Neofen Rapid (Ibuprofen Lysine)

• Ibuprofen lysine works as an NSAID to manage symptoms associated with pain, fever and inflammation.
• Pain: provides temporary relief of mild to moderate aches such as headache, dental or musculoskeletal pain.
• Fever: lowers elevated body temperature associated with common infections or inflammatory states.
• Inflammation: reduces swelling and discomfort in conditions like minor sprains, strains or soft‑tissue inflammation.

• Ibuprofen lysine exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitisation of nociceptors, lowers the hypothalamic set‑point for temperature, and curtails inflammatory mediators, resulting in analgesic, antipyretic, and anti‑inflammatory actions.

Ibuprofen lysine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

• Gastrointestinal discomfort or heartburn
• Nausea or mild vomiting
• Dizziness or headache
• Transient rash or itching

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration
• Severe allergic reaction (anaphylaxis, angioedema)
• Acute kidney injury or worsening of chronic renal disease
• Hepatotoxicity or elevated liver enzymes
• Blood dyscrasias such as thrombocytopenia

• Before using Neofen Rapid, consider the following safety measures.
• Assess gastrointestinal risk: avoid in patients with active ulcers or a history of serious GI bleeding.
• Monitor renal function: use with caution in individuals with impaired kidney function.
• Avoid concurrent anticoagulants: increased risk of bleeding when combined with warfarin, heparin or similar agents.
• Limit alcohol consumption: alcohol may exacerbate stomach irritation.
• Pregnancy and lactation: consult a healthcare professional before use.
• Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Ibuprofen lysine can interact with several medicines; awareness helps minimise risk.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): heightened bleeding tendency.
• Selective COX‑2 inhibitors (e.g., celecoxib): additive gastrointestinal toxicity.
• High‑dose aspirin: increased renal and gastric adverse effects.

Moderate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: possible reduction in antihypertensive efficacy.

• Diuretics: potential for reduced renal perfusion.
• Lithium: ibuprofen may raise serum lithium concentrations.