Product image of Nephromag (Buffered Phosphate Solution | Mertiatide) supplied by GNH India

Nephromag

Active Ingredient:
Buffered Phosphate Solution | Mertiatide
Origin:
EU

Nephromag (Buffered Phosphate Solution | Mertiatide)

Buffered Phosphate Solution, the active ingredient in Nephromag, is a pharmaceutical preparation presented as an intravenous solution for IV use. It is employed to manage phosphate balance in clinical settings where electrolyte control is required. GNH India supplies Nephromag as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide.

Manufacturer / TM Owner

Rotop Pharmaka Gmbh

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Indications & Clinical Uses

Nephromag provides buffered phosphate for conditions that require intravenous electrolyte management.

  • Hypophosphatemia: helps restore normal serum phosphate levels in patients with low phosphate.
  • Renal replacement therapy: used as part of dialysis solutions to maintain phosphate balance.
  • Major surgery: administered to support electrolyte homeostasis during extensive operative procedures.

How It Works

  • Mertiatide delivers phosphate ions in a buffered solution that integrates into the body's phosphate pool, supporting cellular energy metabolism and acid‑base equilibrium. The buffer component helps maintain physiological pH while the phosphate contributes to bone mineralization, ATP synthesis, and renal excretion pathways.

Side Effects

Nephromag may be associated with a range of adverse reactions following intravenous administration.

Common Side Effects

  • Mild nausea
  • Transient headache
  • Local irritation at infusion site
  • Slight increase in serum phosphate
  • Mild hypotension during rapid infusion
  • Temporary dizziness

Serious or Rare Side Effects

  • Hyperphosphatemia leading to calcium precipitation
  • Severe hypocalcemia
  • Allergic anaphylactic reaction
  • Acute renal failure in susceptible patients

Precautions & Warnings

Nephromag should be used with careful clinical monitoring.

  • Serum phosphate monitoring: check levels before and during therapy.
  • Calcium balance: watch for hypocalcemia, especially when co‑administered with calcium salts.
  • Renal function: assess kidney performance prior to infusion.
  • Infusion rate: administer slowly to reduce risk of hypotension.
  • Contraindications: avoid in patients with known hyperphosphatemia.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Nephromag may interact with other agents affecting electrolyte balance.

Major Interactions (Avoid)

  • Calcium supplements: can precipitate calcium phosphate.
  • Iron dextran: may enhance phosphate binding and reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may alter renal phosphate handling.
  • Vitamin D analogues: influence calcium‑phosphate metabolism.
  • Antacids containing aluminum or magnesium: affect phosphate absorption.

Frequently Asked Questions

Nephromag is a buffered phosphate solution administered intravenously to help restore and maintain normal phosphate levels in patients with hypophosphatemia, support electrolyte balance during renal replacement therapy, and assist in managing phosphate homeostasis during major surgical procedures.

Mertiatide provides phosphate ions within a buffered carrier, allowing rapid incorporation into the body's phosphate pool. This supports cellular energy production, bone mineralization, and helps stabilize blood pH while the buffer maintains a physiologic environment during infusion.

The dosage of Nephromag is determined by the prescribing clinician based on the patient’s serum phosphate level, renal function, and overall clinical condition. The prescriber sets the appropriate concentration and infusion rate for each individual case.

Safety data for Nephromag in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Nephromag offers a buffered formulation that helps maintain pH stability during infusion, which can reduce the risk of local irritation compared with non‑buffered phosphate preparations. Clinical choice depends on physician preference, patient tolerance, and specific therapeutic goals.

Nephromag should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any solution that appears discolored or contains particles.

Nephromag is given intravenously, typically diluted in compatible IV fluids and infused over a controlled period as directed by the prescriber. Administration rate and volume are adjusted according to the patient’s clinical status and laboratory results.

Serious risks include hyperphosphatemia leading to calcium phosphate precipitation, severe hypocalcemia, and rare anaphylactic reactions. Monitoring serum phosphate and calcium levels during therapy is essential to mitigate these risks.

Nephromag should be avoided in patients with known hyperphosphatemia, uncontrolled calcium disorders, or a history of severe allergic reactions to its components. Clinicians should also exercise caution in individuals with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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