Product image of Neohepatect (Human Hepatitis B Immunoglobulin) supplied by GNH India

Neohepatect

Active Ingredient:
Human Hepatitis B Immunoglobulin
Origin:
EU

Neohepatect (Human Hepatitis B Immunoglobulin)

Human Hepatitis B Immunoglobulin, the active ingredient in Neohepatect, is an Immunoglobulin (HBIG) presented as an injectable solution for intravenous use. It provides passive immunity to prevent hepatitis B infection after exposure and is used for post‑exposure prophylaxis and transplant‑related prevention.
GNH India supplies Neohepatect as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

Manufacturer / TM Owner

Biotest Pharma Gmbh

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Indications & Clinical Uses

Neohepatect, a hepatitis B immunoglobulin, acts on the viral infection pathway to provide passive immunity.

  • Post‑exposure prophylaxis after known or suspected hepatitis B exposure: prevents establishment of infection.
  • Prevention of hepatitis B transmission to newborns of HBsAg‑positive mothers: reduces risk of vertical transmission.
  • Prevention of hepatitis B recurrence after liver transplantation: maintains protective anti‑HBs titres.

How It Works

  • Human Hepatitis B Immunoglobulin supplies exogenous anti‑HBs antibodies that bind to hepatitis B surface antigen, neutralizing the virus and blocking its entry into hepatocytes. This passive immunization rapidly raises anti‑HBs titres, providing immediate protection while the host’s active immune response develops.

Side Effects

Neohepatect may cause adverse reactions following intravenous administration.

Common Side Effects

  • Fever: transient elevation of body temperature after infusion.
  • Chills: shaking sensations often accompanying fever.
  • Headache: mild to moderate discomfort.
  • Injection site reaction: redness, swelling or pain at the infusion site.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Serum sickness-like reaction: fever, rash, arthralgia occurring days after exposure.
  • Renal dysfunction: impaired kidney function observed in rare cases.

Precautions & Warnings

Before using Neohepatect, consider the following precautions.

  • Screen for HBV immunity: assess anti‑HBs status prior to administration.
  • Monitor for allergic reactions: observe patient during and after infusion.
  • Use caution in immunocompromised patients: response may be altered.
  • Avoid concurrent live vaccines: may interfere with immune response.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Neohepatect may interact with other agents as follows.

Major Interactions (Avoid)

  • Concurrent administration of blood products containing anti‑HBs: may reduce efficacy.
  • Use with other hepatitis B immunoglobulin products: risk of antibody overload.

Moderate Interactions (Monitor Closely)

  • Hepatitis B vaccine: may interfere with antibody titres.
  • Immunosuppressants: may affect the protective response.
  • Nephrotoxic drugs: monitor renal function during combined therapy.

Frequently Asked Questions

Neohepatect is a human hepatitis B immunoglobulin administered intravenously to provide passive immunity against hepatitis B virus. It is indicated for post‑exposure prophylaxis after potential exposure, for preventing mother‑to‑child transmission, and for maintaining protection in liver transplant recipients.

The immunoglobulin contains high‑titer anti‑HBs antibodies that bind to hepatitis B surface antigen, neutralizing the virus and blocking its entry into liver cells. This rapid increase in circulating antibodies offers immediate protection while the patient’s own immune system develops a longer‑term response.

The dosage of Neohepatect is determined by the prescribing clinician based on the patient’s weight, exposure risk, and clinical context. The prescriber sets the exact amount and infusion rate according to established guidelines and individual patient needs.

Safety data for Neohepatect in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To request Neohepatect, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling) and import documentation.

Neohepatect provides passive immunity through high‑titer anti‑HBs antibodies, offering immediate protection, whereas hepatitis B vaccines stimulate active immunity over weeks. Compared with other HBIG products, Neohepatect is sourced from EU‑approved plasma and meets GMP standards, delivering comparable efficacy and safety profiles.

Neohepatect must be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Before use, allow the product to reach room temperature if required, and inspect for particulate matter or discoloration.

Neohepatect is given as an intravenous infusion by a qualified healthcare professional. The infusion rate and volume are set according to the prescribed dose, and the patient should be monitored for any immediate adverse reactions during and after the administration.

The most serious risks include severe allergic reactions such as anaphylaxis, serum sickness‑like reactions, and rare cases of renal dysfunction. Prompt medical attention is required if symptoms such as difficulty breathing, rash, fever, or reduced urine output occur.

Neohepatect should not be used in individuals with a known hypersensitivity to human immunoglobulin preparations or any of its excipients. Caution is advised in patients with severe renal impairment, and it is contraindicated in those with a history of severe anaphylactic reactions to immunoglobulins.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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