Product image of Nephrotect (Acetylcysteine, Glycine, L-Lysine Acetate, L-Tryptophan, Glycyl-Tyrosine, L-Arginine, L-Histidine, L) supplied by GNH India

Nephrotect

Active Ingredient:
Acetylcysteine, Glycine, L-Lysine Acetate, L-Tryptophan, Glycyl-Tyrosine, L-Arginine, L-Histidine, L
Origin:
EU

Nephrotect (Acetylcysteine, Glycine, L-Lysine Acetate, L-Tryptophan, Glycyl-Tyrosine, L-Arginine, L-Histidine, L)

Acetylcysteine, Glycine, L‑Lysine Acetate, L‑Tryptophan, Glycyl‑Tyrosine, L‑Arginine, L‑Histidine, the active ingredients in Nephrotect, are a nutritional supplement presented as an intravenous solution for intravenous use. It supports renal function and may be used in patients at risk of kidney injury, including those undergoing contrast studies or transplantation.

GNH India supplies Nephrotect as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Deutschland Gmbh

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Indications & Clinical Uses

Nephrotect is used as a renal‑support supplement that targets oxidative stress and metabolic pathways involved in kidney injury.

  • Acute kidney injury: helps mitigate oxidative damage and supports recovery of renal function.
  • Contrast‑induced nephropathy: provides antioxidant precursors that may reduce the incidence of contrast‑related renal impairment.
  • Chronic kidney disease adjunct: supplies amino acids that contribute to cellular protection and metabolic balance.
  • Renal transplantation support: assists in maintaining graft function by enhancing antioxidant capacity.

How It Works

  • Nephrotect delivers a blend of cysteine‑derived and basic amino acids that serve as substrates for intracellular glutathione synthesis, enhancing antioxidant defenses. The formulation also supplies nitric‑oxide precursors and substrates for protein synthesis, promoting vasodilation, endothelial stability, and cellular repair processes within renal tissue, thereby helping to counteract oxidative stress and metabolic dysfunction associated with kidney injury.

Side Effects

Nephrotect is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Mild nausea or vomiting.
  • Transient flushing or warmth at the infusion site.
  • Low‑grade headache.
  • Slight elevation of liver enzymes.
  • Mild hypotension during rapid infusion.

Serious or Rare Side Effects

  • Anaphylactoid reactions, including rash, bronchospasm, or angioedema.
  • Severe hypotension requiring medical intervention.
  • Acute hemolysis in patients with glucose‑6‑phosphate dehydrogenase deficiency.
  • Renal tubular necrosis if administered inappropriately.
  • Persistent elevation of serum creatinine despite therapy.

Precautions & Warnings

Nephrotect should be used with clinical oversight and appropriate monitoring.

  • Patient assessment: evaluate renal function and baseline labs before initiation.
  • Infusion rate: administer slowly to reduce risk of hypotension and flushing.
  • Allergy history: screen for known hypersensitivity to any component.
  • G6PD deficiency: avoid or monitor closely due to risk of hemolysis.
  • Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Nephrotect may interact with other agents that affect oxidative balance or renal hemodynamics.

Major Interactions (Avoid)

  • High‑dose N‑acetylcysteine oral formulations: risk of cumulative sulfhydryl overload.
  • Potent vasodilators (e.g., nitroprusside): may exacerbate hypotension.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: monitor electrolytes and volume status.
  • ACE inhibitors or ARBs: watch for additive effects on renal perfusion.
  • Anticoagulants: observe for any changes in bleeding tendency due to altered platelet function.

Frequently Asked Questions

Nephrotect is a nutritional supplement formulated for intravenous administration to support renal function. It is used in clinical settings to help protect the kidneys from oxidative stress, assist recovery from acute kidney injury, reduce the risk of contrast‑induced nephropathy, and serve as an adjunct in chronic kidney disease and renal transplantation care.

The acetylcysteine component provides cysteine, a key precursor for glutathione, the body’s primary intracellular antioxidant. The additional amino acids (glycine, lysine acetate, tryptophan, glycyl‑tyrosine, arginine, histidine) support nitric‑oxide production, protein synthesis, and cellular repair pathways, collectively enhancing antioxidant capacity and renal blood flow.

The dose of Nephrotect is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and treatment setting. Healthcare professionals set the appropriate infusion volume and rate according to established clinical protocols.

Safety data for Nephrotect in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed), and import documentation.

Compared with single‑ingredient agents such as plain acetylcysteine, Nephrotect offers a broader amino‑acid profile that targets multiple metabolic pathways, potentially providing more comprehensive antioxidant and vasodilatory effects. However, clinical choice depends on specific patient needs, existing protocols, and physician judgment.

Nephrotect must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. If the product reaches room temperature, it should be used promptly and not re‑refrigerated.

Nephrotect is given intravenously. The solution is diluted according to the prescribing information and infused over a period defined by the treating clinician, typically using a controlled infusion pump to ensure a steady rate and minimize infusion‑related reactions.

Serious risks include anaphylactoid reactions such as rash, bronchospasm, or angioedema, severe hypotension during rapid infusion, and rare cases of hemolysis in patients with glucose‑6‑phosphate dehydrogenase deficiency. Prompt recognition and medical management are essential if these events occur.

Nephrotect should be avoided in patients with known hypersensitivity to any of its components, those with confirmed G6PD deficiency due to hemolysis risk, and individuals who cannot tolerate intravenous infusions. Clinicians should also exercise caution in patients receiving multiple vasodilators or high‑dose antioxidant therapies.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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