Product image of Neotigason (Acitretin) supplied by GNH India

Neotigason

Active Ingredient:
Acitretin
Origin:
EU

Neotigason (Acitretin)

Acitretin, the active ingredient in Neotigason, is a retinoid presented as an oral tablet for oral use. It is indicated for the treatment of severe psoriasis in adult patients, helping to normalize epidermal growth and reduce plaque formation. It is prescribed when topical therapies are insufficient and is part of systemic management strategies for chronic plaque psoriasis.

GNH India supplies Neotigason as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Acitretin is a systemic retinoid used in the management of severe psoriasis, a chronic inflammatory skin disorder.

  • Severe plaque psoriasis: reduces plaque thickness, scaling and erythema.
  • Generalized pustular psoriasis: helps control pustule formation and inflammation.
  • Disorders of keratinization (e.g., ichthyosis): normalizes epidermal differentiation in conditions such as ichthyosis.

How It Works

  • Acitretin binds to nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in keratinocytes, modulating gene transcription that controls cell differentiation and proliferation. This interaction restores normal epidermal growth, reduces hyperkeratinisation, and diminishes inflammatory cytokine production, leading to improvement of psoriatic lesions.

Side Effects

Acitretin may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Dry skin: increased epidermal dryness and scaling.
  • Cheilitis: inflammation and cracking of the lips.
  • Hair loss: temporary thinning of scalp hair.
  • Headache: mild to moderate cephalic discomfort.
  • Elevated liver enzymes: mild transaminase rise.
  • Hyperlipidaemia: increase in serum cholesterol and triglycerides.

Serious or Rare Side Effects

  • Teratogenicity: severe fetal malformations if exposure occurs during pregnancy.
  • Severe hepatic injury: rare cases of liver failure.
  • Pancreatitis: inflammation of the pancreas.
  • Depression or mood changes: rare psychiatric effects.
  • Pseudotumor cerebri: increased intracranial pressure.
  • Severe hypertriglyceridaemia: risk of pancreatitis.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Pregnancy contraindication: avoid use in pregnant women and women of childbearing potential.
  • Contraception requirement: effective birth control must be used during treatment and for at least three years after discontinuation.
  • Liver function monitoring: assess baseline and periodic hepatic enzymes.
  • Lipid profile monitoring: check serum lipids before and during therapy.
  • Alcohol avoidance: limit alcohol to reduce hepatic risk.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Acitretin can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Tetracyclines: increased risk of intracranial hypertension.
  • Vitamin A supplements: additive retinoid toxicity.
  • Oral contraceptives: reduced efficacy, increasing teratogenic risk.

Moderate Interactions (Monitor Closely)

  • Statins: potential for altered lipid levels.
  • Antifungal agents (e.g., ketoconazole): may affect hepatic metabolism of acitretin.

Frequently Asked Questions

Neotigason contains acitretin, a retinoid indicated for the systemic treatment of severe psoriasis in adults. It helps to normalize skin cell growth, reducing plaque thickness, scaling, and redness associated with chronic plaque and pustular forms of the disease.

Acitretin binds to nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in skin cells, altering gene expression that controls keratinocyte differentiation and proliferation. This modulation restores normal epidermal turnover and reduces inflammatory signaling, leading to improvement of psoriatic lesions.

The dosage of Neotigason is individualized by the prescribing physician based on disease severity, patient weight, and tolerability. The prescriber determines the appropriate starting dose and any subsequent adjustments, following clinical guidelines and monitoring requirements.

Neotigason is classified as pregnancy category X because it is highly teratogenic. It must not be used by pregnant women or women who could become pregnant. Breastfeeding is also contraindicated, as the drug can be excreted in milk and affect the infant.

To place an order, submit an enquiry on the Neotigason product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with biologic agents, acitretin (Neotigason) is an oral small‑molecule retinoid that does not target specific immune pathways. It is less immunosuppressive but carries a higher risk of teratogenicity and lipid abnormalities. It may be preferred when injectable biologics are unsuitable or when a non‑biologic oral option is desired.

Neotigason should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Neotigason is taken orally, usually with a full glass of water. The tablet is swallowed whole and should be taken as directed by the prescriber, often with meals to reduce gastrointestinal discomfort.

The most serious risks include teratogenicity, which can cause severe fetal malformations, and potential liver toxicity. Patients should be monitored for elevated liver enzymes, severe hyperlipidaemia, and rare events such as pancreatitis or pseudotumor cerebri.

Neotigason is contraindicated in pregnant women, women of childbearing potential who are not using effective contraception, patients with severe liver disease, uncontrolled hyperlipidaemia, and individuals with known hypersensitivity to acitretin or other retinoids.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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