Product image of Neqlofol (Beclometasone Dipropionate, Formoterol Fumarate Dihydrate) supplied by GNH India

Neqlofol

Active Ingredient:
Beclometasone Dipropionate, Formoterol Fumarate Dihydrate
Origin:
EU

Neqlofol (Beclometasone Dipropionate, Formoterol Fumarate Dihydrate)

Beclometasone dipropionate, the active ingredient in Neqlofol, is a corticosteroid/long‑acting β2‑agonist combination presented as an inhalation product for respiratory use. It is formulated to deliver anti‑inflammatory and bronchodilator effects for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD) in adults.

GNH India supplies Neqlofol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance and reliable logistics for global distribution.

Manufacturer / TM Owner

Alkaloid-Int D.O.O.

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Indications & Clinical Uses

  • Neqlofol is indicated for the maintenance treatment of respiratory diseases affecting airway inflammation and bronchoconstriction.
  • Asthma: improves symptom control and reduces exacerbations
  • Chronic obstructive pulmonary disease (COPD): enhances lung function and lowers risk of flare‑ups
  • Bronchial hyperresponsiveness (including exercise‑induced): helps prevent airway narrowing during triggers

How It Works

  • Beclometasone dipropionate activates glucocorticoid receptors in airway cells, suppressing inflammatory gene expression and reducing cytokine production. Formoterol fumarate binds to β2‑adrenergic receptors on airway smooth muscle, stimulating adenylate cyclase and increasing cyclic AMP, which leads to rapid and sustained bronchodilation. The combined actions provide both anti‑inflammatory and long‑acting bronchodilator effects for chronic respiratory disease management.

Side Effects

Neqlofol may cause a range of adverse reactions, which are generally classified by frequency.

Common Side Effects

  • Oral thrush (candidiasis): fungal infection in the mouth
  • Hoarseness or voice change: irritation of the vocal cords
  • Cough: irritation from inhaled particles
  • Headache: mild to moderate discomfort

Serious or Rare Side Effects

  • Paradoxical bronchospasm: sudden worsening of breathing
  • Adrenal suppression: reduced cortisol production with long‑term use
  • Severe allergic reaction (anaphylaxis): rash, swelling, difficulty breathing

Precautions & Warnings

  • Before prescribing Neqlofol, clinicians should consider several safety measures.
  • Assess infection risk: avoid use during active respiratory infections
  • Monitor growth in children: long‑term corticosteroid may affect growth velocity
  • Ensure correct inhaler technique: proper use maximizes benefit and reduces side effects
  • Do not discontinue abruptly: taper under medical supervision after prolonged therapy
  • Store at room temperature: keep inhaler in original packaging, protect from moisture and heat

Avoid Interactions

Neqlofol can interact with other medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • Beta‑blockers: may diminish bronchodilator effect
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase systemic corticosteroid exposure
  • MAO inhibitors: potential cardiovascular interactions

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate hypokalemia
  • Theophylline: may raise plasma concentrations
  • Concurrent inhaled corticosteroids: additive systemic effects

Frequently Asked Questions

Neqlofol is a prescription inhalation product that combines an inhaled corticosteroid with a long‑acting β2‑agonist. It is used for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD), helping to control symptoms, reduce inflammation, and prevent exacerbations when taken regularly as directed by a healthcare professional.

Beclometasone dipropionate binds to glucocorticoid receptors in airway cells, modulating gene transcription to suppress inflammatory mediators such as cytokines, chemokines, and adhesion molecules. This anti‑inflammatory action reduces airway swelling, mucus production, and hyper‑responsiveness, contributing to improved breathing in chronic respiratory conditions.

The dose of Neqlofol is individualized and set by the prescribing clinician based on the severity of the disease, patient age, and response to therapy. Patients should follow the specific instructions on the prescription label and consult their healthcare provider for any adjustments.

Safety data for Neqlofol in pregnancy and lactation are limited. The decision to use it should be made by a qualified healthcare professional after weighing potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss treatment options with their doctor.

To order Neqlofol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Neqlofol combines beclometasone, an inhaled corticosteroid, with formoterol, a long‑acting β2‑agonist, similar to other ICS/LABA products such as budesonide/formoterol. The clinical efficacy is comparable, offering both anti‑inflammatory and bronchodilator effects. Choice among products often depends on device preference, dosing schedule, patient tolerance, and formulary considerations.

Neqlofol should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and excessive heat. Keep the inhaler away from direct sunlight and do not expose it to freezing temperatures. Follow any additional handling instructions provided in the product insert.

Neqlofol is delivered via inhalation using a metered‑dose inhaler or similar device. Patients should prime the inhaler according to the manufacturer’s guidelines, exhale fully, place the mouthpiece in the mouth, and inhale slowly and deeply while actuating the device. A spacer may be recommended for certain patients to improve drug deposition.

Serious risks include paradoxical bronchospasm, which presents as sudden worsening of breathing, and adrenal suppression, which can affect the body’s stress response with prolonged use. Additionally, severe allergic reactions such as anaphylaxis may occur. Patients should seek immediate medical attention if they experience these or any unexpected symptoms.

Neqlofol is contraindicated in individuals with known hypersensitivity to beclometasone, formoterol, or any excipients in the formulation. It should also be avoided in patients who have experienced a severe paradoxical bronchospasm with inhaled corticosteroids or long‑acting β2‑agonists. Clinicians must assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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