Product image of Neqlofol (Beclometasone Dipropionate, Formoterol Fumarate Dihydrate) supplied by GNH India

Neqlofol

Active Ingredient:
Beclometasone Dipropionate, Formoterol Fumarate Dihydrate
Origin:
EU

Neqlofol (Beclometasone Dipropionate, Formoterol Fumarate Dihydrate)

Beclometasone dipropionate, the active ingredient in Neqlofol, is a inhaled corticosteroid/long‑acting β2‑agonist presented as a combination inhalation product for inhalation use. It is indicated for the maintenance treatment of asthma and chronic obstructive pulmonary disease in adults and adolescents.

GNH India supplies Neqlofol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory‑compliant documentation for global distribution.

Manufacturer / TM Owner

Alkaloid-Int D.O.O.

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Indications & Clinical Uses

Neqlofol combines an inhaled corticosteroid with a long‑acting β2‑agonist to provide maintenance therapy for obstructive airway diseases.

  • Asthma: improves symptom control and reduces the frequency of exacerbations.
  • Chronic obstructive pulmonary disease (COPD): maintains lung function, decreases breathlessness and lowers exacerbation risk.
  • Severe asthma (add‑on therapy): used when high‑dose inhaled corticosteroid alone does not achieve adequate control.

How It Works

  • Beclometasone dipropionate binds to glucocorticoid receptors in airway cells, suppressing inflammatory gene expression and reducing cytokine production. Formoterol fumarate dihydrate activates β2‑adrenergic receptors on bronchial smooth muscle, increasing cyclic AMP levels and causing sustained bronchodilation. The combined actions address both inflammation and bronchoconstriction, providing long‑term airway stability.

Side Effects

Neqlofol may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Throat irritation or soreness.
  • Hoarseness of voice.
  • Cough during or after inhalation.
  • Oral candidiasis (thrush).
  • Headache.
  • Tremor.

Serious or Rare Side Effects

  • Paradoxical bronchospasm.
  • Adrenal suppression with systemic effects.
  • Cardiac arrhythmias or significant tachycardia.
  • Severe allergic reactions (anaphylaxis).
  • Pneumonia, especially in COPD patients.

Precautions & Warnings

Before prescribing Neqlofol, clinicians should consider several safety aspects.

  • Assess infection risk: evaluate for active respiratory infections prior to initiation.
  • Monitor growth in children: conduct regular height measurements.
  • Avoid abrupt discontinuation: taper under medical supervision to prevent adrenal insufficiency.
  • Use a spacer device: reduces oropharyngeal deposition and irritation.
  • Monitor cardiovascular status: watch for tachycardia or arrhythmias in susceptible patients.
  • Store below 30°C: keep in original container, protect from moisture and heat.

Avoid Interactions

Neqlofol can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Beta‑blockers: may diminish bronchodilator effect and precipitate bronchospasm.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): increase systemic exposure to beclometasone.
  • Systemic corticosteroids: additive immunosuppression risk.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypokalemia from β2‑agonist activity.
  • Other long‑acting bronchodilators: risk of overlapping pharmacologic effects.
  • Antihistamines or anticholinergics: monitor for additive anticholinergic side effects.

Frequently Asked Questions

Neqlofol is a prescription inhalation product that combines an inhaled corticosteroid with a long‑acting β2‑agonist. It is used for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD) to improve symptom control and reduce the risk of exacerbations.

Beclometasone dipropionate activates glucocorticoid receptors in airway cells, suppressing the production of inflammatory mediators and cytokines. This reduces airway inflammation, edema, and mucus production, helping to keep the airways open and less reactive.

The specific dose and dosing schedule of Neqlofol are determined by the prescribing healthcare professional based on the patient’s age, disease severity, and response to therapy. Patients should follow the prescriber’s instructions and the device’s dosing guide.

Safety data for Neqlofol in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their healthcare provider.

To request Neqlofol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Neqlofol combines beclometasone, a potent inhaled corticosteroid, with formoterol, a fast‑acting long‑acting β2‑agonist. Compared with single‑component inhalers, this combination offers both anti‑inflammatory and bronchodilator effects in one device, potentially improving adherence and providing quicker symptom relief than some other corticosteroid/LABA pairs.

Neqlofol should be stored below 30 °C, in its original packaging, protected from moisture and direct heat. The inhaler should be kept upright, and the mouthpiece should be cleaned regularly according to the manufacturer’s instructions to maintain device performance.

Neqlofol is delivered via a press‑urized metered‑dose inhaler. The patient should exhale fully, place the mouthpiece in the mouth, seal lips around it, and inhale slowly and deeply while actuating the device. A spacer may be used to reduce oropharyngeal deposition, and the patient should rinse the mouth after use.

Serious adverse events include paradoxical bronchospasm, adrenal suppression, significant tachycardia or arrhythmias, severe allergic reactions such as anaphylaxis, and pneumonia in COPD patients. Any sudden worsening of breathing, unexplained fatigue, or signs of infection should prompt immediate medical evaluation.

Neqlofol is contraindicated in patients with a known hypersensitivity to beclometasone, formoterol, or any excipients in the inhaler. It should also be avoided in individuals who have experienced a severe allergic reaction to other inhaled corticosteroids or long‑acting β2‑agonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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