Product image of Neophyr (Nitric Oxide) supplied by GNH India

Neophyr

Active Ingredient:
Nitric Oxide
Origin:
EU

Neophyr (Nitric Oxide)

Nitric Oxide, the active ingredient in Neophyr, is a nitric oxide donor presented as a medical gas for inhalation use. It delivers selective pulmonary vasodilation, helping to lower pulmonary arterial pressure in patients with pulmonary hypertension.

GNH India supplies Neophyr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides reliable sourcing for clinical and institutional customers across multiple regions. Our distribution network ensures timely delivery and regulatory support for each order.

Manufacturer / TM Owner

Sol Spa

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Neophyr is used to manage conditions involving elevated pulmonary vascular resistance.
  • Pulmonary arterial hypertension: lowers pulmonary arterial pressure, enhancing oxygen delivery and exercise tolerance.
  • Chronic thromboembolic pulmonary hypertension: promotes selective vasodilation of pulmonary vessels, aiding symptom relief.
  • Right ventricular overload due to pulmonary hypertension: decreases afterload on the right heart, supporting cardiac function.

How It Works

  • Nitric Oxide released from Neophyr activates soluble guanylate cyclase in pulmonary smooth muscle cells, increasing cyclic GMP levels. Elevated cGMP leads to relaxation of vascular smooth muscle, producing selective vasodilation of the pulmonary circulation without significant systemic effects, thereby reducing pulmonary arterial pressure and improving gas exchange.

Side Effects

Adverse reactions may occur with inhaled nitric oxide therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness or light‑headedness.
  • Flushing of the skin.
  • Nausea or mild gastrointestinal upset.
  • Cough or throat irritation.
  • Transient systemic hypotension.

Serious or Rare Side Effects

  • Methemoglobinemia: elevated methemoglobin levels causing reduced oxygen delivery.
  • Rebound pulmonary hypertension upon abrupt discontinuation.
  • Severe systemic hypotension leading to syncope.
  • Bleeding complications in patients on anticoagulants.
  • Pulmonary edema in susceptible individuals.

Precautions & Warnings

  • Neophyr requires careful clinical monitoring and adherence to safety guidelines.
  • Indication verification: confirm diagnosis of pulmonary hypertension before initiation.
  • Monitoring: regularly assess pulmonary artery pressure, oxygenation, and methemoglobin levels.
  • Contraindications: avoid use in patients with severe left ventricular dysfunction.
  • Pregnancy: consider only if potential benefits outweigh risks.
  • Drug interactions: be aware of additive vasodilatory effects with phosphodiesterase inhibitors.
  • Store at ambient temperature (below 30°C): keep cylinder in original packaging, protect from direct sunlight and extreme heat.

Avoid Interactions

Nitric Oxide therapy may interact with other agents affecting vascular tone.

Major Interactions (Avoid)

  • Sildenafil or other phosphodiesterase‑5 inhibitors: additive vasodilation causing profound hypotension.
  • Concurrent inhaled vasodilators (e.g., inhaled prostacyclin): risk of excessive pulmonary vasodilation.
  • Systemic nitroglycerin: synergistic hypotensive effect.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin): increased bleeding risk due to vasodilatory changes.
  • Beta‑blockers: may blunt hemodynamic response to therapy.
  • Inhaled corticosteroids: generally safe, but monitor for respiratory irritation.

Frequently Asked Questions

Neophyr is an inhaled medical gas containing nitric oxide, used primarily to treat pulmonary hypertension and related conditions by providing selective vasodilation of the pulmonary arteries, which helps lower pulmonary arterial pressure and improve oxygenation.

Nitric oxide released from Neophyr activates soluble guanylate cyclase in the smooth muscle of pulmonary vessels, raising cyclic GMP levels. This biochemical cascade causes relaxation of the vascular smooth muscle, resulting in targeted dilation of the pulmonary circulation without major systemic effects.

The prescribed dose of Neophyr is determined by the treating physician based on the patient’s clinical status, severity of pulmonary hypertension, and response to therapy. Dosage adjustments are made according to monitoring of pulmonary pressures and methemoglobin levels.

Safety data for Neophyr in pregnancy and lactation are limited. It should only be used when the potential therapeutic benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To order Neophyr, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Neophyr delivers nitric oxide directly to the lungs, offering rapid and selective pulmonary vasodilation. Compared with systemic agents such as oral phosphodiesterase‑5 inhibitors, it provides immediate effect with minimal systemic hypotension, but requires inhalation equipment and careful monitoring.

Neophyr should be stored at ambient temperature, preferably below 30 °C, in its original cylinder packaging. Protect the cylinder from direct sunlight, extreme heat, and physical damage. Follow local regulations for handling pressurized medical gases.

Neophyr is administered via inhalation using a calibrated delivery system that mixes the gas with the patient’s breathing circuit. The healthcare provider sets the flow rate and concentration according to the prescribed regimen and continuously monitors the patient’s respiratory and hemodynamic parameters.

Serious risks include methemoglobinemia, which can impair oxygen delivery, and rebound pulmonary hypertension if therapy is stopped abruptly. Severe systemic hypotension and bleeding complications in patients on anticoagulants are also important safety considerations.

Neophyr should be avoided in patients with severe left‑ventricular dysfunction, known hypersensitivity to nitric oxide, or those who cannot be monitored for methemoglobin levels. Caution is also advised for individuals on concurrent potent vasodilators or with uncontrolled systemic hypotension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Nitric Oxide

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT