Neodolpasse (Diclofenac Sodium, Orphenadrine Citrate)

Neodolpasse combines an NSAID and a centrally acting muscle relaxant to address pain, inflammation and muscle spasm associated with acute musculoskeletal conditions.

• Pain: provides analgesic relief in acute postoperative or traumatic conditions.
• Inflammation: reduces prostaglandin‑mediated inflammatory response in musculoskeletal injuries.
• Muscle spasm: relaxes skeletal muscle tone to improve mobility and comfort.
• Post‑operative recovery: facilitates early mobilization by controlling pain and spasm.

• Diclofenac sodium exerts its anti‑inflammatory effect by reversibly inhibiting cyclo‑oxygenase‑1 and cyclo‑oxygenase‑2 enzymes, thereby decreasing prostaglandin synthesis at sites of tissue injury. Orphenadrine citrate acts centrally as an anticholinergic agent that blocks muscarinic receptors and interferes with the central processing of muscle tone, producing skeletal muscle relaxation. This dual mechanism contributes to improved functional recovery after surgery.

Neodolpasse may be associated with a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

• Nausea
• Headache
• Injection site pain

Serious or Rare Side Effects

• Gastrointestinal bleeding
• Severe liver injury
• Anaphylactic reaction

When prescribing Neodolpasse, clinicians should consider several safety measures.

• Assess renal function: evaluate baseline creatinine clearance before initiating therapy.
• Monitor hepatic enzymes: check liver function tests periodically during treatment.
• Use caution in cardiovascular disease: NSAID component may increase blood pressure or risk of thrombotic events.
• Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
• Review concomitant anticoagulant therapy: increased bleeding risk may require dose adjustment.
• Store at ambient temperature: keep in original container, protect from moisture and light.

Neodolpasse can interact with other medicines, requiring careful assessment.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin, heparin): increased risk of bleeding.
• Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
• Monoamine oxidase inhibitors: potential hypertensive crisis due to anticholinergic load.

Moderate Interactions (Monitor Closely)

• Antihypertensives: NSAID may reduce their efficacy.
• Lithium: NSAID may raise lithium plasma concentrations.
• Diuretics: combined use may impair renal function.