Product image of Nephrotect (Valine, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine) supplied by GNH India

Nephrotect

Active Ingredient:
Valine, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine
Origin:
EU

Nephrotect (Valine, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine)

Valine, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, the active ingredients in Nephrotect, are an amino acid solution presented as an intravenous solution for parenteral use. It supports patients with renal failure requiring replacement therapy, those who cannot receive enteral feeding, and helps prevent protein‑energy malnutrition.
GNH India supplies Nephrotect as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Deutschland Gmbh

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Indications & Clinical Uses

Nephrotect is used in clinical situations that require comprehensive amino acid supplementation via the parenteral route.

  • Renal failure requiring renal replacement therapy: provides essential amino acids to maintain nitrogen balance and support protein synthesis.
  • Parenteral nutrition for patients unable to receive enteral feeding: supplies a complete amino acid profile for metabolic needs.
  • Prevention and treatment of protein‑energy malnutrition: helps restore nutritional status and muscle mass in critically ill patients.

How It Works

  • Nephrotect delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream, bypassing the gastrointestinal tract. These amino acids serve as substrates for protein synthesis, replenish nitrogen stores, and support cellular metabolism. By restoring the amino acid pool, the solution helps maintain nitrogen balance, promote tissue repair, and sustain metabolic functions during periods when oral or enteral nutrition is not feasible.

Side Effects

Nephrotect may be associated with infusion‑related and metabolic reactions.

Common Side Effects

  • Infusion site erythema or pain
  • Mild nausea or vomiting
  • Transient hypernatremia
  • Elevated serum urea levels
  • Mild metabolic alkalosis

Serious or Rare Side Effects

  • Anaphylactic or severe hypersensitivity reaction
  • Severe metabolic acidosis
  • Bronchospasm or respiratory distress
  • Hemodynamic instability during rapid infusion

Precautions & Warnings

Nephrotect requires careful monitoring and appropriate handling to minimise risks.

  • Renal function monitoring: assess serum creatinine and urea regularly.
  • Electrolyte balance: watch for changes in sodium, potassium, and calcium levels.
  • Blood glucose monitoring: amino acid solutions can affect glucose metabolism.
  • Hypersensitivity: avoid in patients with known allergy to any component.
  • Hepatic impairment: use with caution as metabolism may be altered.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Nephrotect can interact with other intravenous solutions and medications that affect electrolyte or metabolic balance.

Major Interactions (Avoid)

  • Concurrent high‑dose potassium solutions: risk of hyperkalemia.
  • Mixing with calcium chloride or phosphate solutions: may cause precipitation.

Moderate Interactions (Monitor Closely)

  • Diuretics: can exacerbate electrolyte shifts.
  • Parenteral lipid emulsions: may influence amino acid utilization.
  • Renal replacement therapy: may remove amino acids, requiring dose adjustment.

Frequently Asked Questions

Nephrotect is an intravenous amino acid solution used to provide essential amino acids for patients who cannot receive enteral nutrition, those undergoing renal replacement therapy, and individuals at risk of protein‑energy malnutrition. It helps maintain nitrogen balance and supports protein synthesis during parenteral nutrition.

The mixture supplies a balanced set of essential and non‑essential amino acids directly into the bloodstream. These amino acids act as building blocks for protein synthesis, replenish nitrogen stores, and support cellular metabolism, which is crucial when oral or enteral intake is insufficient or impossible.

The dose of Nephroprotect is individualized by the prescribing clinician based on the patient’s nutritional requirements, renal function, and overall clinical condition. Healthcare professionals calculate the appropriate volume and rate of infusion to meet the specific amino acid needs of each patient.

The safety of Nephroprotect in pregnancy or lactation has not been established. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Nephroprotect, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Nephroprotect offers a comprehensive amino acid profile specifically formulated for renal patients and those at risk of protein‑energy malnutrition. Compared with generic amino acid solutions, it includes a balanced mix of essential amino acids that may better support nitrogen balance and reduce the risk of metabolic complications in these populations.

Nephroprotect must be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution. Before administration, inspect for particulate matter or discoloration and use within the recommended time after opening.

Nephroprotect is administered intravenously, typically via a peripheral or central venous catheter. The infusion rate is determined by the prescribing clinician and may be adjusted based on the patient’s metabolic response, fluid balance, and electrolyte status.

Serious risks include anaphylactic or severe hypersensitivity reactions, severe metabolic acidosis, and bronchospasm. Patients should be monitored closely during infusion for any signs of allergic response, respiratory distress, or significant changes in acid‑base balance.

Nephroprotect should be avoided in patients with known hypersensitivity to any of its amino acid components. Caution is also advised for individuals with severe hepatic impairment, uncontrolled electrolyte disturbances, or those receiving incompatible intravenous solutions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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