Product image of Neoton 500 (Phosphocreatine Sodium) supplied by GNH India

Neoton 500

Active Ingredient:
Phosphocreatine Sodium
Origin:
EU

Neoton 500 (Phosphocreatine Sodium)

Phosphocreatine Sodium, the active ingredient in Neoton 500, is a metabolic agent presented as a sterile solution for intramuscular use. It is employed to support myocardial energy metabolism in patients with cardiac conditions such as ischemia, heart failure, or during cardiac surgery.

GNH India supplies Neoton 500 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Alfasigma S.P.A.

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Indications & Clinical Uses

  • Neoton 500 is used to address cardiac energy deficits and protect myocardial tissue in several clinical scenarios.
  • Myocardial Ischemia: improves cellular energy supply during reduced blood flow.
  • Heart Failure: supports cardiac muscle energetics to enhance contractile function.
  • Cardiac Surgery: used perioperatively to protect the myocardium from ischemic injury.

How It Works

  • Phosphocreatine Sodium acts as a rapid phosphate donor in the creatine kinase reaction, regenerating ATP from ADP in high‑energy demand tissues. By replenishing intracellular ATP stores, it helps maintain myocardial contractility and cellular viability during periods of limited oxygen or nutrient supply.

Side Effects

Adverse reactions may occur following intramuscular administration of phosphocreatine sodium.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the site.
  • Local erythema: redness or mild swelling.
  • Nausea: transient upset stomach.
  • Dizziness: temporary light‑headedness.
  • Headache: mild to moderate intensity.
  • Low‑grade fever: short‑lasting temperature rise.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Cardiac arrhythmia: abnormal heart rhythm potentially life‑threatening.
  • Severe hypotension: marked drop in blood pressure.
  • Electrolyte imbalance: abnormal serum potassium or calcium levels.
  • Thrombophlebitis: inflammation of a vein with clot formation.
  • Renal impairment: reduced kidney function in susceptible individuals.

Precautions & Warnings

  • Prior to using Neoton 500, several safety considerations should be observed.
  • Allergy assessment: verify no known hypersensitivity to phosphocreatine.
  • Cardiac monitoring: observe for arrhythmias during and after administration.
  • Renal function: assess kidney function before use.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Concomitant medications: review for agents affecting electrolyte balance.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Phosphocreatine sodium may interact with other medicines; some combinations require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • High‑dose catecholamines: may exacerbate cardiac stress.
  • Potassium‑sparing diuretics: increased risk of hyperkalemia.
  • Anticoagulants: heightened bleeding risk at injection site.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: monitor heart rate and blood pressure.
  • ACE inhibitors: watch for additive hypotensive effects.
  • Electrolyte supplements: monitor serum electrolyte levels.

Frequently Asked Questions

Neoton 500 contains phosphocreatine sodium and is used to support myocardial energy metabolism in conditions such as myocardial ischemia, heart failure, and during cardiac surgery. It helps maintain ATP levels in heart muscle cells, which can improve cardiac performance under stress.

Phosphocreatine sodium serves as a rapid phosphate donor in the creatine kinase system, converting ADP back to ATP. This rapid regeneration of ATP supplies energy to cardiac cells during periods of limited oxygen or nutrient delivery, helping preserve contractile function.

The dosage of Neoton 500 is determined by the prescribing clinician based on the patient’s condition, weight, and clinical response. Healthcare professionals calculate the appropriate amount and frequency according to established medical guidelines.

Safety data for phosphocreatine sodium in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Neoton 500, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Neoton 500 provides direct ATP regeneration via phosphocreatine, whereas many other agents act indirectly by improving blood flow or reducing workload. Compared with agents like trimetazidine, phosphocreatine offers a rapid, substrate‑based energy boost, but clinical choice depends on patient profile and therapeutic goals.

Neoton 500 should be stored at ambient temperature, away from direct sunlight and moisture. Keep the vial in its original packaging until use, and avoid exposing it to extreme temperatures or humidity to maintain product stability.

Neoton 500 is administered by intramuscular injection. A qualified healthcare professional selects an appropriate injection site, prepares the sterile solution according to aseptic technique, and injects the prescribed volume into the muscle.

Serious risks include anaphylactic reactions, severe cardiac arrhythmias, profound hypotension, electrolyte disturbances, thrombophlebitis, and renal impairment. Patients should be monitored closely for any signs of these events, especially during the initial administration.

Neoton 500 should be avoided in individuals with known hypersensitivity to phosphocreatine sodium, severe uncontrolled cardiac arrhythmias, significant renal dysfunction, or in patients where the risk of allergic reaction outweighs potential benefit. Clinicians must assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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