Neoflavon (Diosmin, Hesperidin)

Neoflavon, containing diosmin and hesperidin, is used in the management of venous disorders.

• Chronic venous insufficiency: improves venous return and reduces leg swelling and discomfort.
• Hemorrhoidal disease: alleviates bleeding, pain and swelling of hemorrhoidal tissue.
• Peripheral edema: helps decrease fluid accumulation in the lower limbs.

• Diosmin and hesperidin are flavonoids that reinforce capillary walls, decrease vascular permeability, and enhance venous tone. They inhibit prostaglandin synthesis, exert antioxidant activity, and improve microcirculatory flow, thereby reducing stasis and inflammation in the venous system.

Neoflavon may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

• Gastrointestinal discomfort: mild abdominal pain or upset stomach.
• Nausea: occasional feeling of queasiness.
• Headache: transient mild to moderate headache.
• Dizziness: brief episodes of light‑headedness.
• Skin rash: mild erythema or itching.
• Diarrhoea: loose stools in some patients.

Serious or Rare Side Effects

• Anaphylaxis: severe allergic reaction with breathing difficulty.
• Hepatic dysfunction: elevated liver enzymes or jaundice.
• Thrombocytopenia: marked reduction in platelet count.
• Severe hypotension: sudden drop in blood pressure.
• Vision changes: blurred vision or visual disturbances.
• Blood clotting disorders: abnormal coagulation events.

Before initiating therapy with Neoflavon, consider the following safety measures.

• Assess renal function: adjust use in patients with severe renal impairment.
• Monitor for gastrointestinal bleeding: exercise caution in those with a history of ulcers.
• Evaluate hypersensitivity: discontinue if allergic reactions occur.
• Use caution in pregnancy: only if potential benefit outweighs risk.
• Avoid in children unless specifically prescribed by a qualified clinician.
• Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Neoflavon can interact with several medicines; awareness of these interactions helps minimise risk.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Antiplatelet agents (e.g., aspirin, clopidogrel): additive antithrombotic effect.
• Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise plasma levels of flavonoids.

Moderate Interactions (Monitor Closely)

• Non‑steroidal anti‑inflammatory drugs (NSAIDs): heightened gastrointestinal irritation.
• Diuretics: possible electrolyte imbalance.
• Statins: potential increase in myopathy risk.