Product image of Neoton Phlebo (Phosphocreatine Sodium) supplied by GNH India

Neoton Phlebo

Active Ingredient:
Phosphocreatine Sodium
Origin:
EU

Neoton Phlebo (Phosphocreatine Sodium)

Phosphocreatine Sodium, the active ingredient in Neoton Phlebo, is a metabolic agent presented as an intravenous solution for injection use. It is employed to support myocardial energy metabolism during ischemic events and cardiac procedures.

GNH India supplies Neoton Phlebo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

Manufacturer / TM Owner

Alfasigma S.P.A.

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Indications & Clinical Uses

Neoton Phlebo is used in clinical settings that involve myocardial energy compromise and cardiac surgery.

  • Acute myocardial ischemia: helps restore ATP levels in ischemic heart muscle.
  • Cardiac surgery (ischemia‑reperfusion): provides cardioprotection during cardiopulmonary bypass.
  • Heart failure exacerbations: supports myocardial energetics when oxygen supply is limited.

How It Works

  • Phosphocreatine Sodium donates phosphate groups to ADP, rapidly regenerating ATP within ischemic myocardial cells. By replenishing intracellular high‑energy phosphates, it helps maintain contractile function and cellular viability during periods of reduced oxygen delivery.

Side Effects

Neoton Phlebo may be associated with a range of adverse reactions following intravenous administration.

Common Side Effects

  • Infusion site pain or erythema
  • Transient hypotension
  • Nausea or vomiting
  • Headache
  • Flushing
  • Dizziness

Serious or Rare Side Effects

  • Severe hypotension or cardiovascular collapse
  • Cardiac arrhythmias
  • Anaphylactic or severe allergic reaction
  • Cardiac arrest
  • Pulmonary edema
  • Thrombophlebitis at the infusion site

Precautions & Warnings

Neoton Phlebo should be administered under close medical supervision with attention to patient‑specific factors.

  • Renal impairment: adjust infusion rate and monitor renal function.
  • Hepatic dysfunction: use cautiously, observe liver enzymes.
  • Electrolyte imbalance: correct potassium or calcium disturbances before infusion.
  • Cardiac monitoring: continuous ECG and blood pressure monitoring during administration.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential drug interactions may modify the safety or efficacy of Neoton Phlebo.

Major Interactions (Avoid)

  • Concurrent use with other high‑dose phosphate donors or creatine derivatives: risk of metabolic overload.
  • Strong vasodilators (e.g., nitroprusside) combined with rapid infusion: may precipitate severe hypotension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt compensatory heart rate response.
  • Calcium channel blockers: monitor for additive negative inotropic effects.
  • Diuretics: watch electrolyte shifts, especially potassium.
  • Anticoagulants: observe for bleeding if infusion causes vascular irritation.

Frequently Asked Questions

Neoton Phlebo is an intravenous formulation of phosphocreatine sodium used to support myocardial energy metabolism during acute ischemic events, cardiac surgery, and certain heart failure situations where oxygen delivery to the heart muscle is compromised.

Phosphocreatine sodium serves as a rapid phosphate donor, converting ADP back to ATP within heart cells. This replenishment of high‑energy phosphates helps maintain contractile function and cell viability during periods of reduced oxygen supply.

The specific dose and infusion rate of Neoton Phlebo are determined by the prescribing physician based on the patient’s clinical condition, weight, and renal function. Dosage details are provided in the product’s prescribing information.

Safety data for phosphocreatine sodium in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Neoton Phlebo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Neoton Phlebo provides direct ATP regeneration via phosphate donation, whereas other agents such as beta‑blockers or nitrates act by reducing myocardial oxygen demand or improving coronary flow. The choice depends on the clinical scenario, and Neoton Phlebo is typically used as an adjunct to standard therapies.

Neoton Phlebo should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until ready for use.

Neoton Phlebo is administered intravenously by a qualified healthcare professional. The solution is infused over a controlled period, usually under continuous cardiac and hemodynamic monitoring, to ensure safe delivery and response.

Serious risks include severe hypotension, cardiac arrhythmias, anaphylactic reactions, and cardiac arrest. Prompt recognition and immediate medical intervention are essential if any of these events occur during or after infusion.

Neoton Phlebo should be avoided in patients with known hypersensitivity to phosphocreatine sodium or any excipients, and used with caution in individuals with severe renal or hepatic impairment, uncontrolled electrolyte disturbances, or unstable hemodynamic status.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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