Product image of Nephromag (Buffered Phosphate Solution | Mertiatide) supplied by GNH India

Nephromag

Active Ingredient:
Buffered Phosphate Solution | Mertiatide
Origin:
EU

Nephromag (Buffered Phosphate Solution | Mertiatide)

Mertiatide, the active ingredient in Nephromag, is a buffered phosphate solution presented as an intravenous solution for use in clinical settings. It helps correct phosphate deficits and supports acid‑base balance in patients with renal impairment or undergoing dialysis.

GNH India supplies Nephromag as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, dialysis clinics and other healthcare facilities worldwide.

Manufacturer / TM Owner

Rotop Pharmaka Gmbh

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Indications & Clinical Uses

Nephromag (Mertiatide) is used to manage phosphate homeostasis in conditions associated with phosphate depletion.

  • Hypophosphatemia: restores serum phosphate levels in patients with low phosphate.
  • Phosphate depletion during continuous renal replacement therapy: provides controlled phosphate repletion to maintain metabolic balance.
  • Renal osteodystrophy: assists in correcting phosphate abnormalities in chronic kidney disease.

How It Works

  • Mertiatide delivers phosphate ions in a buffered aqueous medium, allowing rapid increase of extracellular phosphate concentrations while minimizing pH shifts. The phosphate acts as a substrate for cellular metabolism and bone mineralization, and the buffering component helps stabilize blood pH during infusion. The solution is designed for intravenous administration, enabling direct delivery into the bloodstream for immediate therapeutic effect.

Side Effects

Common Side Effects

  • Hyperphosphatemia: elevated serum phosphate levels.
  • Hypocalcemia: reduced calcium levels due to phosphate binding.
  • Infusion site irritation: redness or discomfort at the injection site.
  • Nausea or vomiting.
  • Transient fever or chills.
  • Electrolyte imbalance: changes in potassium or magnesium.

Serious or Rare Side Effects

  • Severe hyperphosphatemia leading to calcium‑phosphate precipitation.
  • Anaphylactic reaction: difficulty breathing, rash, swelling.
  • Metabolic acidosis: significant pH disturbance.
  • Acute renal failure worsening.
  • Cardiac arrhythmias associated with electrolyte shifts.
  • Disseminated intravascular coagulation (rare).

Precautions & Warnings

Nephromag should be administered under close clinical monitoring.

  • Serum phosphate monitoring: check levels before and during therapy.
  • Calcium balance: avoid concurrent high calcium infusions to prevent precipitation.
  • Renal function: adjust use in patients with severe renal impairment.
  • Infusion rate: administer slowly to reduce risk of electrolyte shifts.
  • Contraindications: do not use in patients with existing hyperphosphatemia.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential drug interactions require careful assessment.

Major Interactions (Avoid)

  • Calcium-containing products: risk of calcium‑phosphate precipitation.
  • Vitamin D analogues: may exacerbate hypercalcemia.
  • High-dose phosphate binders: can lead to excessive phosphate levels.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increase renal phosphate excretion.
  • ACE inhibitors: may affect renal handling of electrolytes.
  • NSAIDs: can alter renal perfusion and phosphate clearance.
  • Antacids containing aluminum or magnesium: may interfere with phosphate absorption.

Frequently Asked Questions

Nephromag contains Mertiatide, a buffered phosphate solution administered intravenously to correct low phosphate levels and support acid‑base balance in patients with renal impairment, dialysis‑related phosphate loss, or other conditions causing phosphate depletion.

Mertiatide provides phosphate ions in a buffered medium, quickly raising serum phosphate while maintaining pH stability. The phosphate serves as a substrate for cellular metabolism and bone health, and the buffering component helps prevent significant shifts in blood acidity during infusion.

The dose of Nephromag is individualized by the prescribing clinician based on the patient’s serum phosphate level, renal function, and clinical condition. Healthcare professionals determine the appropriate volume and infusion rate for each case.

Safety of Nephromag in pregnancy or lactation has not been fully established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Nephromag, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Nephromag offers a buffered formulation that helps maintain pH stability during infusion, which can reduce the risk of acid‑base disturbances compared with non‑buffered phosphate solutions. Its intravenous route allows rapid correction of phosphate deficits, making it suitable for acute settings such as dialysis or intensive care.

Nephromag should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution. Before use, inspect for particulate matter and ensure the product is at the appropriate temperature for infusion.

Nephromag is administered intravenously, typically via a controlled infusion pump. The infusion rate and total volume are set by the treating physician according to the patient’s laboratory values and clinical response, with regular monitoring of serum phosphate and calcium.

Serious risks include severe hyperphosphatemia leading to calcium‑phosphate precipitation, anaphylactic reactions, metabolic acidosis, and worsening renal function. Prompt recognition and management of these events are essential, and patients should be monitored closely during and after infusion.

Nephromag is contraindicated in patients with existing hyperphosphatemia, uncontrolled calcium overload, or known hypersensitivity to any component of the formulation. Clinicians should also exercise caution in patients with severe renal failure or those receiving high doses of calcium or vitamin D.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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