Product image of Neorelium (Diazepam) supplied by GNH India

Neorelium

Active Ingredient:
Diazepam
Origin:
EU

Neorelium (Diazepam)

Diazepam, the active ingredient in Neorelium, is a benzodiazepine presented as an oral dosage form for oral use. It is prescribed for anxiety disorders, seizure control, muscle spasm relief, and management of alcohol withdrawal syndrome in adult patients.

GNH India supplies Neorelium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tarchomińskie Zakłady Farmaceutyczne "polfa" Spółka Akcyjna

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Indications & Clinical Uses

Diazepam acts on the central nervous system to modulate GABA‑mediated inhibition, providing therapeutic benefit across several conditions.

  • Anxiety disorders: reduces excessive anxiety and associated physical symptoms.
  • Seizure disorders: controls various types of seizures and status epilepticus.
  • Muscle spasm: relaxes skeletal muscle tone in acute spastic conditions.
  • Alcohol withdrawal syndrome: alleviates agitation, tremor and risk of seizures during detoxification.

How It Works

  • Diazepam binds to a specific site on the GABA‑A receptor complex, acting as a positive allosteric modulator. This enhances the frequency of chloride channel opening in response to GABA, increasing neuronal hyperpolarisation and producing overall inhibitory effects on central nervous system activity.

Side Effects

Diazepam may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dizziness: light‑headed sensation, especially when standing quickly.
  • Impaired coordination: reduced motor control and balance.
  • Memory impairment: difficulty forming new memories.
  • Blurred vision: temporary visual disturbances.
  • Fatigue: general lack of energy.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing, potentially life‑threatening.
  • Severe hypotension: marked drop in blood pressure.
  • Paradoxical reactions: agitation, aggression or hostility.
  • Dependence and withdrawal syndrome: physical and psychological reliance with withdrawal on abrupt cessation.
  • Stevens‑Johnson syndrome: rare severe skin reaction.
  • Depression of central nervous system: profound sedation or coma.

Precautions & Warnings

When prescribing or dispensing diazepam, several safety considerations are essential.

  • Assess renal and hepatic function: adjust therapy if impairment is present.
  • Avoid abrupt discontinuation: taper the dose under medical supervision to prevent withdrawal.
  • Use caution in elderly patients: increased sensitivity to sedation and falls.
  • Avoid concomitant CNS depressants: risk of additive sedation and respiratory depression.
  • Pregnancy and lactation: discuss potential risks with a qualified healthcare professional.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Diazepam can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Opioids: additive respiratory depression and profound sedation.
  • Alcohol: enhanced central nervous system depression and risk of overdose.
  • Barbiturates: synergistic CNS depression leading to profound sedation.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may increase diazepam plasma concentrations.
  • CYP3A4 inducers (e.g., rifampin): may reduce diazepam effectiveness.

Frequently Asked Questions

Neorelium contains diazepam, a benzodiazepine indicated for the short‑term relief of anxiety disorders, control of various seizure types, management of acute muscle spasm, and treatment of alcohol withdrawal syndrome. It is prescribed by qualified healthcare professionals based on individual patient needs.

Diazepam binds to the benzodiazepine site on the GABA‑A receptor, enhancing the inhibitory effect of the neurotransmitter GABA. This increases chloride ion influx, hyperpolarising neurons and reducing excitability, which produces anxiolytic, anticonvulsant, muscle‑relaxant and sedative effects.

The appropriate dose of Neorelium is determined by the prescribing clinician based on the specific indication, patient age, weight, liver function and concomitant therapies. Dosage regimens are individualized and should follow the prescriber’s written instructions.

Safety data for diazepam in pregnancy and lactation are limited. It is classified as a potential risk to the fetus and may pass into breast milk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential benefits and risks with their healthcare provider before using Neorelium.

To place an order, submit an enquiry on the Neorelium product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Neorelium (diazepam) has a relatively long half‑life compared with agents such as lorazepam or alprazolam, providing prolonged therapeutic coverage but also a higher potential for accumulation. Its potency, onset of action and side‑effect profile are comparable to other benzodiazepines, making choice dependent on clinical context, duration of therapy and patient tolerance.

Neorelium should be stored at ambient temperature, below 25 °C, in its original packaging to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged or the tablet appears discoloured.

Neorelium is intended for oral administration. Swallow the tablet whole with a glass of water; do not crush, chew or split unless specifically instructed by a healthcare professional. The exact dosing schedule is set by the prescriber.

Serious risks include respiratory depression, severe hypotension, paradoxical reactions such as agitation or aggression, dependence with withdrawal syndrome on abrupt discontinuation, and rare severe skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience difficulty breathing, extreme drowsiness, rash or any unexpected behavioural changes.

Neorelium is contraindicated in individuals with known hypersensitivity to diazepam or other benzodiazepines, those with acute narrow‑angle glaucoma, and patients with severe respiratory insufficiency. Caution is also advised for patients with a history of substance

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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