Product image of Neotigason (Acitretin) supplied by GNH India

Neotigason

Active Ingredient:
Acitretin
Origin:
EU

Neotigason (Acitretin)

Acitretin, the active ingredient in Neotigason, is a retinoid presented as an oral tablet for systemic use. It is indicated for the treatment of severe psoriasis and other disorders of keratinization in adult patients.
GNH India supplies Neotigason as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Neotigason is a retinoid used in dermatology to normalize skin cell growth and differentiation.

  • Severe psoriasis: reduces plaque formation and improves skin appearance.
  • Psoriatic keratoderma: softens thickened skin on palms and soles.
  • Disorders of keratinization: helps normalize abnormal keratinocyte proliferation.

How It Works

  • Acitretin binds to nuclear retinoic acid receptors (RAR-α, RAR-β, RAR-γ), modulating gene transcription that controls keratinocyte differentiation and proliferation. This leads to normalization of epidermal growth, reduced inflammation, and decreased scaling in affected skin.

Side Effects

Acitretin may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Dry skin and mucous membranes: dryness of lips, eyes, and nasal passages.
  • Elevated liver enzymes: mild, transient increases in hepatic transaminases.
  • Hyperlipidaemia: rise in triglycerides and cholesterol levels.
  • Hair loss: temporary alopecia or thinning.
  • Headache: mild to moderate intensity.
  • Gastrointestinal discomfort: nausea or abdominal pain.

Serious or Rare Side Effects

  • Severe hepatic dysfunction: jaundice, hepatitis, or liver failure.
  • Pancreatitis: acute inflammation of the pancreas.
  • Pseudotumor cerebri: increased intracranial pressure causing visual disturbances.
  • Severe hypertriglyceridaemia: risk of pancreatitis.
  • Depression or mood changes: rare but clinically significant.
  • Skeletal toxicity: premature epiphyseal closure in children or bone demineralisation.

Precautions & Warnings

Acitretin requires careful monitoring due to its potent pharmacologic profile.

  • Pregnancy: contraindicated; teratogenic risk persists up to 3 years after discontinuation.
  • Liver function: assess baseline enzymes and monitor periodically.
  • Lipid profile: check fasting triglycerides and cholesterol before and during therapy.
  • Alcohol use: avoid excessive intake as it may increase hepatotoxicity.
  • Concomitant vitamin A: avoid additional retinoids to prevent cumulative toxicity.
  • Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Acitretin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Tetracyclines: increased risk of intracranial hypertension.
  • Vitamin A supplements or other retinoids: additive teratogenic and toxicity risk.
  • Cholestyramine or colestipol: reduces acitretin absorption, lowering effectiveness.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced hormonal efficacy, necessitating alternative contraception.
  • Warfarin: potential alteration of INR, requiring closer coagulation monitoring.
  • Statins: may exacerbate lipid abnormalities; monitor lipid levels.

Frequently Asked Questions

Neotigason contains acitretin, a retinoid prescribed for severe psoriasis, psoriatic keratoderma, and other disorders of keratinization. It works by normalising skin cell growth, helping to reduce plaques, scaling, and thickened skin in adult patients.

Acitretin binds to nuclear retinoic acid receptors (RARs) in skin cells, altering gene expression that controls keratinocyte differentiation and proliferation. This modulation reduces abnormal skin cell turnover and inflammation, leading to clearer skin in conditions like psoriasis.

The dose of Neotigason is determined individually by the prescribing physician based on disease severity, patient weight, and laboratory results. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Neotigason is classified as pregnancy category X because it is highly teratogenic. It must not be used by pregnant women or women who may become pregnant, and effective contraception is required during treatment and for up to three years after stopping. Breastfeeding is also contraindicated.

To order Neotigason, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Neotigason (acitretin) is an oral retinoid, differing from biologics and topical agents. It is especially useful for severe plaque psoriasis and keratinization disorders when systemic therapy is needed, but it requires careful monitoring for liver, lipid, and teratogenic risks, unlike many biologics that target immune pathways.

Neotigason tablets should be stored below 25 °C in their original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use if the packaging is damaged.

Neotigason is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not crushed or chewed. Dosing schedules vary, and patients should follow the prescriber’s specific instructions regarding timing and food intake.

The most serious risks include severe birth defects if taken during pregnancy, significant liver toxicity, marked hyperlipidaemia, pancreatitis, and rare cases of intracranial hypertension (pseudotumor cerebri). Patients should be monitored regularly for these complications.

Neotigason should not be used by pregnant or nursing women, individuals planning pregnancy within three years of treatment, patients with severe liver disease, uncontrolled hyperlipidaemia, or those taking contraindicated medications such as other retinoids or tetracyclines without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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