Product image of Neoparin (Enoxaparin Sodium) supplied by GNH India

Neoparin

Active Ingredient:
Enoxaparin Sodium
Origin:
EU

Neoparin (Enoxaparin Sodium)

Enoxaparin Sodium, the active ingredient in Neoparin, is a low molecular weight heparin presented as a sterile injectable solution for subcutaneous, intravenous, or haemodialysis use. It is employed to prevent and treat thromboembolic disorders in adult patients at risk of clot formation.

GNH India supplies Neoparin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide, providing regulatory‑approved batches to healthcare institutions across multiple regions.

Manufacturer / TM Owner

Sciencepharma Spółka Z Ograniczoną Odpowiedzialnością

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Indications & Clinical Uses

Neoparin, a low molecular weight heparin, is used in clinical settings to manage and prevent thrombotic conditions.

  • Prevention of venous thromboembolism: reduces the risk of clot formation in patients undergoing surgery or prolonged immobilisation.
  • Treatment of deep vein thrombosis: facilitates clot resolution and prevents propagation in diagnosed DVT cases.
  • Prevention of clotting during haemodialysis: maintains circuit patency by inhibiting coagulation during dialysis sessions.

How It Works

  • Enoxaparin Sodium enhances the activity of antithrombin III, leading to selective inhibition of factor Xa and, to a lesser extent, factor IIa (thrombin). This results in reduced generation of thrombin and fibrin, thereby limiting clot formation while preserving a degree of normal haemostatic function.

Side Effects

Adverse reactions to Neoparin may vary in frequency and severity.

Common Side Effects

  • Injection site bruising or pain.
  • Mild bleeding such as epistaxis or gum bleeding.
  • Nausea or abdominal discomfort.
  • Headache.
  • Transient elevation of liver enzymes.

Serious or Rare Side Effects

  • Major hemorrhage (intracranial, gastrointestinal, or surgical site).
  • Heparin‑induced thrombocytopenia (HIT).
  • Spinal or epidural hematoma.
  • Severe allergic reactions (anaphylaxis, urticaria).
  • Adrenal cortical hemorrhage.

Precautions & Warnings

Before initiating Neoparin, clinicians should evaluate patient‑specific risk factors and monitor for complications.

  • Renal impairment: adjust dose or monitor anti‑Xa activity.
  • History of bleeding: assess risk and consider alternative therapy.
  • Concurrent anticoagulants: avoid additive bleeding risk.
  • Pregnancy: use only when benefit outweighs potential fetal risk.
  • Surgery or invasive procedures: discontinue according to protocol before the procedure.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Neoparin may interact with other medicines that affect haemostasis or renal clearance.

Major Interactions (Avoid)

  • Warfarin: increased risk of severe bleeding.
  • Dual antiplatelet therapy (aspirin plus clopidogrel): additive haemorrhagic effect.
  • Thrombolytic agents (e.g., alteplase): potentiates anticoagulation.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase gastrointestinal bleeding.
  • Renally cleared drugs (e.g., aminoglycosides): monitor anti‑Xa activity.
  • Hormone replacement therapy: may elevate clot risk.

Frequently Asked Questions

Neoparin is an injectable anticoagulant used to prevent venous thromboembolism, treat established deep vein thrombosis, and maintain circuit patency during haemodialysis by inhibiting clot formation.

Enoxaparin Sodium binds to antithrombin III, accelerating its inhibition of factor Xa and, to a lesser extent, factor IIa (thrombin). This reduces thrombin generation and fibrin formation, thereby limiting clot development while preserving essential haemostatic activity.

The dose of Neoparin is individualized by the prescribing clinician based on the specific indication, patient weight, renal function, and clinical setting. Exact dosing regimens are determined at the point of care.

Safety data for Enoxaparin in pregnancy are limited; it may be used only when the potential maternal benefit justifies any possible risk to the fetus. Breastfeeding considerations should be discussed with a healthcare professional.

To order Neoparin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and import documentation.

Neoparin (enoxaparin) is a low molecular weight heparin offering more predictable pharmacokinetics, once‑ or twice‑daily dosing, and a lower risk of heparin‑induced thrombocytopenia compared with unfractionated heparin, which often requires continuous infusion and frequent laboratory monitoring.

Neoparin should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Once removed from refrigeration, it may be kept at controlled room temperature for a limited period as indicated on the label.

Neoparin is administered by subcutaneous injection, intravenous infusion, or added to the extracorporeal circuit during haemodialysis, according to the clinical protocol established by the treating physician.

The most serious risks include major bleeding events, heparin‑induced thrombocytopenia (HIT), spinal or epidural hematoma, and severe allergic reactions. Prompt medical evaluation is required if any of these occur.

Neoparin is contraindicated in patients with active major bleeding, known hypersensitivity to enoxaparin or other LMWHs, and those with a history of HIT. Caution is also advised for individuals with severe renal impairment or uncontrolled hypertension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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