with several medicines that affect calcium metabolism or vitamin D pathways.

Major Interactions (Avoid)

  • Thiazide diuretics: may exacerbate hypercalcemia.
  • Calcium supplements: increase risk of excessive calcium levels.
  • Vitamin D analogues (e.g., calcitriol): additive effect on calcium absorption.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenytoin, phenobarbital): may increase catabolism of vitamin D metabolites.
  • Glucocorticoids: can reduce vitamin D effectiveness.
  • Bisphosphonates: monitor bone turnover markers when used together.

Frequently Asked Questions

Neodidro contains calcifediol, a vitamin D analog used to correct vitamin D deficiency, manage secondary hyperparathyroidism, and support overall bone health in patients who require improved calcium and phosphate balance.

After oral absorption, calcifediol is converted in the liver to 25‑hydroxyvitamin D, which is then activated by the kidneys to calcitriol. Calcitriol binds to the vitamin D receptor, stimulating intestinal calcium and phosphate absorption and regulating bone remodeling processes.

The dosage of Neodidro is individualized. A qualified prescriber determines the appropriate amount based on the patient’s serum vitamin D level, renal function, and clinical condition. Patients should follow the prescribing information provided by their healthcare professional.

Safety data for calcifediol in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To request Neodidro, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Neodidro delivers calcifediol, which is one metabolic step closer to the active hormone calcitriol than cholecalciferol (vitamin D3). This can result in a more rapid and predictable rise in serum 25‑hydroxyvitamin D levels, especially in patients with impaired liver conversion.

Neodidro should be stored at ambient temperature, below 25 °C. Keep the product in its original container, protect it from moisture, heat and direct sunlight to maintain stability throughout its shelf life.

Neodidro is taken orally, usually with or without food, as directed by a healthcare professional. The exact administration schedule depends on the prescribed dose and the patient’s clinical response.

The most serious risks include hypercalcemia and hyperphosphatemia, which can lead to kidney stones, cardiac arrhythmias, or renal impairment. Prompt monitoring of serum calcium and phosphate levels is essential to mitigate these risks.

Neodidro is contraindicated in patients with known hypersensitivity to calcifediol or any excipients, and should be used with caution in individuals with severe renal impairment, uncontrolled hypercalcemia, or those already receiving high doses of calcium or vitamin D analogues.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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