Product image of Nephromag (Buffered Phosphate Solution | Mertiatide) supplied by GNH India

Nephromag

Active Ingredient:
Buffered Phosphate Solution | Mertiatide
Origin:
EU

Nephromag (Buffered Phosphate Solution | Mertiatide)

Buffered Phosphate Solution / Mertiatide, the active ingredient in Nephromag, is a buffered phosphate formulation presented as an intravenous solution for infusion use. It helps restore phosphate balance in patients requiring intravenous phosphate supplementation.

GNH India supplies Nephromag as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rotop Pharmaka Gmbh

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Indications & Clinical Uses

Nephromag, a buffered phosphate solution, is used to manage disorders related to phosphate deficiency.

  • Hypophosphatemia: correction of low serum phosphate levels in acute or chronic settings.
  • Renal replacement therapy: provides phosphate in dialysis fluids to maintain electrolyte balance.
  • Parenteral nutrition: supplies phosphate as part of total nutrient admixtures for patients unable to take oral intake.

How It Works

  • Mertiatide delivers phosphate ions in a buffered aqueous medium, allowing rapid equilibration with plasma phosphate pools. The buffer stabilises pH during infusion, facilitating safe delivery of phosphate while minimizing shifts in acid‑base balance. Restored phosphate supports cellular energy metabolism, bone mineralisation, and intracellular signalling pathways.

Side Effects

Nephromag may be associated with a range of infusion‑related reactions.

Common Side Effects

  • Transient hyperphosphatemia
  • Mild nausea
  • Headache
  • Infusion site irritation
  • Mild electrolyte shifts
  • Transient hypotension

Serious or Rare Side Effects

  • Severe hyperphosphatemia leading to calcium‑phosphate precipitation
  • Anaphylactic or severe allergic reaction
  • Exacerbation of renal failure
  • Metabolic acidosis
  • Cardiac arrhythmia
  • Life‑threatening hypotension

Precautions & Warnings

When using Nephromag, clinicians should observe several safety measures.

  • Dose adjustment: monitor serum phosphate and calcium levels during therapy.
  • Renal function: assess kidney function before and during infusion.
  • Cardiac status: watch for arrhythmias in patients with electrolyte disturbances.
  • Concurrent calcium therapy: avoid simultaneous high‑calcium infusion to prevent precipitation.
  • Pregnancy and lactation: use only if clearly needed and benefits outweigh potential risks.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Nephromag can interact with other agents that affect phosphate or calcium balance.

Major Interactions (Avoid)

  • Calcium‑containing solutions: risk of calcium‑phosphate precipitation.
  • Aluminum‑containing antacids: may bind phosphate and reduce efficacy.
  • High‑dose vitamin D analogues: can exacerbate hyperphosphatemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may alter electrolyte balance, requiring serum monitoring.
  • ACE inhibitors or ARBs: monitor renal function and phosphate levels.
  • Iron sucrose: may cause transient changes in phosphate concentrations.

Frequently Asked Questions

Nephromag is an intravenous buffered phosphate solution used to correct low serum phosphate levels, support electrolyte balance during renal replacement therapy, and provide phosphate in parenteral nutrition formulations for patients who cannot receive oral intake.

Mertiatide supplies phosphate ions in a buffered medium, allowing rapid equilibration with the body’s phosphate pool while maintaining pH stability. Restored phosphate supports cellular energy processes, bone mineralisation, and intracellular signalling.

The appropriate dose of Nephromag is determined by the prescribing clinician based on the patient’s serum phosphate level, renal function, and overall clinical condition. Dosage regimens are individualized and not publicly standardized.

Safety data for Nephromag in pregnancy and lactation are limited. It should only be used when clearly needed and when the potential benefit justifies any possible risk to the mother or infant.

To order Nephromag, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and import documentation.

Nephromag is a buffered formulation, which helps maintain solution pH and reduces the risk of precipitation compared with non‑buffered phosphate preparations. This can allow more flexible infusion rates while providing the same phosphate repletion effect.

Nephromag should be stored at ambient temperature, kept in its original packaging, and protected from light and moisture. Do not freeze the product, and inspect the container for any signs of damage before use.

Nephromag is administered intravenously. The solution is typically diluted in compatible IV fluids and infused over a period defined by the prescriber, with close monitoring of serum phosphate and calcium levels throughout the infusion.

Serious risks include severe hyperphosphatemia, calcium‑phosphate precipitation that can lead to vascular calcification, anaphylactic reactions, metabolic acidosis, and cardiac arrhythmias. Prompt recognition and management of these events are essential.

Nephromag should be avoided in patients with existing hyperphosphatemia, uncontrolled hypercalcemia, severe renal failure where phosphate clearance is impaired, or known hypersensitivity to any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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