Product image of Neotigason (Acitretin) supplied by GNH India

Neotigason

Active Ingredient:
Acitretin
Origin:
EU

Neotigason (Acitretin)

Acitretin, the active ingredient in Neotigason, is a retinoid presented as an oral tablet for systemic use. It is prescribed for severe forms of psoriasis and other disorders of keratinization in adult patients.

GNH India supplies Neotigason as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Neotigason is a retinoid that acts on abnormal keratinocyte proliferation and differentiation in skin disorders.

  • Severe psoriasis: reduces plaque formation and improves skin clearance.
  • Plaque psoriasis: helps control extensive lesions resistant to topical therapy.
  • Disorders of keratinization: normalizes skin scaling in conditions such as congenital ichthyosis.

How It Works

  • Acitretin binds to nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs), modulating gene expression that controls epidermal cell growth and differentiation. This action normalizes keratinization, reduces hyperproliferation of keratinocytes, and diminishes inflammatory mediators in the skin.

Side Effects

Acitretin may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Dry skin: increased xerosis and scaling.
  • Elevated triglycerides: hyperlipidaemia requiring monitoring.
  • Hair loss: temporary alopecia.
  • Cheilitis: cracked or inflamed lips.
  • Headache: mild to moderate intensity.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Hepatotoxicity: signs of liver dysfunction.
  • Pseudotumor cerebri: headache with visual changes.
  • Severe hyperlipidaemia: markedly high cholesterol or triglycerides.
  • Bone toxicity: premature epiphyseal closure in adolescents.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Depression or mood changes: rare psychiatric effects.

Precautions & Warnings

Before initiating therapy, clinicians should assess baseline labs and patient risk factors.

  • Pregnancy contraindication: Acitretin is teratogenic (Category X) and must not be used by women of childbearing potential.
  • Liver function: monitor hepatic enzymes regularly.
  • Lipid profile: check triglycerides and cholesterol before and during treatment.
  • Bone health: avoid use in growing adolescents due to risk of premature epiphyseal closure.
  • Concomitant vitamin A: avoid additional vitamin A supplements to reduce toxicity risk.
  • Store at ambient temperature: keep below 25°C, in the original packaging, protected from moisture and light.

Avoid Interactions

Acitretin can interact with several medications, altering efficacy or safety.

Major Interactions (Avoid)

  • Tetracyclines: increased risk of intracranial hypertension.
  • Vitamin A supplements: additive teratogenic and toxicity risk.
  • Oral contraceptives: reduced effectiveness; alternative contraception required.

Moderate Interactions (Monitor Closely)

  • Lipid‑lowering agents (e.g., fibrates, statins): may exacerbate hyperlipidaemia.
  • Antifungal azoles: potential for increased serum Acitretin levels.
  • Methotrexate: additive hepatotoxicity; monitor liver function.
  • Warfarin: possible alteration of INR; check coagulation parameters.

Frequently Asked Questions

Neotigason, containing the retinoid Acitretin, is indicated for the treatment of severe psoriasis and other disorders of keratinization such as congenital ichthyosis. It helps normalize skin cell growth and reduce scaling in these conditions.

Acitretin binds to nuclear retinoic acid and retinoid X receptors, influencing gene transcription that regulates epidermal cell proliferation and differentiation. This modulation restores normal keratinization and reduces the excessive skin cell turnover seen in psoriasis and related disorders.

The dosage of Neotigason is individualized by the prescribing physician based on the severity of the disease, patient weight, and laboratory parameters. Only a qualified healthcare professional should determine the appropriate dose and schedule.

Neotigason is classified as pregnancy Category X because Acitretin is highly teratogenic. It must not be used by women who are pregnant, planning to become pregnant, or breastfeeding. Effective contraception is required for women of childbearing potential throughout treatment and for a defined period after discontinuation.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with biologic agents, Acitretin is an oral retinoid that does not target specific immune pathways but modulates keratinocyte differentiation. It is often chosen for patients who prefer oral therapy or when biologics are contraindicated, though it may have a different side‑effect profile, especially concerning lipid levels and teratogenicity.

Neotigason tablets should be stored at ambient temperature, below 25 °C, in the original blister pack. Protect them from moisture, excessive heat, and direct sunlight to maintain stability and potency.

Neotigason is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not chewed or crushed. Dosing frequency and timing are determined by the prescribing clinician.

The most serious risks include teratogenicity, severe hyperlipidaemia, hepatotoxicity, and rare but severe skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored regularly for liver function, lipid levels, and any signs of serious skin or neurological adverse events.

Neotigason should be avoided in pregnant or nursing women, patients with uncontrolled liver disease, severe hyperlipidaemia, or a history of severe skin reactions. It is also contraindicated in children and adolescents whose growth plates have not yet closed due to the risk of premature epiphyseal closure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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