Product image of Neotigason (Acitretin) supplied by GNH India

Neotigason

Active Ingredient:
Acitretin
Origin:
EU

Neotigason (Acitretin)

Acitretin, the active ingredient in Neotigason, is a retinoid presented as an oral tablet for systemic use. It is indicated for severe psoriasis and other disorders of keratinization, helping to normalize skin cell growth in adult patients.

GNH India supplies Neotigason as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Neotigason (acitretin) is a systemic retinoid used to treat disorders of keratinization.

  • Severe psoriasis: reduces plaque formation, scaling and erythema.
  • Ichthyosis: improves skin barrier function and decreases scaling.
  • Other keratinization disorders: normalizes keratinocyte differentiation and limits hyperproliferation.

How It Works

  • Acitretin is a synthetic retinoid that binds to nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in keratinocytes. This interaction modulates gene transcription, leading to reduced epidermal cell proliferation, promotion of normal differentiation, and decreased inflammation in the skin.

Side Effects

Acitretin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dry skin: increased transepidermal water loss.
  • Cheilitis: inflammation of the lips.
  • Hair loss: temporary alopecia.
  • Elevated liver enzymes: mild hepatic transaminase rise.
  • Hyperlipidemia: raised cholesterol or triglycerides.
  • Headache: mild to moderate intensity.

Serious or Rare Side Effects

  • Severe hepatic injury: potential liver failure.
  • Pancreatitis: inflammation of the pancreas.
  • Depression or suicidal ideation: mood changes requiring monitoring.
  • Severe hypertriglyceridemia: risk of pancreatitis.
  • Bone abnormalities: premature epiphyseal closure in long‑term use.
  • Teratogenicity: birth defects if exposure occurs during pregnancy.

Precautions & Warnings

Neotigason requires careful monitoring and specific safety measures.

  • Pregnancy: contraindicated; teratogenic (Category X).
  • Women of childbearing potential: use effective contraception during treatment and for at least 3 years after discontinuation.
  • Liver function: monitor hepatic enzymes before and during therapy.
  • Lipid profile: assess triglycerides and cholesterol regularly.
  • Skeletal health: evaluate for bone changes during prolonged use.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Acitretin interacts with several medicines; some combinations should be avoided while others need close observation.

Major Interactions (Avoid)

  • Tetracyclines: increased risk of intracranial hypertension.
  • Vitamin A supplements: additive hypervitaminosis A.
  • Systemic steroids: reduced therapeutic efficacy.
  • Oral contraceptives: decreased contraceptive effectiveness.
  • Antifungal agents (e.g., ketoconazole): elevated acitretin plasma levels.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of INR.
  • Phenytoin: hepatic enzyme induction may lower acitretin levels.
  • Statins: heightened risk of myopathy.
  • Beta‑blockers: potential skin reaction augmentation.
  • Methotrexate: combined hepatotoxicity risk.

Frequently Asked Questions

Neotigason contains acitretin, a systemic retinoid prescribed for severe plaque psoriasis and other keratinization disorders such as ichthyosis. It works by normalizing skin cell growth, reducing scaling, and improving overall skin appearance in adult patients.

Acitretin binds to nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR) in skin cells. This binding alters gene expression, leading to decreased keratinocyte proliferation, promotion of normal differentiation, and reduced inflammatory activity in the epidermis.

The dose of Neotigason is individualized by the prescribing clinician based on disease severity, patient weight, and laboratory parameters. Physicians typically start with a low dose and adjust gradually, always following local prescribing guidelines.

Neotigason is classified as pregnancy category X because it is highly teratogenic. It must not be used by pregnant women or women who may become pregnant. Breastfeeding is also discouraged, as the drug can be excreted in milk and affect the infant.

To request Neotigason, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Acitretin is a non‑biologic oral retinoid, offering an alternative to methotrexate, cyclosporine or biologic agents. Unlike biologics, it does not target immune pathways, but it is effective for patients with extensive plaque psoriasis who prefer an oral option. Its safety profile differs, with notable teratogenic risk and lipid changes, whereas biologics carry infection‑related concerns.

Neotigason should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight. Do not store in bathrooms or near heat sources, and keep out of reach of children.

Neotigason is taken orally, usually with a full glass of water. It can be taken with or without food, but consistent administration with respect to meals helps maintain stable blood levels. Swallow the tablet whole; do not crush or chew.

The most serious risks include teratogenicity, severe liver injury, marked hypertriglyceridemia that can lead to pancreatitis, and rare psychiatric effects such as depression or suicidal thoughts. Patients should be monitored regularly for liver function, lipid levels and mental health status.

Neotigason is contraindicated in pregnant women, women planning pregnancy, and those who cannot ensure effective contraception for the required period. It should also be avoided in patients with severe hepatic impairment, uncontrolled hyperlipidaemia, or known hypersensitivity to acitretin or other retinoids.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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