Nerisone Gras (Diflucortolone Valerate)

Diflucortolone Valerate is a potent corticosteroid indicated for a range of inflammatory skin disorders. It works by reducing inflammation, itching and redness in affected areas.

• Eczema: alleviates inflammation and pruritus, promoting skin healing.
• Atopic dermatitis: controls flare‑ups and reduces severe itching.
• Contact dermatitis: diminishes allergic skin reactions and swelling.
• Psoriasis: softens plaques and limits scaling.
• Other inflammatory skin disorders: provides anti‑inflammatory relief where conventional steroids are insufficient.

• Diflucortolone Valerate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses the synthesis of pro‑inflammatory cytokines, prostaglandins, and leukotrienes while enhancing anti‑inflammatory proteins, leading to reduced edema, erythema, and immune cell infiltration in the skin.

Topical corticosteroids can cause local and systemic adverse reactions, varying with potency, duration of use and treated area.

Common Side Effects

• Burning or stinging sensation at the application site
• Itching or mild irritation
• Dryness or flaking of the skin
• Redness or mild erythema
• Folliculitis or acneiform eruptions
• Pruritus worsening after initial use

Serious or Rare Side Effects

• Skin atrophy or thinning
• Hypopigmentation or depigmentation
• Allergic contact dermatitis
• Secondary bacterial, fungal or viral infection
• Systemic corticosteroid effects (e.g., adrenal suppression)
• Delayed wound healing or ulceration

Proper use of Diflucortolone Valerate requires attention to several safety considerations.

• Apply only to affected skin areas: avoid healthy skin and mucous membranes.
• Avoid use on infected or ulcerated skin unless directed by a physician.
• Do not cover with occlusive dressings unless specifically instructed.
• Limit duration of therapy: use the shortest effective period.
• Use with caution in children under two years of age.
• Store at room temperature: keep in the original container, protect from moisture and light.

Diflucortolone Valerate may interact with other agents, altering efficacy or safety.

Major Interactions (Avoid)

• Systemic corticosteroids: increased risk of systemic side effects.
• Antifungal agents (e.g., azoles): potential reduction in antifungal effectiveness.
• Live vaccines: possible immunosuppression compromising vaccine response.

Moderate Interactions (Monitor Closely)

• Topical antibiotics: heightened risk of local irritation.
• Photosensitizing drugs: increased sensitivity to sunlight, advise photoprotection.