Product image of Neoton (Phosphocreatine Sodium) supplied by GNH India

Neoton

Active Ingredient:
Phosphocreatine Sodium
Origin:
EU

Neoton (Phosphocreatine Sodium)

Phosphocreatine sodium, the active ingredient in Neoton, is a creatine phosphate presented as a solution for injection for intravenous use. It provides exogenous phosphocreatine to support myocardial energy metabolism in patients with ischemic heart disease, heart failure, and during cardiac surgery.
GNH India supplies Neoton as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Alfasigma Polska

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Indications & Clinical Uses

  • Neoton acts on cardiac energy metabolism and is employed in several cardioprotective contexts.
  • Myocardial ischemia: improves myocardial ATP regeneration during reduced blood flow.
  • Heart failure: supports cardiac contractility by enhancing cellular energy stores.
  • Cardiac surgery support: maintains myocardial energy balance during operative stress.

How It Works

  • Phosphocreatine sodium delivers phosphocreatine directly to cardiac cells, where it serves as a rapid phosphate donor to ADP, regenerating ATP via the creatine kinase reaction. By increasing intracellular phosphocreatine pools, it sustains oxidative phosphorylation and preserves myocardial contractile function during ischemic or high‑stress conditions.

Side Effects

Adverse reactions may occur with intravenous administration of phosphocreatine sodium solutions.

Common Side Effects

  • Injection site pain or erythema.
  • Mild hypotension or transient dizziness.
  • Nausea or mild gastrointestinal discomfort.
  • Headache.
  • Transient flushing.

Serious or Rare Side Effects

  • Severe hypotension or cardiovascular collapse.
  • Cardiac arrhythmias.
  • Anaphylactic or severe allergic reactions.
  • Hyperkalemia.
  • Worsening of myocardial infarction symptoms.

Precautions & Warnings

  • Neoton should be used with careful clinical monitoring.
  • Assess cardiac function: obtain baseline ECG and cardiac biomarkers before infusion.
  • Monitor hemodynamics: observe blood pressure and heart rate during and after administration.
  • Review electrolyte status: correct significant imbalances prior to use.
  • Avoid in uncontrolled arrhythmias: defer use if severe rhythm disturbances are present.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential drug interactions require attention when prescribing Neoton.

Major Interactions (Avoid)

  • Concurrent high‑dose catecholamines: may increase risk of life‑threatening arrhythmias.
  • Co‑administration with other ATP‑modulating agents: can cause metabolic instability.

Moderate Interactions (Monitor Closely)

  • Diuretics: monitor electrolytes and volume status.
  • Beta‑blockers: watch for additive hypotensive effects.
  • ACE inhibitors or ARBs: assess renal function and blood pressure.
  • Anticoagulants: observe for bleeding tendencies due to hemodynamic changes.

Frequently Asked Questions

Neoton is an intravenous solution of phosphocreatine sodium used as a cardioprotective agent. It is indicated for patients with myocardial ischemia, heart failure, and for supporting cardiac function during cardiac surgery by helping to replenish myocardial ATP stores.

Phosphocreatine sodium provides an external source of phosphocreatine, which donates phosphate groups to ADP via the creatine kinase system. This rapid regeneration of ATP supports myocardial energy metabolism, especially during periods of reduced oxygen supply, helping to maintain contractile function.

The specific dose of Neoton is determined by the prescribing clinician based on the patient’s condition, weight, and clinical response. Healthcare professionals set the infusion rate and total amount according to established protocols and individual therapeutic needs.

Safety data for phosphocreatine sodium in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Neoton, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and necessary import documentation.

Neoton delivers phosphocreatine directly, targeting rapid ATP regeneration, whereas many other cardioprotective drugs act through vasodilation, beta‑blockade, or metabolic modulation. This direct energy‑support mechanism can be advantageous in acute ischemic settings, but clinical choice depends on patient profile and therapeutic goals.

Neoton must be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the solution. Before use, inspect the vial for particulate matter or discoloration and allow it to reach room temperature if required for administration.

Neoton is administered intravenously as a sterile solution for injection. The infusion is typically given over a controlled period under medical supervision, with vital signs monitored throughout the procedure to detect any hemodynamic changes.

Serious risks include severe hypotension, cardiac arrhythmias, anaphylactic reactions, hyperkalemia, and potential worsening of myocardial infarction symptoms. Immediate medical attention is required if any of these events occur during or after infusion.

Neoton is contraindicated in patients with known hypersensitivity to phosphocreatine sodium or any excipients in the formulation, and in those with uncontrolled cardiac arrhythmias or severe hemodynamic instability. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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